Cystitis Model

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Animal models of the lower urinary tract inflammation varied, including spontaneous cystitis, neurogenic cystitis, autoimmune cystitis, chemical induced cystitis and so on. As one of the most reliable industry leaders, Creative Biolabs is capable of providing both chronic and acute CYP-induced cystitis model occur in rats(SD rats or Wistar rats) and mice. Particularly, Creative Biolabs offers studies of cystitis and inflammatory pathways, including in vivo models as well as complementary in vitro and ex vivo work.

What is chemical induced cystitis?
Inflammation of the lower urinary tract is a relatively common type of inflammation that occurs frequently in people while the casues remain unclear. Animal models of lower urinary tract inflammation have proven to be useful for investigators to study the underlying mechanisms and options for supressing relevant symptoms. Cystitis model induced by intravesical instillation of chemical irritants, including cyclophosphamide and acrolein, is one of the most commonly used experimental model to explore mechanisms underlying pain
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CYP-induced cystitis model displays a local inflammation, associated with an increase in voiding frequency and a decrease in urine volume per void. Consequently, the CYP-induced cystitis model is widely used in rats and mice to characterize new inflammatory and nociceptive pathways, and identify new mediators. Conventionally, the chemical cystitis group was induced by a single intraperitoneal (i.p.) injection of CYP endotoxin, which is a antineoplastic agent that ultimately results in the formation of acrolein in the liver of patients treated with this drug, thus damaging the bladder urothelium and causing hemorrhagic cystitis as well as some other complications. Moreover, Creative Biolabs offers preclinical assessment services, which typically include, but not limited
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