Crohn's Disease Research Paper

Complications of Crohn’s may include bowel obstructions, ulcers, fistulas, malnutrition, anal fissures, colon cancer and other health problems. The bowel may become thickened and narrowed disallowing digestive contents to exit

Crohn’s disease is a chronic condition that affects a person’s digestive system with no known cause. When Crohn’s disease strikes, it can affect any part of your digestive system ranging from your mouth, all the way to your anus. Crohn’s disease is chronic and there is no known cure for this condition. So basically, once someone is diagnosed with this condition, they might as well get used to living out the remainder of their life being affected by Crohn’s disease. Crohn’s is not, shall we say, “constant”. The symptoms happen on and off in what are usually called “flare-ups”.

Crohn 's disease is one of two conditions referred to by the term "Inflammatory Bowel Disease" (IBD). The other condition that is referred to as an IBD is called Ulcerative Colitis. Both Crohn’s and Ulcerative Colitis are conditions that cause recurring or persistent inflammation in one or more sections of the intestine. The literal definition of "inflammation" is "being set on fire". It is a protective reaction that happens when tissue is injured or destroyed. There are two types of inflammations. The first is acute inflammation, which is defined by heat, redness, pain and swelling. The

especially in the colon. This drug can be used for as long as needed, and it

Crohn’s disease is characterized by inflammation of segments of the GI tract. The parts of the tract where Crohn’s disease is most often seen are in the terminal ileum, jejunum, and right side of colon. Involvement of the esophagus, stomach, and duodenum is

Crohn's disease is an inflammatory bowel disease (IBD). It causes inflammation of the lining of your digestive tract, which can lead to abdominal pain, severe diarrhea and even malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people. The inflammation caused by Crohn's disease often spreads deep into the layers of affected bowel tissue. Like ulcerative colitis, another common IBD, Crohn's disease can be both painful and debilitating, and sometimes may lead to life-threatening complications. Although it may involve any part of the digestive tract from the mouth to the anus, it most commonly affects the last part of the small intestine (ileum) and/or the large

Crohn’s disease is a debilitating disease that can affect your entire life and lifestyle if you allow it to. It affects someone that is very dear to me, my best friend’s mother, Stephanie. I see her live through this day in and day out, and it has raised many questions in my mind. Questions like how you get it, why you get it, and what you really go through when you have it. It is something I have little knowledge of, and by learning more information on it, I feel as if I can possibly help her cope with it in the future.

“I will keep fighting,” is what I remind myself as soon as the sun peaks up. Many people are not aware of Crohn’s, nor did I when I was diagnosed at age 8. I have learned Crohn’s is not just a simple disease; it changes lives. My experiences with Crohn’s built me into a stronger person, both physically and mentally. Crohn’s caused me to grow up rapidly, faster than my fellow classmates. Entering high school with Crohn’s had been a remarkably frightening experience, yet at the end of each day, I decided I was not going to allow my disease to define who I am. So when you walk through those high school doors, remember: be who you are, not what Crohn’s makes you. Participate in activities you loved to do before you got Crohns- just modify them.

Crohn’s disease was first discovered in 1932 by three doctors named Burrill Crohn, Leon Ginzberg, and Gordon D. Oppenheimer. The Crohn’s & Colitis Foundation of America (2014) declared “these doctors collected data from 14 patients with symptoms of abdominal cramps, diarrhea, fever, and weight loss, which showed that the symptoms were not the result of tuberculosis or any other known disease. They described a new disease entity, which was first called regional ileitis, and later, Crohn’s disease” (p. 7). Even though Crohn’s Disease was discovered over 80 years ago, there is no cure, but there is constantly more new information being found out about this disease.

Crohn’s disease is a chronic inflammatory bowel disease that is characterized by inflammation of the digestive, or gastrointestinal tract. It can affect any part of the GI tract, including the mouth and anus. However, Crohn’s most often affects the end of the small intestine (Crohn’s & Colitis, 2016). Crohn’s disease does not have a cure and there is no exact cause for the occurring disease. “Since the exact cause of Crohn’s disease is unknown, it has been linked to a combination of environmental factors, immune function and bacterial factors, as well as a patient’s genetic susceptibility to developing the disease” (History Cooperative, 2014).

Crohn’s disease is a chronic inflammatory disease that was once considered as rare in the pediatric population, is presently recognized as one of the most important chronic diseases that affect children and adolescents. About twenty to thirty percent of patients diagnose with Crohn’s disease before the age of twenty years. Crohn’s disease can cause growth failure, malnutrition, pubertal delay and bone demineralization in children. The incidence of Crohn’s disease has increased over the past decades. The age specific rate in North America for children age ten to nineteen years estimated as about 3.5 cases per 100, 000 population. The study of pediatric Crohn’s disease form North America showed the rate of Crohn disease in Wisconsin was 4.56 cases per 100,000 population. The rate of pediatric Inflammatory Bowel Disease (IBD) was higher in boys than in girls. Crohn’s disease is more common in whites than in blacks and is rare in Asian and

Crohn’s disease is a type chronic inflammatory bowel disease of the gastrointestinal tract affecting 26-200 per 100,000 in European Populations. 10 There is currently no known cure and disease is managed by a combination of immune- suppressing medications, nutritional changes or surgery. 4 Most commonly, the disease affects the ileum and colon but complications can be present in any part of the gastrointestinal tract. Disease symptoms are persistent diarrhea, abdominal pain and cramping, loss of weight, and fever. 13 Most patients have chronic bleeding from inflamed tissues in the gastrointestinal tract. This can lead to anemia. In some cases, problems affecting joints, eyes, and skin may occur. 13 In some patients, fistulae can occur. Fistulae

Patients suffering from Crohn’s disease have a risk of developing obstruction, fistulae, abscess formation, and chronic blood loss (McCance, Huether, Brashers, & Rote, 2014).  These patients are also at greater risk for developing intestinal carcinoma. In our case study, our patient shows classical manifestations of a small bowel obstruction.  Obstruction in Crohn’s disease can occur due to chronic inflammation and remodeling of the mucosal lining, leading to the formation of scar tissue. Obstruction of the small bowel will lead to abdominal distention, vomiting of bilious material, and increase temperature. These symptoms are present in our patient.  If medications are unsuccessful at relieving the patient’s symptoms, surgery may be necessary.

It is possible to say that the Vienna Classification model and its recent amendments proposed in Montreal are internationally accepted as the most comprehensive framework of classifying Crohn’s disease. Basically, the model singles out three key behavioral phenotypes of disease development, focusing on different variants of progression such as inflammation, obstructing and penetrating (Laass, Roggenbuck, & Conrad, 2014). It is also vital to say that this classification is detailed enough to provide disease’ categories by location of inflammatory process, severity of disorder and age of patients, what brings structural integrity to clinical examination and diagnosis of the disease. The age of a patient is considered in the context

Probiotics and prebiotics are useful in inducing and maintaining remission in ulcerative colitis, pouchitis and Crohn’s disease. Improvement in ulcerative colitis and pouchitis has been seen in probiotics VSL#3 and E. coli Nissle 1917 and prebiotics FOS/Inulin combination therapy. Probiotics play less of a role in Crohn’s disease, however some studies have proven clinical benefit of VSL#3 and E. coli Nissle 1917 as well. Prebiotics that show improvement of Crohn’s disease include FOS/Inulin therapy and lactulose in limited studies over the last decade. Future use of alternative therapies such as probiotics and prebiotics can lead to the reduction and replacement of pharmaceutical therapies and even surgery. Dietary therapies