Dementia With Lewy Bodies ( Dlb ) Essay

1551 WordsOct 9, 20167 Pages
Dementia with Lewy bodies (DLB), when cognitive symptoms appear within a year of movement problems, is a complex and challenging neurodegenerative disorder. (Pervin, Edwards & Lippa, 2016). It is complex because the DLB pathology and its impact on certain brain regions are unclear. The pathology includes Lewy bodies, senile plaques and neurofibrillary tangles. It is challenging because its many core features make it difficult for individuals to perform activities of daily living. The core clinical features comprise of declining and fluctuating cognition, behavioural and psychotic behaviours and spontaneous signs of parkinsonism. DLB main neuropathological structures are Lewy bodies, nevertheless it also has the Alzheimer’s disease (AD) pathology of senile plaques and neurofibrillary tangles (Pervin, Edwards & Lippa, 2016). Astonishing up to 80 percent of individuals can show AD pathology (Colom-Cadena et al., 2013). Lewy bodies are located in cell cytoplasm, spherical in shape, eosinophilic, neuronal attachments, with a compressed hyaline centre and clear halo. They are made of unusual shortened and phosphorylated proteins and alpha-synuclein is the main component (Hancock, 2011). The alpha synuclein accumulations, termed Lewy bodies (LB) and Lewy neuritis (LN), disturb brain chemicals resulting in complications with movement, thinking, mood and behaviour. In a fit brain, alpha-synuclein is essential in brain neurons, especially at presynaptic part, where cell

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