Crohn's Disease Analysis

Crohn’s Disease was named after an American gastroenterologist, Dr. Burrill Bernard Crohn, in 1932. He and his colleagues discovered an abnormal pathogen, Mycobacterium paratuberculosis while studying a related disease, ulcerative colitis, which belongs to a larger group if illnesses called Inflammatory Bowel Disease (IBD). The discovery was made while studying the effects of ulcerative colitis in cattle and noticing the similar characteristics in humans. The infections had an abnormal response with the body’s immune system in both the cattle and humans.

While there is no known cause, some people suspect that certain kinds of mycobacterium may really be the cause of Crohn’s disease, but that is just

A problem that affects the daily life of more than a hundred million people is inadequate sanitation and a lack of proper sanitation facilities. For example, only 87% of Indians in urban areas have access to a sanitized latrine, while only 33% of Indians in rural areas have access to a toilet, (The Guardian). This statistic is alarming, as it increases the susceptibility to diseases such as

The innate and adaptive immune response start with exposure to an antigen in the epithelium of

Crohn’s disease may occur at any age but occurs most often between the ages of 15 and 40 years. Crohn’s disease tends to run in some families. About 20 percent of people with Crohn’s disease have a blood relative with an inflammatory bowel disease. Crohn’s disease rates appear to run higher in those that smoke. This means an individual who may inherit an inflammatory bowel disease, is more likely to develop Crohn’s disease if they smoke (Satsangi, 1996, p.40). Both sexes are affected with the women as a slightly higher chance. Crohn’s disease occurs more often in Jewish and upper-middle class urban populations (Lewis et al, 1996, p.1231).

3. Describe the factors that are believed to contribute to the etiology of Crohn’s disease.

Crohn's disease is an inflammatory bowel disease (IBD). It causes inflammation of the lining of your digestive tract, which can lead to abdominal pain, severe diarrhea and even malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people. The inflammation caused by Crohn's disease often spreads deep into the layers of affected bowel tissue. Like ulcerative colitis, another common IBD, Crohn's disease can be both painful and debilitating, and sometimes may lead to life-threatening complications. Although it may involve any part of the digestive tract from the mouth to the anus, it most commonly affects the last part of the small intestine (ileum) and/or the large

Crohn’s disease is a chronic inflammatory bowel disease that causes an inflammation of the GI tract. The symptoms of this disease are mild to severe, and they commonly include varying degrees of abdominal pain, frequent diarrhea, fatigue, rectal bleeding, and unexplained weight loss. Crohn’s disease is a lifelong and progressive condition that leaves approximately seven-hundred thousand Americans without a cure. As disheartening as it is, it has proven my little sister to be the fighter of my family and has lead me to admire her for it. Her battle with her new health condition has shown me how to brave and optimistic in the most trying of situations.

diagnosis doctors will review family history and do a physical examination. Some risk factors include cigarette smoking and some genetic mutations. In children, the use of antibiotics may have an effect leading to Crohn’s Disease. 1 Although CD may occur at any age, it tends to occur before the age of 30. The disease is common among whites and Eastern European Jewish descent. These ethnicities are at higher risk but Crohn’s disease can affect anyone.4

Crohn’s disease is an inflammatory bowel disease that is defined by inflammation of the digestive system. It can affect any part of the GI tract, including the mouth and anus (Abbvie Inc, 2016)). Crohn’s disease does not have a cure and there is no exact cause for the occurring disease. “Since the exact cause of Crohn’s disease is unknown, it has been linked to a combination of environmental factors, immune function and bacterial factors, as well as a patient’s genetic susceptibility to developing the disease” (History Cooperative, 2014).

First of all, Crohn’s disease usually involves the small intestine and it may lead to nutrient malabsorption. One thing that has been figured out by researchers is, genetic and environmental factors definitely contribute to the development of Crohn’s disease. This disease can really occur in any region of the Gastrointestinal Tract (GI Tract) but, for most cases it will affect the ileum, and the large intestine. Patients who suffer from Crohn’s disease will likely develop Lesions in different areas in the intestine, and eventually normal tissue separating the affected areas. Inflammation of the intestine can extend deeply into intestinal tissue and this usually is caused by ulcerations, fistulas, or fissures. Fistulas are normally the main cause out of those three, this is where abnormal passages between the organs or tissues allow the passage of fluids or secretions. With scar tissue resulting from Fistulas, the tissue eventually thickens, and this narrows the lumen and it sometimes causes strictures and/or obstructions. We know that having Crohn’s disease

Perianal Crohn’s disease was identified in 524 patients (30.4%), constituting approximately one-third of the study cohort. When Montreal disease classification was applied; more than half the patients (54.2%) exhibited complicated disease behavior; characterized by

This essay will focus on Crohn’s disease and pathological changes that may occur in the small intestine as a result of the inflammatory process and discuss the scientific reasons for the possible treatments relating these to pathological processes.

I first came across the term “hygiene hypothesis” in a novel titled Parasite, by Mira Grant. It described a future where autoimmune disorders have become endemic, and people are dependent upon helminthic therapy to prime their immune system. That topic sparked an interest in me, and upon searching, I found that autoimmune disorders are much more prevalent in industrialized nations than third world nations, where sanitation is not prioritised as much as developed nations. It seems that our endeavour to wipe out microorganisms is turning upon us and making our immune system attack our own body.

It is possible that people do not wash their hands as often as they should. Handwashing prevents both diarrhoea and respiratory infections effectively whendone properly and at