DERMATOFIBROMAS
Overview
Dermatofibromas (also known as Fibrous histiocytoma and Fibroma simplex, Nodular subepidermal fibrosis, Sclerosing hemangioma), are common noncancerous (benign) small skin growths. Dermatofibromas are typically detected on the arms and legs. Other common areas are located on breast, face and hands. This growth is usually a benign, single structure that resembles a nipple. Its appearance can be discolored and contains hard, scar-like tissue. A minor injury such as an insect bite, puncture or most recently discovered arsenic, can result in the formation of a dermatofibroma. These growths or nodes only can be found on humans and have not been reported or found other animals. It is estimated that only 1:10 women
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Arsenic is rapidly cleared from the body and often is undetectable after only a few hours. However, continuous exposure to arsenic can result in severe poisoning and multiple organ involvement. Arsenic is one of the most common pollutants and contamination of food and water is widespread and consumption is significant. Recent studies have linked a correlation between dermatofibromas and arsenic. One study suggested that the combination of dermatofibromas and arsenic caused the development of breast cancer. However, the exact cause in development of dermatofibroma is unknown but damage to the endothelial cells is commonly caused by arsenic exposure. Instead of the arsenic being excreted in eccrine glands, arsenic becomes deposited in a concentrated area of the body and built over a period of time causes the growth and development of …show more content…
Due to its physical characteristics (no odor, no color, and no flavor), arsenic exposure is often unnoticed, especially when ingested through drinking water. Therefore, the key to prevention of Dermatofibroma is understand the risk factors whether environment such as chronic arsenic exposure due to the ingestion of naturally-contaminated water, groundwater contamination due to leaching of arsenic from rocks and soil frequently results in concentrations above 50 mcg/L, which are associated with carcinogenesis in humans. Occupational exposure via inhalation of arsenic-containing vapors occurs during smelting, mining, refining, electroplating, and manufacturing of decorative-glass, pesticides, gallium arsenide computer microchips, and pressure-treated wood. Documented regions with natural groundwater arsenic contamination include Millard County, Utah; Lane County, Oregon; Lassen County, California; Fallon, Nevada; Fairbanks, Alaska; and New Hampshire, also persons living in the southwestern United States are at higher risk for being exposed to elevated levels of arsenic in drinking water. (Sarina B Elmariah MD PhD, Robert Anolik MD, Ruth F Walters MD, Karla Rosenman MD, Miriam K Pomeranz MD, Miguel R Sanchez MD, Dermatology Online Journal 14 (10): DOI: 10.1111/jdv.13092 24 19 July 2015, Invasive squamous-cell carcinoma and arsenical keratosis.). There currently is no concrete clinical-pathological evidence
Arsenic has been shown to cause cancer and deaths. However, the element is multifaceted because in other studies it has been shown to have a healing effect. Be that as it may, the component is clearly exceptionally equivocal in light of the fact that in different reviews it has been appeared to have a recovering impact.
Previous research has pointed out that the mechanism by which arsenic exerts its toxic effect is through impairment of cellular respiration by the inhibition of various mitochondrial enzymes, and the uncoupling of oxidative phosphorylation. Most toxicity of arsenic results from its ability to interact with sulphydryl groups of proteins and enzymes, and to substitute phosphorous in a variety of biochemical reactions
Also depicted in this paper is the type of cancers caused by each chemical and other related health problems associated with each chemical. Finally, the role of government agencies such as FDA, EPA and OSHA in preventing excessive amount or zero amounts of toxic chemicals from entering the environment will be discussed. The last paragraphs will enumerate the inferred conclusion from my research on Agent Orange, DDT and Benzene.
When it comes to treating acne, Asheboro Dermatology & Skin Surgery in West End, NC, has successfully treated patients with Accutane (Isotretinoin), a drug taken orally to help eliminate the redness, scarring and scabbing that’s often associated with the skin condition.
Copper is a naturally occurring element that can be found in all plants and animals. A certain amount of copper is necessary for health, and the human body has developed a way to maintain the proper level of copper in it (Minnesota). Even so, large concentrations of copper, and general long-term exposure, can have a negative impact on the body. Symptoms include stomachaches, vomiting, diarrhea, liver and kidney damage, and even death (Lenntech). Exposure to copper comes from many areas, but the most common one is through the water. Copper is commonly found in plumbing pipes, which can lead to high levels of copper in drinking water and fresh water sources due to erosion. Lakes and streams are also treated with copper to prevent algae overgrowth (Group).
- Tests determined increase levels of arsenic, selenium and other metals in the surrounding waters and in sediment nearby.
While nitrates are one of the major contaminants in the area, San Joaquin Valley residents face drinking water pollution from many other sources including arsenic, coliform bacteria, and pesticides. Arsenic is a naturally occurring semi-metal element that is found in different types of rocks. While arsenic primarily occurs naturally, human activities impact the amount of arsenic in groundwater. Arsenic is not only toxic at high concentrations, but also harmful after prolonged exposure at moderately elevated levels. California recognizes arsenic as a human carcinogen and believes prolonged exposure to the element to be associated with various cancers, including skin, bladder, kidney, lung, and liver cancers. A study in Maine found a connection between water contaminated
World War 1 began in 1914 and ended in 1918. The war was between the Central Powers which consisted of Germany, Austria-Hungary, and Turkey and the Allied Powers which was made up of France, Great Britain, and Italy. The United States remained neutral in the war until 1917. The United States entered the war because Germany was provoking them. Germany was provoking the United States by attacking innocent ships, and blowing up a munitions factory in New Jersey. The United States contributed to the Allied cause after joining the war by asking Americans to buy liberty
One of the most prevalent tumors or skin conditions in recent times is without doubt Seborrheic Keratosis. They may occur at any part of the epidermis and will in most cases exhibit considerable degrees of proliferation. This should quickly dispel other misconceptions that they tend to exist only in areas that are exposed to the ultra violet rays of the sun. Though these are the most common areas, they are not the only places they can be found.
Copper is another pollutant that at very high levels is toxic and can cause vomiting, diarrhea, loss of strength or, for serious exposure, cirrhosis of the liver (Pure Water Services). In order for copper to metabolized the heavy metal zinc is needed. Zinc helps with copper breakdown but too much zinc can cause a copper deficiency which can also cause problems such as anemia. While copper has some severe side effects there have not been any cases that are related to cancer. In most cases throughout the Silver Bow Creek copper is not thought to be a severe threat to the community.
There is a higher likelihood of being exposed to arsenic via food ingestion compared to inhaling arsenic-contaminated air or drinking arsenic-contaminated water. Once the arsenic has been absorbed through the lungs or gastrointestinal tract, the arsenic is distributed through the body via the bloodstream. For metabolism, in the blood stream, the arsenic becomes attached to the red cells, white cells, and cells that can convert arsenate to arsenite. Some of those arsenites are taken to the liver, where they are methylated by the enzymatic transfer of the methyl group from S-adenosylmethionine (SAM) and the arsenite are converted into methyl arsonate (MMA V) and dimethyl arsenate (DMA V). Those metabolites, methyl arsonate and dimethyl arsenate, are then ready to be excreted. If the liver is at its limit of methylation, excess arsenites are stored in the body’s soft tissues. Arsenic and its many variations (ie. MMA V, DMA V, arsenate, and arsenite) are excreted through the kidneys. There is a possibility that two to four weeks after being exposed to arsenic, some of the arsenic can still be found in the human’s hair, nails, skin, and bones and teeth (ATSDR,
These occur in all parts of the body but the communal areas such as neck, underarms, groin, under breast, thighs and sometimes on eyelids.
Also depicted in this paper is the type of cancers caused by each chemical and other related health problems associated with each chemical. Finally, the role of government agencies such as FDA, EPA and OSHA in preventing excessive amount or zero amounts of toxic chemicals from entering the environment will be discussed. The last paragraphs will enumerate the inferred conclusion from my research on Agent Orange, DDT and Benzene.
Some may peel and some liquid may appear on the surface. The spots usually sits on legs and arms but can spread.
The health hazards for humans who come in contact with contaminants from exposure to polluted water can have long term effects on the body causing possible organ failure and death. Contaminants and chemicals such lead and mercury can bring about many minor illnesses ranging from nausea, lung irritation, skin rash, vomiting, and dizziness, to the major diseases that include cancer, liver and kidney damage, disorders of the nervous system, damage to the immune system, birth defects and even death.