Delivery of Low Molecular Drugs Using Chitosan and Its Derivatives

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Delivery of low molecular drugs using chitosan and its derivatives 1. Introduction The primary focus of this term paper consists of two parts. First, review chitosan-based drug delivery system for the delivery of traditional low molecular weight drugs based on a review paper titled “targeted delivery of low molecular drugs using chitosan and its derivatives” (Advanced Drug delivery reviews, 2010). Second, critique an original research paper about hydrotropic oligomer-conjugated glycol chitosan as a carrier for tumor-targeted paclitaxel delivery, which was published in Journal of Controlled Release in 2013 (title: Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery). Chitosan, a linear aminopolysaccharide composed of randomly distributed (1→4) linked D-glucosamine and N-acetyl-D-glucosamine units, is obtained by the deacetylation of chitin, a structural element in the exoskeleton of crustaceans, which is the second most abundant natural biopolymer after cellulose (Fig. 1). The most easily exploited sources of chitin are the protective shells of crabs and shrimp. The primary aliphatic amines of chitosan can be protonated under acidic conditions (amine pKa is 6.3). Fig 1. Chemical structure of chitosan Research showed that long circulating macromolecules (polymer–drug conjugates) and nano-sized particulates (such as micelles and liposomes) accumulate passively at the

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