Cushings Syndrome Essay

816 WordsOct 10, 20124 Pages
Cushing’s Syndrome Cushing’s Syndrome is a condition that results from chronic exposure to excessive amounts of glucocorticoids circulating in the blood stream for an extended period of time. The disease was first reported by Harvey Cushing over one hundred years ago, yet the condition still plagues endocrinologists today. Reasons for this difficulty include the vast amount of often vague symptoms that the syndrome presents, most of which are found in a plethora of other conditions as well, combined with the multiple forms that the condition can manifest itself. Symptoms of Cushings Syndrome include, but are not limited to, weight gain, hirutism, easy bruising, hypertension, acne, facial plethora, muscle weakness, striae, depression,…show more content…
With Cushings syndrome, this cycle is disrupted, resulting in an excess of circulating cortisol. There are multiple mechanisms that can disrupt the cycle and they can be classified as either ACTH-dependent or ACTH-independent Cushings Syndrome. The most common form of Cushings Syndome is an ACTH-dependent form called Cushings Disease. This type accounts for two thirds of cushings syndrome and is the result of either an adenoma or carcinoma on the pituitary gland. The tumor causes overproduction of ACTH, resulting in increased release of cortisol from the adrenal gland. ACTH- dependent Cushings Syndrome can also result from ectopic tumors that cause overproduction of ACTH or CRH. The most frequent is small-cell lung carcinoma (12% of patients develop Cushings syndrome). A final type of ACTH dependent cushings syndrome is from exogenous ACTH administration, typically the use of synthetic steroids. ACTH-independent Cushings Syndrome typically originates from abnormalities of the adrenal gland. Adrenal adenoma and adrenal carcinoma occur when there is a benign or cancerous tumor on the adrenal gland. These tumors can cause over production of cortisol, disrupting homeostasis. Other diseases like Carney complex and McCune Albright syndrome have also been associated with abnormalities of the adrenal gland, causing overproduction of cortisol. A final form of cushings syndrome is exogenous glucocorticoid administration. The treatment of Cushings
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