Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis, also called Lou Gehrig’s disease, is a neurodegenerative motor disease that results in the destruction of the neurons responsible for involuntary muscle movement (NINDS 2014). Patients are determined to have ALS if they have both upper motor neuron disease and lower motor neuron disease (Gordon 2011). Many people that have been diagnosed with ALS are seen in wheelchairs or if the person is in the early onset of ALS, using other walking devices. This is because in 65% of patients, ALS begins with weakness in the arms, legs, and body, therefore this results in the loss of capability to walk (Gordon 2011, A.D.A.M. 2012). Most patients live for approximately three to five years after symptom onset and usually die when the muscles in the chest stop working, which causes their heart and lungs to stop functioning as well (Gordon PH 2011, A.D.A.M. 2012). This is caused by muscles weakening until atrophy and fasciculations occur, leading to the brain being unable to control voluntary movement (NINDS). Amyotrophic lateral sclerosis is classified as a motor neuron disease (NINDS).
The nervous system is made up of neurons that take in information through our senses and then processes it to the rest of the body(IQWig 2012). After this, motor neurons send a signal from the nerve cell in the brain, to the brain stem, down the spinal cord, and cause a reaction in the muscular system (NINDS 2014). An example of this would be
ALS is also known as Amyotrophic Lateral Sclerosis is a disease in which the brain, nerves, and spinal cord deteriorate. It attacks every part of the body except the brain. Causing major body malfunction along with muscle weakening. Which includes lack of strength, the ability to move arms, legs and body, eventually you lose the ability to breathe. The average time of life after being diagnosed is two - five years. It was believed to be inherited or maybe an infection. After years of research scientist have found a major
Amyotrophic meaning, “no muscle nourishment” in Greek, lateral meaning where the neurons are in the spinal cord, and sclerosis meaning “scarring.” ALS, often known as “Lou Gehrig’s Disease,” named after the New York Yankee who first brought awareness to the disease in the late 1930’s, is a neurodegenerative disease, which affects the neurons in the brain. The nerve cells in the brain and spinal cord that are responsible for sending and receiving motor signals progressively die off, causing the deterioration of simple motor skills in patients with ALS, such as walking, talking, and eventually speaking and breathing, however thinking is not affected by ALS. Early symptoms cause the person to slowly lose mobility of limbs, but in a matter of a few years, the person loses the mobility of most of their body and will eventually lose the ability to eat and breath, which will ultimately cause death. ALS deteriorates the patient's body, however does not affect the patient's state of mind or sanity while the rest of the body shuts down. People usually get ALS between the ages of 40 and 70. However, there is a growing trend where athletes are getting ALS in their thirties. ALS can be contributed to genetic predisposition, which means that the gene that is responsible for ALS is already in the person’s DNA. In recent studies, however, it was observed that individuals who have had suffered multiple concussions or any other head trauma are
ALS (Amyotrophic Lateral Sclerosis) or Lou Gehrig’s Disease is a classified as a degenerative neurological disorder that inhibits motor neurons in the spinal cord and brain to function properly. This disease eventually results in paralysis and imminent death over a period of time. ALS patients have anywhere from a few months, to a couple years to live after diagnosis since their nervous systems are slowly destroyed, rendering the body useless, and sustaining life impossible.
The word “Amyotrophic” comes from the Greek language meaning “no nourishment”. ALS causes muscle weakness, problems with coordination, stiff muscles, loss of muscles, muscle spasms, over reactive reflexes, and fatigue. The symptoms of ALS increase rapidly, which makes an individual lose control of the muscles and begin having slurred speech. The arms and legs begin to feel weak and tired unexpectedly, while also experiencing cramps. When a medical professional diagnose someone with ALS they have about 2-5 years to live on average. Although about 10% of people with ALS live up to 10 years with the disease, while 25% live up to 5 years and 50% live up to 3 years. The average age that an individual is diagnosed with ALS is 55, but varies from the ages of
Amyotrophic Lateral Sclerosis (ALS) is a terminal disease, also known as Motor Neurons Disease, Charchot Disease and Lou Gehrig disease. ALS destroys the Central Nervous System (CNS) and causes damage to the upper and lower motor neurons in the brain. Signs and symptoms are characterized as: muscles weakness, muscle atrophy, twitching and reduced muscle reflexes. Eventually the patient will become paralyzed and rely on a tracheostomy and ventilator for breathing (ALS Association [ALSA], 2010).
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting both the upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord. It is the most common motor neuron disease in the adult population with a prevalence of two to seven cases per 100,000 individuals. Survival rates in persons with ALS show considerable variation. Five-year survival rates vary from 7% to 40%, whereas 10-year survival rates range from 8% to 16% (cite).
ALS stands for amyotrophic lateral sclerosis. This disease is a progressive neurodegenerative disease. A progressive neurodegenerative disease is a disease that will affect your brain and spinal cord. Since this is a progressive disease, you will deteriorate as time goes by. In order to move, the motor neurons in the brain reaches the spinal cord and then reaches the muscles throughout the body. ALS affects the motor neurons and since this disease is progressive, it will continue to affect the motor neurons by killing it until there is you lose control. Once you lose control of your muscles,it will start to atrophy or waste away from no nourishment. Since the spinal cord is the main part that signals and controls muscle movement, that
What is It? Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal age-dependent degeneration of motor neurons in the spinal cord, brain system, and cortex.39-12 A Plaracteristic of the disease is the loss of all voluntary motor function, with the exception of Ocular muscles and sphincter.8 The average age of onset is 55-60 years and the male to female ratio is 1.3 to 1.10 Following onset it is fatal after 3 to 5 years on average's once respiratory functions are paralyzed." It affects all races' I and is the most common of the human motor neuron diseases3'7' occurring in roughly one in every 2000 people." There are two types of ALS, sporadic and familial', with approximately 10% being
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease (ALS Association, 2016). A neurodegenerative disease is a disease in which nerve cells are damaged or killed. In this particular case, the damaged motor neurons affect voluntary movements (Newton et al., 2000). Amyotrophic lateral sclerosis, commonly known as ALS for short, got its name from the Greek language. By breaking the name into a-myo-trophic; “a” means no, “myo” refers to the muscle cells, and “trophic” refers to nourishment (ALS Association, 2016; Gulli & Veillette, 2002; Hains, 2006). “Lateral” indicates the area of the spinal cord where the nerves are being affected (Gulli & Veillette, 2002). “Sclerosis” refers to the scarring and hardening of the spinal cord
Amyotrophic Lateral Sclerosis – also referred to as Motor Neurone Disease in most Commonwealth countries, and as Lou Gehrig's disease in the United States– is a debilitating disease with varied etiology characterized by rapidly progressive weakness, muscle atrophy and fasciculations which is a spontaneous contraction affecting small number of muscle fiber. This is often referred “Lou Gehrig’s disease”. Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. Muscle cramps and muscle twitching all happens when people have ALS disease. First it damages the spinal cord pathway and through the motor neurons, bodies to move and is made up of the brain, nerve, and muscle. The things that we do every day like running all of that is controlled by the neuromuscular system. By the time that passes by the ALS disease causes these motor neurons in the brain and spinal cord to shrink and goes away, so muscle no longer receive signals to move. The result of this is that the muscle becomes smaller and weaker. About 2 out of 100,000 people will get Lou Gehrig’s disease. 5 out of 10% ALS cases in the United State are in Hereditary, means the disease runs through a certain families. At least 90% of cases are not inherited, this disease is called the Sporadic ALS disease.
Amyotrophic Lateral Sclerosis, ALS, or Lou Gehrig's Disease, named after the famous New York Yankees player Lou Gehrig, who was the first to be openly diagnosed with this disease, is a disorder that affects the victim’s ability to move or function and takes control over a long, painful period of time. It has many causes, including gene mutations, chemical imbalances of glutamate, which is a chemical messenger in the brain, disorganized immune response (in other words, the acids in the immune system eat away at the body’s normal cells), and mishandled proteins during development. It can be diagnosed through an electromyogram, or an EMG, a nerve conduction study, an MRI, blood or urine tests, a spinal tap, or muscle biopsy. ALS affects the motor
ALS is a specific type of motor neuron disease, where there is degeneration of the motor neurons in the primary cortex (Wijesekera & Leigh, 2009). Damage can also occur in the spinal cord. More often than not ALS is fatal, due to complications which arise. It is categorized under a few different titles including Lou Gehrig disease, Charcot, and Motor Neuron disease (Wijesekera & Leigh, 2009). This is the disease that affected famous baseball player Lou Gehrig. Throughout the course of the disease, individuals will experience increasing paralysis. The age of diagnosis is generally around 60, with individuals living only a couple years post diagnosis (Wijesekara & Leigh, 2009). There is a form of ALS, which individuals are known to live longer than 10 years, which is resistance (Atchinson & Dirette, 2012). The disease can actually occur around 17 years old, even though the symptoms aren’t diagnosed until much later (Atchinson & Dirette, 2012).The disease
The nervous system is made up of neurons, or nerve cells. The neurons communicate with each other by receiving and transmitting electrochemical signals, called neurotransmission. All human behavior is made possible by the activity of individual neurons working together in the
The manifestations of ALS are caused by the location of motor neuron death. When upper motor neurons die, the symptoms include problems controlling fine movements, spasms, dysphagia, dysphonia and dysarthria (Porth & Matfin, 2009). “Manifestations of lower motor neuron destruction include fasciculations, weakness, muscle atrophy, and hyporeflexia” (Porth & Matfin, 2009, p. 1284). Patients with early signs of ALS usually complain of feeling weak on one side, which is due to the slowing of electrical impulses to that group of muscles (Ignatavicius & Workman, 2010). Since the impulses are slowed, they are not receiving adequate electrical stimulation to move and the person feels weak. As the disease progresses, all the motor neurons die and are not regenerated so, the patient is left paralyzed, losing the ability to speak, swallow and breathe (Ignatavicius & Workman, 2010).
The nervous system is critical for human survival. The human nervous system is responsible for signaling bodily functions, sensory experiences, and information processing. The nervous system consists of three major structures: the brain, the spinal cord, and the peripheral nervous system (Brodal 1-18). The brain, spinal cord, and peripheral nerves are responsible for different processes and have unique structures. The brain is divided into three substructures: the cerebrum, cerebellum, and brain stem (Nieuwenhuys, and et al). The spinal cord is a bundle of nervous tissue that extends from the brain; the spinal cord and brain together compose the central nervous system (CNS). The peripheral nervous system are the nerves that are outside of the CNS, and are responsible for connecting the CNS to organs and the limbs of the human body (Brodal 1-18). Although each structure is unique, they all consist of nerve cells called neurons, which are considered the building blocks of the nervous system and are composed of dendrites and a single axon (Gartner and Hiatt 186-218). The structure of the neuron empowers the nervous system to interpret all incoming information, such as a smell, pain, or taste, and is responsible for sending critical nerve information that initiates such functions as breathing and heart rate, all of which are essential to human vitality.