Cystic Fibrosis Research Paper

CF is broken into 6 classes of the disease. Class 1 through 3 appears to be more severe than the latter 4 through 6; which mainly result in only pancreatic deficiency. The rate of deaths due to cystic fibrosis is dependent on the class of disease and age of diagnosis which can range from 6 months old to 10 years old. The average age of survival, with treatment, in the United States is 25 years old. Abnormal secretions cause respiratory, digestive and reproductive obstructions. Respiratory failure is caused by mucous impaction of airways due to plugging, chronic inflammation and infection. Respiratory infections are the main cause of death. A person with cystic fibrosis has a persistent cough or wheeze resulting in some sputum production and reoccurring pneumonia. This excess mucus creates a chronic bronchiectasis within the lungs resulting in cyst and peripheral bullae formation. (McCance et al., 2010) Excessive coughing called coughing fits normally allow a person to clear their airways and remove the excess fluid from their lungs. However, in CF when a person has a coughing fit they produce very little mucus excretion and do not have any symptom relief. This could cause a rupture of one of the many peripheral bullae leading to pneumothorax, a collapsed lung. (McCance et al.,

Cystic fibrosis is a autosomal recessive inherited disease that affects many organ systems. Over time the outcome for patients with the disease has improved drastically. The life expectancy for patients has increased to 37 years old, compared to 31 years old (O’ Sullivan, 2009). Researchers have reviewed the etiology, pathogenesis and clinical manifestations for cystic fibrosis.

Kids who acquire a broken CFTR quality from every guardian will have CF. Youngsters who acquire one flawed CFTR quality and one typical CFTR quality are "CF bearers." CF transporters generally have no indications of CF and live ordinary lives. Be that as it may, they can pass the flawed CFTR quality to their youngsters. The indications aren't the same for everybody. Be that as it may, some normal manifestations in an infant who has cystic fibrosis. A blocked small digestive tract during childbirth. This keeps the infant from passing his or her first stool. Very salty sweat or skin, diarrhea, not developing or putting on weight the way that other kids do, breathing issues, lung contaminations, a hack that does not go away, and wheezing are signs of CF. Different side effects might likewise create in youth, for example: Clubbing of the fingers, rectal prolapse and growths in the nose or

Cystic fibroses (CF) is a genetically inherited disease that is caused by a recessive allele and has to be inherited from both parents. The gene can lie dormant in both parents and they can live perfectly healthy lives however as they carry the gene it means there is a risk of it being passed onto the child. One in 25 of us carries the faulty gene that causes it (CF trust , n.d.) not many people are aware that they even carry the gene as it is only able to affect an individual if they have 2 recessive alleles of the gene. The defective gene affects the body’s ability to transfer water and salt to and from cells that produce sweat, mucus, and digestive enzymes (Alma, 2016) this means CF suffers produce a very thick sticky mucus that covers the

Cystic fibrosis is a disease in which mucus blocks the airways in the lungs. This causes lung infections over time and limits patients to breathe for a significant amount time. As the infections progress, this can eventually lead to respiratory failure. The mucus stop the pancreas from releasing digestive enzymes and prevents the body from breaking down nutrients. As this is a genetic disease, patients usually inherit two genes of cystic fibrosis. Carriers with one copy of cystic fibrosis do not inherit the disease. Patients that have CF has an abundant amount of bacteria within the lungs. The mucus can affect much more than the lungs and pancreas. For example, mucus can wedge the bile duct and cause liver disease. Even with men diagnosed

Cystic fibrosis is a hereditary condition which “affects the cells that produce mucus, sweat, and digestive juices.” In cases of cystic fibrosis a defective gene causes these fluids to become thick instead of thin. These fluids lose their lubricating properties and can interrupt normal functions, especially in the lungs. The thick mucus can also cause digestive problems by blocking the essential digestive enzymes entering the small intestine from the pancreas (Mayo Clinic). It is inherited through “an autosomal recessive pattern”. Essentially meaning that both parents are carriers for the disease, but are unlikely to show symptoms themselves (GHR).

The airways of patients with cystic fibrosis are eventually obstructed by mucus and hyper-inflated; lung function becomes progressively worse as the airway walls are repeatedly damaged in a cycle of inflammation and infection (Cohen and Prince, 2012). For approximately 90% of patients, respiratory failure will eventually become fatal unless they receive a lung transplant (Davies, Ebdon, and Orchard, 2014). Common symptoms of cystic fibrosis are coughing, diarrhoea, and malnutrition (Haack, Arago, and Novaes, 2013). Patients often experience tachypneoa, wheezing, chronic rhinitis (inflammation of the nose), nasal polyps, haemoptysis (coughing blood) and problems associated with lung inflation such as atelectasis, hyperinflation, or pneumothorax (Lumbamba et Al., 2012). Cystic fibrosis sufferers may also have a barrel chest, club fingers and toes, pulmonary hypertension and low tolerance for physical exercise due to their damaged respiratory system (Lumbamba et Al., 2012). The lack of normal CFTR creates hyper viscous secretions with

Cystic Fibrosis (CF) is a disease that causes problems within the lungs and digestive systems (pancreas, livers, and intestines). It occurs due to the abnormal transport of chloride and sodium across an epithelium, leading to excessive secretion of thick mucus in these two major areas of the body. This makes breathing difficult as the thick, sticky mucus clogs the airway, and it can also result in sinus infections, poor growth, infertility, and reduced life expectancy. However, these can sometimes be treated with antibiotics and other medication, like medicated inhalers.’ It is an autosomal recessive genetic disorder and is caused by one of many different mutations in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR)’ . Because CF is a genetic disorder it is able to be inherited therefore can undergo human manipulations such as Selective Breeding and Gene Therapy.

Cystic fibrosis, a genetic disease that limits one’s ability to breathe, affects mostly the lungs but also can have a damaging effect on the intestine, kidneys, liver, and pancreas. The name cystic fibrosis comes from the characteristic fibrosis and cysts that form within the pancreas. It is a life-threatening illness, which afflicts around 30,000 people in the United States and about 70,000 worldwide, with approximately 1,000 new cases being diagnosed each year and more than 75 percent of those people being diagnosed by the age of two. Nearly half of the cystic fibrosis population is over 18 years of age, and the life expectancy is between 37 to 50 years old. The ailment, commonly referred to as CF, is a recessive disease, so both

Cystic fibrosis (CF) is an autosomal recessive disease that affects the cystic fibrosis trans membrane conductance regulator (CFTR) gene located on Chromosome 7, in a persons DNA. Autosomal means that the gene for CF is not carried on the sex chromosomes and both male and females are affected by the mutation. The disease is a recessive disease meaning that it requires 2 abnormal genes to be expressed; only one gene would mean that the person is a carrier of the disease. This is because the normal CFTR gene dominated the abnormal CFTR gene. For the disease to be present and show in the person, they must have inherited 2 abnormal CFTR genes, one from each parent. Being a ‘carrier’ does not mean that you have CF but it does mean that you can pass the defective CFTR genes onto your children, possibly leading the off-spring being affected by the CFTR genes. It is the most common fatal genetic disease in the US today with an average life span of 25-30 years. (Ndsu.edu, Cystic Fibrosis and Gene Therapy Ndsu.edu,. (2014). Cystic Fibrosis and Gene Therapy. Retrieved 14 August 2014, from http://www.ndsu.edu/pubweb/~mcclean/plsc431/st). CF is a genetic disorder that affects the digestive and respiratry systems. The CFTR gene causes a protein to not work properly blocking the movement of NaCl (Sodium Chloride) in and out of the cell, causing an abnormally sticky and thick mucus to be produced on the out side of the cells. This mucus clogs the lungs leading to infection. It also blocks

This paper is over cystic fibrosis (CF). This is the most common life threatening condition in the white population. In the United States there are about 30,000 people who are living with CF and there are approximately 1,000 new cases diagnosed each year. Nearly half of the CF population is 18 years or older and with new breakthroughs in treatments people with CF are able to live longer lives, with the median age now being 40 years old. CF was first described in the 1930s as a distinct clinical entity, however as early as 1650 there has been several references to infants and children with meconium ileus and characteristics of pancreatic and lung disease. Over the years there are have been many improvements in treatments, but people with CF are not always compliant with their therapies. Mostly because they tend to time consuming. In this paper we will discuss what CF is, the diagnosis, treatment options, and prognosis.

Cystic Fibrosis (CF) is a genetic disorder involving many organ systems of the body but mainly the respiratory system and endocrine system that is often present at birth. What once used to be a detrimental disease, early detection has enabled early treatment resulting in an increase in life expectancy and higher quality of life. Nurses play a crucial role in educating new parents on the impact of the disease and lifestyle changes to ensure the best quality of life for their children.

Cystic Fibrosis (CF) is a disease that causes problems within the lungs and digestive systems (pancreas, liver, and intestines). It occurs due to the abnormal transport of chloride and sodium across cells leading to excessive secretion of thick mucus in these two major areas of the body. This makes breathing difficult as the thick, sticky mucus clogs the airway, and it can also result in sinus infections, poor growth, infertility, and reduced life expectancy. However, these can sometimes be treated with antibiotics and other medication, like medicated inhalers. It is an autosomal recessive genetic disorder and is caused by one of many different mutations in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR)’ . Because CF is the result of an inherited genetic mutation it can therefore be treated with manipulations such as Selective Breeding and Gene Therapy.

Like placing one’s hand on a heated burner, numbing the pain does not solve the issue. In 1980, the average life expectancy for a CF patient was less than 20 years. (New) Recently, scientists realized that in order to treat this complicated disease they would have to investigate a more complex cellular level.

Cystic fibrosis is found most commonly in individuals with European descent and very uncommon in African and Asian descent (O’Sullivan & Freedman, 2009). When cystic fibrosis was first documented in 1938, the life expectancy was only a few months for the patients (O’Sullivan & Freedman, 2009). Cystic fibrosis is still currently an incurable disease; however treatments have greatly improved over the past few decades. Years ago, individuals with cystic fibrosis would rarely live beyond his or her childhood, but now many individuals with the disease are living well into their adulthood (Falvo, 2014). The life expectancy over the past decade has increased tremendously. It