Describe And Explain Ethanol Catabolism Pathways In Humans,

While alcohol may have damaging effects to one’s body, many benefits exist if one drinks responsibly. Many studies and cases do show alcohol can damage the liver and other parts of the body; however, when one drinks in a moderate manner many health benefits may exist. Alcohol helps to fight against various health conditions and risks common among many people,

When consuming alcohol, individuals experiences the depression of the sympathetic nervous system resulting in a relax feeling. However, habitual consumption of alcohol can result in nerve cell death, impaired reactions and organ damage. After a year of alcohol use, individuals

The pathophysiology of alcoholism begins after alcohol the ingestion of alcohol. It is absorbed and unaltered through the stomach and intestines. Next it is distributed throughout the body through the blood and absorbed by all tissues and fluids (Huether, 2012, p. 72). Furthermore, in the liver the alcohol blood content is metabolized into acetaldehyde by the enzymes process of alcohol dehydrogenase (ADH), the microsomal ethanol oxidizing system (MEOS), and catalase (Huether & McCance, 2012). Next, the metabolizing effects the central nervous system (CNS) and exhibits a depressant action. It is first expressed in the subcortical structures of the brain. This has an effect of disorientation of motor skills and intellect. With an increase in blood alcohol concentration, the medullary centers become depressed and as a result affects respiration (Huether & McCance, 2012). In addition, the effects of alcoholism encourage hepatic and gastric changes. The hepatic effect is caused by acetaldehyde, in which, induces inflammation, fatty deposits and enlargement of the liver (Huether & McCance, 2012).

The body has no storage capacity for alcohol like it does for carbohydrates and fats. Since alcohol must be detoxified as quickly as possible, its oxidation takes priority over that of other macronutrients. In other words, while the liver is busy metabolizing alcohol, the utilization of fats, carbohydrates, and protein has to be temporarily suppressed. The burning of fat is suppressed the most, because it's at the bottom of the oxidative hierarchy.

Another enzyme, cytochrome, also participates in the metabolism of alcohol in the liver. Even though the greater part of alcohol consumed is metabolized in the liver, only a certain amount goes through this process in a given hour. This is related to the availability of enzymes in a given individual liver.

The pathophysiology of Alcohol affects virtually every organ system in the body. Therefore, consuming to much alcohol in high

Liver disease resulting from alcohol affects more than two million Americans and is one of the primary causes of illness and death. The liver frees the body of harmful substances, such as alcohol. While the liver breaks down alcohol, it produces toxins that can be even more dangerous than the alcohol consumed (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 13). “These by-products damage liver cells, promote inflammation, and weaken the body’s natural defenses. Eventually, these problems can disrupt the body’s metabolism and impair the function of other organs” (“Beyond Hangovers: Understanding Alcohol's Impact Your Health” 13). A condition called steatosis is the result of fat build up in the liver and is the

Drinking can cause physical harm to your body that can be long term. Alcohol can be taken into your system faster than your body can get rid of it. On average, with one standard drink your liver can only break down a certain amount of alcohol per hour. After a drink is swallowed, the alcohol is rapidly absorbed into the blood 20% through the stomach, and 80% through the small intestine, with effects felt within 5 to 10 minutes after drinking (“What happens when you drink alcohol?”). An average person is only around one standard drink, a liver can only break down a certain

Alcoholic beverages, deliver two main nutrients which the body metabolises – sugar and ethanol. Normally, low BGL stimulates glucagon secretion (from the alpha cells of the pancreatic islets) to bring BGL back up to stasis through glycogenolysis. And when BGL beings to rise, additional insulin is secreted (from the beta cells of the pancreatic islets) to bring BGL back down to stasis through glycogenesis. However, alcohol consumption inhibits the liver’s ability to do this – BGR is interrupted. This is because the body reacts to alcohol as a toxin, so its detoxification is prioritised by the body (all energy is spent on expelling it). The liver can’t multitask

~ Alcohol interferes with essential nutrients, it drains vitamins in body and slows absorption of new ones.

The physical effect of alcohol is irreversible, vital organs and body systems are severely damaged. For example, the pancreas sends enzymes to the small intestine in order to metabolize food. After consuming alcohol excessively over a long period of time, the pancreas will send out its

Alcohol has been found to affect the metabolism of cells within the body. The purpose of this experiment was to determine the effect of alcohol on E2F transcription factor proteins in HT-1080 cells. The method used to determine the effect of alcohol on E2F isoforms was western blot analysis. Image J was utilized in order to collect protein density data. This study found that the E2F3, E2F7, and E2F8 isoforms of the E2F transcription protein were significantly affected by alcohol. The increased presence of these isoforms due to alcohol has the potential to detrimentally affect the body. The overexpression of these isoforms could cause cell damage, a change in cell function, and the increased replication of DNA, which could lead to cancer. This

The physical results of drinking alcohol can be life-threatening. Within moments of ingestion, alcohol moves from the blood stream into every part of the body that contains water. (Vasap.state/effects.com November 30) This includes major organs like the brain, lungs, kidneys, and heart. (Vasap.state/effects.com November 30) Alcohol stimulates and agitates, depresses and sedates, produces

Alcohol has no beneficial attributes on a person’s health. Alcohol can have several harmful effects on human organs. Some organs in the human body that are damaged by alcohol consumption are the brain, kidneys, and liver. The human liver is the one organ that suffers the most damage. As stated in an article published by the National Institute on Alcohol Abuse and Alcoholism, “Because the liver is the chief organ responsible for metabolizing alcohol, it is especially vulnerable to alcohol – related injury” (NIAAA, 2005). Regular use of alcohol can lead to alcoholic liver disease (ALD). The severity of ALD can vary based on several different factors. Some of these factors include gender, age, the amount consumed, and how often alcohol is used. “ALD includes three conditions: fatty liver, alcoholic hepatitis and cirrhosis” (Alcohol Alert, 2005).

Alcohol is considered a food as well as a liquid because it contains calories but these are considered empty calories because there is no positive use that the body can get out of it. Alcohol though is very different in the sense that it is not digested like other foods. Normal foods are processed and carried into cells and tissues to be used as energy. Alcohol on the other hand goes directly into the bloodstream. It is absorbed mostly through the small