Dentinogenesis Imperfecta Research Paper

Pediatric Dentistry is the practice of dentistry from the moment of a child’s birth through to adolescence. In short, pediatric dentists work in promoting the dental health of children as well providing their parents with the educational knowledge in sustaining their children’s oral hygiene. Normally it is advised that a visit with a dental professional should occur within the first six months of the first tooth eruption or by the time of the child’s first birthday, with latter visits taking place every six months.

My job shadowing experience with Dr. D. Lance Taylor has helped me in learning about the quality of education and intensive clinical training conducted at the SIU School of Dental Medicine. In addition, the clinical certification course will aid in enhancing my knowledge and developing skills required to make a smooth transition into the class. More importantly, opportunities to serve at the Give Kids a Smile and Mission of Mercy clinics will help in continuing my passion for community service. Also, it will be a great opportunity to learn from the ongoing clinical research at the school and improve my critical thinking. I am particularly interested in the research of Dr. Nathalia Garcia about the role of biomarkers in the progression of periodontal

From the viewpoint of nurses who examine children in primary care settings, the history of baby bottle use and the physical examination can provide important clues. In particular, Beaulieu and DuFour (2000) point out that evidence suggestive of BBTD is the presence of a dull, white band of demineralized enamel along the gingival margin, usually found on the central incisors. Often all 4 maxillary anterior teeth are involved simultaneously.

Clinically, the oral findings were “high arched palate in all cases, malocclusion in 6 cases and macrostomia in 4 cases while multiple impactions of the teeth were detected in four patients” (Gataa, 2015, p. 7713). Additionally, only one patient had a cleft palate. From a radiographic perspective, all patients had zygomatic hypoplasia and seven patients had maxillary sinus hypoplasia. Many patients also had micrognathia and short ramus of the mandible. As only two patients had family history of TCS, six patients had TCS due to a new mutation. These results exemplify the notion that TCS patients are all affected differently, and with varying types and degrees of deformities, due to the fact that most cases arise from a new mutation.

Over 90 percent of osteogenesis imperfecta cases are caused by mutations in the COL1A1 and COL1A2 genes. These are the genes that provide instructions for making the proteins that are used to build type I collagen—the most abundant protein in bone, skin, and other connective tissues that provide strength, support, and structure to the body. Osteogenesis imperfecta type I is most often caused by mutations in the COL1A1 gene; specifically, genetic changes that reduce the production of type I collagen. This causes bones to be very brittle and fracture easily. As for OI types II, III, and IV, mutations in the COL1A1 and COL1A2 causes alterations in the structure of type I collagen molecules. This defect will weaken connective tissues, predominantly in bone, and result in the typical features of OI. The mutations in the CRTAP and P3H1 genes cause the rare and sometimes severe cases of osteogenesis imperfecta. CRTAP usually classifies type VII, and P3H1 classifies type VIII. The proteins that are produced by these genes work together to create the mature form of collagen molecules. The defects in these molecules lead to weakened connective tissues, which cause severe bone abnormalities and growth problems. Osteogenesis imperfecta types V and VII are found in people without identified mutations in their genes, making the cause of the disorder unknown. Researchers are continually working towards

Reversal of the normal relationship of upper teeth, which only interfere normal function to a minor degree (less than 2mm).

Witkop syndrome is manifested by defects in the nail plates of fingers and toes typically and hypodontia, with normal hair and sweat gland function. There is a pattern of missing teeth.8 Absent maxillary incisors, second molars, and maxillary canines are the most common missing teeth.9 Genetically, mutations in genes MSX-1, PAX9, PsITX2, LTBP3, WNT10A, EDA and EDARADD, AXIN2, and IKBKG have been found associated with oligodontia. Mutations in MSX-1 have been shown to be associated with Witkop’s syndrome.[10)

These genes both encode transcription factors. The genetic heterogeneity of dental agenesis presents a challenge when trying to connect various genes and their pathways to a specific phenotype.5 Third molar agenesis increases the risk of additional dental agenesis 13-fold.1 It also has the ability to delay development and influence size of other teeth within the dentition.1 There has yet to be a correlational study between third molar agenesis and other dental abnormalities.1 Individuals with third molar agenesis avoid the dreadful early adulthood invasive extraction that is common in our culture today. With that said, they may pay a price with other abnormalities in their permanent dentition. The goal of this study is to further identify genes involved specifically in third molar

Your first step is an evaluation of your child’s teeth, jaw, and bite. Dr. Takacs will thoroughly review treatment options with you and answer any questions

The teeth are the hardest substances in the human body. They are built for biting, grinding and chewing, teeth are composed with most prominent inorganic minerals like calcium and phosphorus. Every tooth is embedded in a socket called gum and are made up of four different types of tissue: enamel, cementum, pulp and dentin. The enamel which is the hardest, white outer part of the tooth covers the crown which is placed above the gum. The cementum, coats the roots of the teeth firmly to the gums and jawbone. At the very centre between dentin and cementum, called pulp, where connective tissue, blood vessels and nerves are located. Dentin makes up most the tooth, guarding teeth from the wear and tear of chewing, protects against temperature changes and

There are several different parts to a tooth. The enamel, which is the outer covering, protects the tooth. It is the hardest substance in the human body, and is non-porous. It is made mostly of calcium-phosphate and is irreplaceable due to being made of a non-living mineral. (WebMD, 2013)Underneath the enamel is the dentin. Unlike the enamel, dentin is made of living cells. Dentin is a tough layer of

Severe dentofacial/crainiofacial deformities affecting children can have an adverse effect on their function (eg, mastication, swallowing, breathing, or speech). Such deformities may require early surgical interventions in order to improve their quality of life. Despite going through these early surgeries, those patients and their parents must be made aware that additional surgery will probably be necessary later. Children with severely progressive congenital deficiencies affecting function/health should be distinguished from ones with sever developmental deformities that can be managed later in life. In this review, we will focus on growing patients with developmental jaw relationship abnormalities who seek orthodontic treatment, rather than patients with progressive congenital deformities affecting function and/or health.

Furthermore, a study involved six Japanese families with non-syndromic tooth agenesis. There was a novel nonsense mutation in exon 1 in a family with oligodontia. This mutation made a termination codon in the first exon, which led to truncated W139X at the C terminus and no homeodomain MH4. Missing MH4 resulted in losing DNA binding, protein-protein interaction, and nuclear localization

Humans spent thousands of dollars going to the dentists so we can keep using our teeth healthy and be able to chew on food that we eat every day. Teeth are earliest development and the lead to many other features. They were first seen in eel like vertebrate, the Conodonts that had armor teeth like structure that were made from the interaction of two skin layers. Also found in the ancient fish called Ostracoderms (Shubin, p.77). Its head were composed of tiny bone shield that were made from the teeth like structures. Teeth were developed to process food. The development of teeth was composed of two layers of the tissue in the skin. The protein in the outer layer of the skin produce enamel and the inner layer produces the dentine and the pulp inside the tooth (Shubin, p.78). The process of two

The most probable cause of the caries development is the increased acidity within the oral cavity, sugary foods and lack of proper attention to oral health. Dental caries is evident clinically through Jenny’s intraoral examination that reveals the patient has moderate restoration on her dentition – all molars present small amalgam restoration on the occlusal surface. There are also visible cavity on the 25 occlusal surface distal aspect and a suspicious shadow on the 26 mesially.