Daily Administration Of T. Vulgaris By The Oral Route At A Dose Of 500 Mg / Kg

953 WordsNov 28, 20164 Pages
3. Results The study has established that daily administration of T. vulgaris by the oral route at a dose of 500 mg/kg for 10 days did not cause any mortality or any observable toxic effects in mice of GII. Mice were alert with no alternation of their behavioral pattern, any gastrointestinal tract disorder or respiratory distress. From the histopathological observations, there were not any observable changes in the livers at the giving dose compared to the normal controls (Figure 1). 3.1. Histopathological results Macroscopically, the liver of T. gondii infected group showed a mild degree of enlargement and focally extensive necrosis, however in T. vulgaris treated mice; the livers appeared more or less healthy. Microscopically, the livers of T. gondii-infected mice (GIII) showed focal areas of necrosis with a mild degree of inflammatory cellular infiltrate; mainly lymphocytes that were very obvious in the portal area and Toxoplasma cysts were observed between the hepatocytes (Figure 2). However, in the infected immunosuppressed group (GIV), the histopathological features of liver progressed from moderate to severe, in which there was a dissociation of hepatic cords pattern with generalized necrosis of the hepatocytes. Also, there was marked dilatation and congestion of the hepatoportal blood vessels. It was observed that some of Toxoplasma cysts ruptured, releasing tachyzoites to the sinusoids and invading the other hepatocytes and kupffer cells. Also, there was kupffer

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