DNA And Huntington's Disease

Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease.

Huntington’s Disease is a genetic disorder characterized by the arrival of symptoms late in life, usually in the 30s or 40s. It is an autosomal dominant disorder, which includes nerve cells breaking down in the brain. There are both movement and cognitive symptoms related to this disease. Some movement symptoms are unintentional jolting, delayed eye movements, and a compromised manner of walking. Some cognitive symptoms are trouble organizing responsibilities, a deficiency of cognizance of one’s own actions and capabilities, and a difficulty in understanding fresh material. There are also psychiatric disorders associated with Huntington’s disease: depression, obsessive compulsion disorder, and mania. Huntington’s disease results from a mutation

family, and an analysis will be done. This sampling of the blood will be performed

Samples of blood, hair skin, or other tissue can be tested. At the laboratory, technicians look at the DNA of the sample. The gene that would be scrutinized would be the IT15 gene, also known as the HTT gene. Though no genetic test is a hundred percent accurate, the test for Huntington's is highly reliable. The genetics test for Huntington’s is convenient, and provides no significant impediment.

Huntington’s disease is a hereditary brain disorder that affects people all over the world. If your parent has this disease, there is a fifty-percent chance that you will develop it at some point in your life. Huntington’s disease is caused by a defect in the dominate gene called huntingtin. This defect is caused by a part of DNA called CAG repeat. Normally the huntingtin gene is repeated about ten to twenty-eight times, and plays a major role in brain development. When a person has Huntington’s disease the huntingtin disease repeats anywhere from 36 to 120 times. When the gene repeats this much the elongated proteins separate into smaller pieces and collect neutrons, disrupting the normal cell function. This effects the parts of the brain

An estimated three to seven out of every hundred thousand people of European ancestry are affected by Huntington Disease. People of Japanese, Chinese, and Asian descendant populations appear to have a less common rate of Huntington Disease(1).

Genetic diseases are conditions caused by abnormalities in the genetic material contained within our cells.

Human beings have two copies of genes that provide genetic information to produce Huntington, which is a protein. The two copies are usually labeled HTT (Hayes & Reichsman, 2009). A portion of this gene is as a result of a repetitive section referred to as a trinucleotide repeat that changes in terms of length from one person to the other, as well as between different generations. In case the repeat section of the gene is present in a gene that is considered healthy, then an active mutation might lead to an increment in the repeat sections, which might in turn lead to a gene that is defective (Marks & Neill, 2007). Subsequently, the length of the repeat portion might reach a given level where it leads to the production of altered and defective proteins

Huntington disease is created by a hereditary deficiency which has 67 exons and is in chromosome 4 which is a human karyotyre and a dominant autosomal chromosome, this means both males and females could be affected by this disorder . The deformity causes a piece of DNA to repeat CAG or

Huntington disease is an inherited disease that affects the brain which results in affected individuals to pass away before the age of 50. As of today, there is no cure. Genetic testing is used to identify genes associated with various inherited diseases. Many people argue that they wouldn’t get tested due to financial issues, stress, or discrimination, but after discussing ethics in genetic testing, I strongly believe that it is best to get tested.

Huntington’s chorea, or more commonly known as Huntington’s disease (HD), is a neurodegenerative disorder that affects both men and women. Although previously thought to be a relatively rare disease, new research discoveries show that it’s actually more common than not; while the onset of symptoms typically occurs in a person’s 40s and 50s, research has also shown that individuals in their 70s, 80s and even 90s have enough repeats in the HTT gene to develop mild HD symptoms. (Samson, 2016) Through the selective degeneration of neurons and with the loss of neurons from the striatum and cerebral cortex, Huntington’s disease affects the nervous system by impacting movement, cognitive abilities, as well as neuropsychiatric symptoms. Unfortunately

Approximately three to four percent of babies born every year are born with some kind of genetic disorder. A genetic disorder is described as an illness caused by an error in one’s genome, and is usually hereditary. To understand how these errors occur, one must first understand the basic concept of genes. Genes are the basic units of heredity and are made up of pieces of DNA that instruct the cell how to make specific proteins. Humans are estimated to have about 20,000 to 30,000 genes in their genome. Chromosomes contain these genes and DNA. Humans have 23 pairs of chromosomes or a total of 46 chromosomes. One pair of these chromosomes determines the sex of a person while the other 22 are autosomal, meaning that they determine the rest of

Huntington's disease is a neurodegenerative hereditary condition which causes problems in muscle coordination, behavioral symptoms and leads mental deterioration (Hammond and Tatum 2010). Symptom varies among persons of same family. The most punctual side effects are frequently unpretentious issues with state of mind or insight.

Huntington’s disease is caused by genetic mutation. The mutation occurs on the HTT gene; the HTT gene contains the DNA used to code for a protein called Huntingtin. The HTT gene is located on the shorter arm of the 4th chromosome. The protein, Huntingtin, is primarily used in neurons in the brain and is also found throughout the body.

The Huntington disease is a type of disease people suffer when they gradually got older, around 30 to 40 years old. It provides instructions for making proteins. The function is unknown, although it plays an important role in the nerves cells, in the brain. HTT mutation causes the Huntington disease and involves a DNA segment known as a CAG trinucleotide. Unfortunately there is no cure for the disease but drugs, physiotherapy and talk therapy can help manage some symptoms.