Cystic Fibrosis: Dr. Dorothy Hansine Anderson

Cystic Fibrosis is a life threatening condition that causes severe damage to the lungs and digestive system. Developing this condition can change a person's entire life. Depending on the severity of the condition a person can be affected by mild symptoms such as shortness of breath, all the way to severe symptoms such as rectal prolapse, or even death. Screening is done on infants in all 50 states; therefore if a child has inherited Cystic Fibrosis it will be known in the first months of life. As professional staff members of a nursing community it will be necessary to help prepare the child and the family for the life of Cystic Fibrosis.

Many years ago people were diagnosed with Cystic Fibrosis but there was no cure. Children were dying from this disease at very young ages. The Cystic Fibrosis Foundation was then formed in 1955 by mothers who were determined to find a cure for their dying children. There is still no cure but there are treatments that help with the infections that grow in the lungs of people with CF. There are people still researching for a way to cure Cystic Fibrosis, but what is the Cystic Fibrosis Foundation all about?

Cystic fibrosis is a terrible disease that affects everyday life for most people. There is no cure for the disease but we will never lose hope for one. Technology and medicines have advanced well over time. Living with cystic fibrosis is a hard life and it takes a strong individual to fight for their life. My sister was one of the strong individuals who fought for her life. Emily was born on August 23, 2012 and lost her life on November 2, 2012. She was strong princess and a warrior whom’s time on earth was very limited. She is a fine example of what it takes to be a fighter! [thesis] What is cystic fibrosis, how it affects their lives, and how it impacts the others around them.

Five year old Ellis Miles undergoes numerous treatments each day to counteract the symptoms that accompany cystic fibrosis including physiotherapy, pills containing digestive enzymes, and a treatment which breaks up the mucus in her lungs. Cystic Fibrosis has numerous life threatening symptoms and while there is no cure, there are several treatments that a typical patient undergoes each day to combat these symptoms. The most prominent symptom associated with Cystic Fibrosis is a thick mucus that clogs up tubes that carry out crucial roles in the human body. This mucus especially affects the respiratory tract. Mucus builds up in the respiratory tract making it difficult for individuals with cystic fibrosis to have a frequent cough that produces a thick

Cystic Fibrosis an inherited genetic disorder. This disorder is present when a child has 2 abnormal copies of the CFTR gene. There is a defect or a mutation in this gene that changes the protein which regulates the movement of salt in and out of cells. A mutation or defect is an alteration. This means that there is a change in the CFTR gene which causes it to perform improperly.

Cystic fibrosis is the most common lethal inherited disease, affecting about 30,000 patients worldwide. In the past decade, strides in patient management and the development of new pharmacological agents, coupled with scientific and technological advances, have increased the mean life expectancy of CF patients to approximately 30 years of age (approximately 50% of CF patients live to the age of 30). As early as 30 years ago, the median survival age was 8 years. Chronic lung infections, which lead to declines in lung function, remain the major cause of morbidity and mortality. While several pathogens have been implicated, Pseudomonas aeruginosa—an opportunistic and virulent bacterium—has an affinity for the

Cystic Fibrosis cannot be developed or contracted it is something you’re born with. CF is a recessive disease, it occurs when a child inherits one defective copy of the gene from each parent. This gene mutation is responsible for cystic fibrosis. ("Cystic fibrosis Canada," 2011) This gene is known as the CFTR gene ("www.medincinet.com," 1996). Reference Figure 3. The “gene makes a protein that controls the movement of salt and water in and out of your body's cells. In people who have cystic fibrosis, the gene makes a protein that doesn't work right. This causes the thick, sticky mucus” ("www.medincinet.com," 1996).

The type of mutation that causes Cystic Fibrosis occurs in the CFTR gene, or Cystic Fibrosis Transmembrane Conductance Regulator gene. This gene is important to the body because it helps provide channels that transport negatively charged particles (chloride ions) in and out of the cell. Chloride has an important role in the human body by how it controls the movement of water in tissue, which allows mucus to become thin. Mutations in the CFTR gene interrupts the function of the chloride channels. It makes the regulating process of the flow of chloride ions and water across the cell membranes not happen. This causes passageways to produce mucus that is very thick. The thick mucus causes these passageways to clog, and trap

​Cystic fibrosis is a disease that is continually affecting children and adults in the United States. This is an inherited and life-threatening disease which affects many organs in the body. According to the Center for Disease Control, there are an estimated 30,000 people affected by this disease today. There are also approximately 2,500 babies born each year with Cystic fibrosis and unfortunately there are millions of people unaware they even carry the gene for this disease.

Cystic Fibrosis is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) which is located in the middle of chromosome 7. The CFTR gene encodes a protein of the same name. This protein functions as a “channel across the membrane of cells that produce mucus, sweat, saliva, tears and digestive enzymes” (Genetics Home Reference, 2015). The channel transports chloride ions which are negatively charged particles, in and out of cells which help in controlling the water movement in tissues to allow for the production of thin, feely flowing mucus, a substance that lubricates and lines the airways, digestive system, reproductive system and other tissues and

Cystic Fibrosis (Mucoviscidosis) is a disease that changes how the body produces sweat, and mucus glands. It causes organs such as the lungs to not function properly, and could be life threatening. Cystic Fibrosis is a genetic disease, and affects around 70,000 people worldwide. Every year a thousand new cases are reported.

In 1985 the gene causing cystic fibrosis was narrowed down to chromosome 7. This discovery paved the way for Professor Lap-Chi Tsui, Dr Francis Collins and Professor Jack Riordan to identify the specific faulty gene responsible for cystic fibrosis, in 1985. The team 's discovery of what they called the cystic fibrosis transmembrane conductance regulator (CFTR) is the single most important discovery in cystic fibrosis research to date.

Maria has Cystic fibrosis, based on her symptoms. Cystic fibrosis is a genetic disorder, it is carried on chromosome number 7.  It requires two copies, one from each parent, to show the symptoms of Cystic fibrosis. It produces a defective form of a protein (CFTR). It affects the lungs and the digestive system. The function of the epithelial cells, found in sweat glands in skin and line the lungs, liver, pancreas, digestive, and reproductive system, are disrupted. When the disorder is present, the way chloride passes over the cell membrane cannot regulate. It messes up the salt and water needed to maintain the coating of fluid in the lungs, and other organs. When the salt and water lining becomes too thick, it does not function properly. For

Cystic Fibrosis is a recessive disorder that is a life threatening disease that causes persistent lung infections and progressively limits the ability to breath. Unfortunately, there is no cure for this genetic disorder, but Airway Clearance, Inhaled Medicines, and Pancreatic enzyme supplements can increase the person’s lifespan incredibly. There are about 70,000 people worldwide with this disease. Approximately 1,000 new cases of cystic fibrosis are diagnosed each year. The average human with cystic fibrosis lives to about 30 if they take their medicine.

Cystic Fibrosis is caused by a genetic defect in Chromosome 7. Chromosome 7 encodes the cystic fibrosis transmembrane conductance regulator, also known as CFTR. There are over 1,000 mutations of this gene causing cystic fibrosis, with each mutation manifesting as a different variation of disease onset and clinical presentation. The most common mutation is the loss of phenylalanine residue at deltaF508. The abnormal functioning CFTR causes impaired chloride transport and more viscous secretions. The defect causes dehydrated secretions in the respiratory tract and gastrointestinal tract. Being dehydrated, these secretions become more difficult to move throughout the body. Along with impaired