Darier's Disease Essay

BB’s skin presents as pink, warm and dry. No obvious signs or symptoms of abnormal bruising or lesions present however, the patient states that the skin has of late has

What is Harlequin Ichthyosis? It is a rare severe genetic disorder that affects the skin. You’re usually born with this disorder; causing hard, very thick skin covering most of their bodies. The skin forms large, diamond shaped plates that are separated by deep cracks. This disorder is an autosomal recessive gene pattern. This means both copies of the gene in each cell have mutations. Both parents of an Infant with this disorder each carry one copy of the mutated gene. The parents typically do not show any signs or symptoms of the disorder. What could cause something like this to happen? Back in 2005, Scientist did a study that was traced to a mutation in the ABCA12 gene. This is believed to encode a transporter protein involved in the transport of fats across cell membranes. Some symptoms

The New England journal of medicine by Frank C. Powell, made interesting factual points about the skin disease of the integumentary system, rosacea. Rosacea is a common yet a very effective disease of the integumentary system. This skin disease effects patients physically and emotionally. Rosacea comes in all sorts of forms such as; ocular, papulopustular, and phymatous. These different types of Rosacea also come in different stages, stage one being mild, stage two being moderate, and stage three being severe. According to this journal Rosacea begins to effect people between the ages of 30 and 50 years old. Factors that bring on Rosacea are things such as heat, alcohol, sunlight, hot beverages, stress, menstruation, certain medications,

EB is a “life threatening” disease (Fallon). It can be inherited from a dominant gene or a recessive gene. A “mutation in the COL7A1 gene” can easily cause EB (Pausch). This deadly disease affects about 50,000 people in the United States. Children with this disorder can “lose fingers and toes” (Ezzell).Sometimes, it can affect lungs, the esophagus, eyes, nails, the mouth, teeth, and muscles. Scientists have discovered 23 types of EB. Scientists at the University of Chicago say that the mutation in the cells’ keratin causes blisters to appear by “weakening keratinocytes” so they get dissolved when they are touched (Ezzell). In other parts of the world, the disease would affect “one in 100,000” people (Fallon).

Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, circumscribed hypomelanosis of the skin and hair, with total absence of melanocytes microscopically.[1] Various physiological, biochemical, histochemical and enzymatic studies have been done to find out the cause of the disease.[2] Genes certainly play a role in all aspects of vitiligo pathogenesis, even response to environmental triggers, and so genetics really should not be separated out as a distinct phenomenon. [3],[4] In the past few years, studies of the genetic epidemiology of generalized vitiligo have led to the recognition that vitiligo is part of a broader, genetically determined, autoimmune, and auto inflammatory diathesis. [3],[5] The pathogenesis of this disorder is uncertain, but it appears to be dependent on the interaction of genetic, immunological, and neurological

This condition often occurs in individuals between the ages of 25 and 44, and is a result of a number of different factors including genetics, environmental factors,

This condition is caused by funguses called dermatophytes. The condition develops when these funguses grow out of control on the skin.

Choice “A” is the best answer. The lesion depicted is a melanoma. Classic warning signs and symptoms for a melanoma include any cutaneous lesion that changes color, size, or shape. Advanced lesions frequently become friable, tender, painful, crusted, or ulcerated.

One way to prevent complications is to not smoke (Badash 2015 p.1). When inside wear socks or gloves when going to put food in the freezer (Mayo Clinic 2015 p. 11). Stress may trigger a Raynaud’s attack as “blood vessels are normally constricted when someone experiences strong emotions” (Raynaud’s Association 2015 p.1). In an attempt to avoid this take time to relax and un-wind when one begins to feel high levels of stress. According to Badash (2015), when going outside wear layers and gloves to avoid an occurrence of vasoconstriction. When my patient is out of season for swimming she should exercise regularly (Badash 2015 p.1). However when it is swimming season the patient can run warm water on her hands and feet (National Institute of Arthritis and Musculoskeletal and Skin Diseases 2014 p.1) after getting out of the pool or when she is not in the pool as it triggers her Raynaud’s. According to NIAMS (2014), another way to prevent flare-ups is to avoid air conditioning. This is unrealistic so it is best to have gloves and socks, if necessary, when in air conditioning. If gloves are no available putting your hands on a warm area of the body is a good substitute (Badash 2015 p.1). These interventions should be effective because they work to keep the hands and feet warm, which leads to vasodilation (abpi 2015 p.1). If the patient desires to have more information the nurse can give them pamphlets or give them names of reliable

If lesions occur all over the body rather than in certain areas, seek immediate medical treatment as this could be a sign of serious problems.

Patch of writing skin across the nose and cheeks as well as hands and forearms (erythema)

This condition is distinguished by a mass of glandular tissue that measures approximately 0.5 cm in diameter with glandular

Tinea capitis and seborrheic dermatitis (dandruff) are scalp disorders characterized by scaling and itchiness related to fungal infection. Tinea capitis usually affects children and is spread by direct contact. The skin lesions appear as scaly patches on the scalp that are often associated with hair loss (alopecia). Lymph nodes in the head or neck may enlarge as a reaction to scalp infection, but usually resolve with clearance of infection.

This lack of protein is caused by a mutation in the gene which is where the mentioned variations of the disorder come in. The first type is autosomal dominant where the gene is taken from only one parent. There is then autosomal recessive where the gene is taken from both parents. However these are not the only types. A protein called keratin can be affected by a mutated gene from one parent creating the symptoms of the disease in a type called epidermolysis simplex. The same can happen when inherited from two parents in which they label junctional epidermolysis. The debate and misconception comes with the idea that this is not only a genetic disorder, but an immune disorder a well. This creates a controversy over whether it is preventable; however, it is luck of the draw when it comes to the one we are focusing on today, the genetic type. Often people that carry the gene resist the want to have offspring simply because they know the risks and effects of the crippling disease. We previously talked about the most common and broad symptom which is used crossed the board to determine the disorder, the peeling of the outermost layer of skin at the slightest touch, however, there are other and more fatal symptoms that many fail to consider.

Many people seem to think this means it is merely a minor annoyance, not a serious medical condition. This is not true. It is an autoimmune condition that impacts overall health, not just the skin.