Current Mechanism And Concepts Of Pathogenesis Of Atherosclerosis

1890 Words Nov 14th, 2014 8 Pages
Current mechanism and concepts in pathogenesis of Atherosclerosis

Introduction
Atherosclerosis is classified as a chronic, progressive, and multifactorial disease of moderate and large sized arteries categorised by intimal lesions called atheroma plaques that pushes into the vessel lumens. Atherosclerosis leading to coronary artery is the main cause of coronary artery disease (CAD). It is vital to appreciate the central mechanisms of atherogenesis in order to understand the adverse clinical results of Coronary Artery Disease and their ensuing management. The progression of atheroma consist of several cellular and molecular events with endothelial dysfunction, leucocyte recruitment and dispedesis, LDL transcytosis, LDL oxidation, recruitment and proliferation of smooth muscle cells, synthesis of extracellular matrix proteins, build-up of foamy macrophages as well as interplay of different cytokines. (Bisht et al, 2012).

Atherosclerosis known as the leading cause of death globally - has established much attention as to its origins, mechanisms, treatment, and distinct patterns in particular populations (Hansson et al, 2011). In the late 19th to early 20th century, atherosclerosis was recognized as a degenerative illness in the elderly, and not a disease which decreases length and quality of life (Mayerl et al, 2006 and McMillan, 1995).

Figure.1 shows the start, development, and difficulty of human coronary atherosclerotic plaque. The top shows longitudinal section of…
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