Designing A New Methodology For C Bond Formation

2305 WordsDec 1, 201610 Pages
The biaryl scaffold has received increased attention as a privileged structure by the Pharmaceutical industry.16 Over the last two decades, methods for preparing biaryls have relied predominantly on cross-coupling. The power of this method was recognized and won a Nobel Prize in Chemistry in the 2010, one of the biaryl compounds-biphenyl is shown in (Figure 8). Figure 8. Structure of Biaryl 1.5 Tellurium Chemistry Tellurium is a metalloid belonging to group VI in the periodic table. It has many applications in organic synthesis, alloys in machining process, and improves fabrication properties. Organotellurium compounds have much wide range of applications in metallurgy, agrochemical industry and material science.17 1.6 Research Objective The main aim of our research is to develop a new methodology for C-C bond formation by using diaryl, divinyl and dialkyl tellurides as starting materials. We are going to explore if these tellurium-containing compounds will undergo detelluration (removal of tellurium) reaction under palladium catalyst to give the biaryl, bivinyl or other C-C bond forming products. 2. RESULTS AND DISCUSSION 2.1 Synthesis of diaryl tellurides The symmetrical diaryl telluride was prepared using aryl iodide and elemental tellurium as the starting material with the aid of KOH as a base in the solvent of dimethylsulfoxide (DMSO). The
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