DRESS Syndrome Research Paper

Causes of hypersensitivity are unclear, but are possibly attributed to paclitaxel itself (via a non-IgE mechanism) or its excipient Cremophor EL via potential complement activation2. Premedication with dexamethasone, diphenhydramine, and a histamine h2 antagonist can reduce the incidence of such hypersensitivity reactions, but they are not entirely preventative. Boulanger et al3 reported the overall incidence of hypersensitivity reactions varied between 8-45%, where minor reactions occurred in 40% of patients and severe reactions occurred in 1.3% of patients. Such reactions predominantly occurred within the first minutes of infusion and mostly during the first or second infusion. In this study3, hypersensitivity reaction grades were determined utilizing the U.S. National Cancer Institute Grading System. In response to a hypersensitivity reaction, medications such as antihistamines, corticosteroids, epinephrine, bronchodilators, or oxygen can be used to alleviate symptoms3. After resolution of symptoms, paclitaxel can be

The Dressmaker (2015), directed by Jocelyn Moorhouse, explores Myrtle ‘Tilly’ Dunnage’s dramatic return to her small hometown of Dungatar, a ‘dump’ located in the middle of nowhere in the Australian outback. Sent away from the town as a child after being held responsible for a murder, Tilly has returned to seek resolution of her murky memories and to take revenge on those who mistreated her. Now a talented dressmaker, Tilly uses her skills to manipulate the townspeople into revealing the intricate secrets that led to her exile. Throughout the film, powerful symbolism present in fire, mirrors and clothing signifies Tilly’s resolution from past issues.

Adverse reactions to drugs are common and almost any drug can cause an adverse reaction.

You don 't come cross anaphylactic shock often, but you still have to be aware. Other severe adverse reactions that could include a fever and skin blistering; these usually occur within an hour of the medications being administered. Sometimes adverse reactions can develop over a few weeks, they may cause damage to the kidneys or liver. If adverse reactions are not treated they could be fatal. When individuals experience adverse reactions to medicines my workplace policy is to inform the GP and explaining in detail the adverse reactions, the staff member will then inform the individual/ team. GP advise and guidance will then determine if the medication is to be stopped. If the reactions are so serious then an ambulance should be called my responsibility is that I have duty to continue to observe the individual and monitor their vitals, speaking to them and looking at any changes, so as to ensure that the individual is not deteriorating. All adverse reactions and following advice given, must be recorded in full in the individual’s clinical note and referenced in their daily report also MAR’s chart. 4.

Rashes:- Rashes can be a side effect of taking medication if you have an allergy to the drug. This is because the body builds up antibodies that instantly release chemicals into the body which cause red itchy rashes.

In most cases the reactions are mild and if they do occur then first-hand you should consult the medicine box/bottle/DOMAR where it will state any possible side effects on the leaflet or possibly on the main label ir you see on some pain medication ‘’Caution-May make sleepy do not operate heavy machinery’’ etc.

Mr BT has a medical history of hypersensitivity to penicillin, this indicates that he has a penicillin allergy. Penicillin allergy happens when the immune system reacts to the drug as if it were a dangerous substance instead of a helpful remedy. The immune system activates certain cells to produce immunoglobulin E (IgE) antibodies to fight the component of penicillin to which the patient is allergic too. Chemicals release by the immune cells can cause the signs and symptoms related with an allergic reaction. Penicillin is a simple structure and of low molecular weight. It has been identified that low molecular weight substances are able to illicit immune responses are called haptens. Alone, haptens cannot cause an immune response it must bind to innate proteins in the plasma and cell surfaces to form hapten-carrier complexes. Most haptens are the breakdown products which are isomers of penicillin (Neal & Michael, 2012). The beta-lactam ring is unsteady and when it binds to a protein it acylates lysine residues bring about in a penicilloyl epitope known as benzylpenicilloyl .These hapten-carrier complexes are recognized as antigen by IgE on mast cells and basophiles (Neal & Michael, 2012).

Laboratory: CK 41, aldose 5.7, CCP 5, rheumatoid factor 10.8, ANA negative, ANCA is less than 1:20, P-ANCA less than 1:20, hypersensitivity pneumonitis panel is negative, anti-Jo-1 is less than 0.2, scleroderma antibody is less than 0.2, IDE total 5. CBC within normal limits.

The patient points out a rash on the back of her neck that she states happened after

Prescription and over-the-counter drug use in America has increased steeply over the past fifty years. This is a cause for concern. Too often, these medications only treat the symptoms and not the underlying cause of the disease. And they all come with dangerous side effects. Adverse drug reactions are America’s fourth leading cause of death. Do not assume that OTC medications are safe. They can cause serious adverse reactions on their own and also interact with prescribed drugs to increase risk.

E.O's health care provider prescribed penicillin because it is an antibiotic used to treat many infections, but he is concerned about an allergic reaction caused by IgE antibodies. E.O's asthma history and allergic reactions to bee stings clue the health care provider into pondering that she might have Type 1 Hypersensitivity. If this is the case, E.O is at a high risk for an allergic reaction to the penicillin, because any previous exposure to penicillin might have triggered some immunity towards it.

We all know someone who has recognized with a reward or praise that they do not deserve. This is known as a trophy syndrome. My cousin Adrian Suffer from trophy syndrome. Some reasons are my uncle provided him everything he wants, as well, my uncle does everything for him. As a consequence, now that he is older my cousin believes that he has to have the things that he wants, instead of the things he have earned by his own.

Adverse reactions to this medication are migraine, speech disorders, rhinitis, sinusitis, hyperglycemia, elevated liver function, elevated serum creatinine level, pancytopenia, bronchitis, dyspnea, toxic epidermal necrolysis, anaphylaxis, elevated creatine kinase, generalized pain, and infection. Nursing considerations with this medication is to have the patient swallow the whole tablet and not to chew. Watch for aspiration while watching the patient take the medication. Educate the patient about the medication and inform them to notify a physician if bleeding

Medications that can cause interactions include anticoagulants, probenecid, bisphosphonates, angiotensin-converting enzyme (ACE) inhibitors, anticoagulants (Warfarin), antiplatelet medicines (Clopidogrel), aspirin, corticosteroids (Prednisone), heparin, other NSAIDs (Ibuprofen), Rivaroxaban, or Selective Serotonin Reuptake Inhibitors (SSRIs) (Fluoxetine) due to the risk of stomach bleeding may be increased. Bisphosphonates (Alendronate), Cyclosporine, Hydantoins (Phenytoin), Lithium, Methotrexate, Quinolones (Ciprofloxacin), Sulfonamides (Sulfamethoxazole), and Sulfonylureas (Glipizide) side effects may be increased by Naproxen. The effectiveness of Angiotensin-converting enzyme (ACE) inhibitors (Enalapril), Beta-blockers (Propranolol), or diuretics (Furosemide, Hydrochlorothiazide) may be decreased by Naproxen (Lexi-Comp,

Various eosinophilic conditions can give rise to gastrointestinal injury. Eosinophilia with gastrointestinal injury can be a result of drug induced liver injury secondary to drug hypersensitivity reaction, DRESS, eosinophilic gastroenteritis, among other causes. If history of drug use is present and there are manifestations of injury to gastrointestinal system, namely, hepatitis, pancreatitis or gastritis, a diagnosis of drug induced hypersensitivity should also be considered as a possibility.