Literature Review: In the article, “A simple and cost-effective HPLC-UV method for the detection of levetiracetam in plasma/serum of patients with epilepsy,” by Engelbrecht, Grobler and Rheeders, the concentration of levetiracetam was determined using HPLC with a diode array detector. Levetiracetam is a common treatment for epilepsy. Patients have to go through regular blood tests to ensure the drug is working to optimal efficiency and is not taken in toxic levels. For the experiment, the researchers used and Agilent 1200 HPLC with a degasser, binary pump, thermostatic oven and diode-array detector with varying wavelengths. The column used was a Venusil XBP C18, 250 x 4.6 mm, and 5 µm particle size. The column was protected by a guard precolumn with a graphite filter. The flow rate of the mobile phase was 1 mL/min. The mobile …show more content…
By making a calibration curve using different dilutions of a capsaicinoid stock solution, the concentrations + standard deviation of capsaicin and dihydrocapsaicin in the hot sauce sample was determined to be 48.922 + 0.226 ppm and 6.118 + 0.272 ppm, respectively. The concentrations were then converted to Scoville units resulting in mean heat ratings for capsaicin of 133,903 Scoville units and 16,747 Scoville units for dihydrocapsaicin. The total heat rating + standard deviation was 150,648 + 917 Scoville units. Before correcting the heat rating for 7.22% analyte lost, the total heat rating was 141,717 + 897 Scoville Units. The amount of analyte lost was minimal and didn’t significant affect the results. Both heat ratings correspond to Haban ̃ero, Scotch Bonnet and Jamaican Hot peppers. The hot sauce analyzed was Tabasco Haban ̃ero sauce. The total heat rating for the experiment agreed with the heat rating of the Haban ̃ero pepper that was used to make the Tabasco
In this experiment, hydrochloric acids at different temperatures will be used to observe the effect of temperature in dissolving Alka Seltzer tablets. Four different temperatures as 25 degrees Celsius, 45 degrees Celsius, 65 degrees Celsius, and 85 degrees Celsius will be arranged before the experiment by using a heating pad. 25 degrees Celsius indicates the average room temperature and equal increases will be chosen to observe different responses of Alka seltzer to different temperatures.
Capsaicin is a chemical that is found in chili peppers which causes the heat when you eat spicy foods. In order to detect the capsaicin that is found in the foods that you eat, your body has receptors on sensory neurons. The receptors are known as capsaicin receptors and found in the dendrites of the sensory neurons better known as nociceptors. (Caterina) When your body receives that feeling of pain or heat, it is due to capsaicin receptor recognizing capsaicin, but also the ability of the capsaicin receptor to act as an ion channel, which is found in a category known as the transient receptor potential channels. (Fox) Capsaicin will stimulate and excite the capsaicin receptor. When the receptor is excited it allows the entrance of Calcium (Ca+2) and Sodium (Na+). (Fox) When the calcium and sodium rush into the cell it will cause the cell to depolarize. Once the cell depolarizes, it will cause the action potential. The action
Choosing an appropriate antiepileptic drug is the key to successful medical management of epilepsy in children. The choice of antiepileptic drug depends on several factors, of which the most important is accurate seizure classification. The other factors used to choose an appropriate antiepileptic drug include the side effect profile of the drug, The available age- and patient-appropriate preparations of the drug, Whether therapeutic levels are needed quickly or not (depending on the frequency and severity of the patient’s seizures), and the patient’s comorbidities.
Nagaland of India contains one of the world’s hottest chilies – the Naga King Chili (Bhut Jolokia). The author of the article, Mary Roach, arrived to Nagaland to experience the Hornbill Festival, in particular, to watch the Naga King Chili-Eating Competition. She aimed to find out and understand the pleasure and pain the Capsicum genus brings to the people who consume it. The Naga King Chili Pepper varies in heat, but can score extremely high on the Scoville heat unit. The contestants of the chili-eating contest began to suffer from the effect of the capsaicin in their digestive tracts. Some experienced hot flashes and unbearable heat from
Prevalent to current day most employers require pre drug screening requirement so it wouldn’t make an exception on a government employee. It is however important to note that a police officer is held to a higher standard than civilian population because they of their positions to protect and serve. This helps create a basis of understanding of potentials for random drug screenings unless certain conditions are applied on and off duty.
AIM: To extract codeine and paracetamol from its tablet by solvent extraction and tentatively identify in comparison to standards using Thin Layer Chromatography.
It is an enduring woody climbing liana. It is local to India, Indonesia, Malaysia, South America and West Indies but at the same time is generally developed in the tropical areas. Black pepper is a general table sauce used to flavor a wide range of foods around the world. It is dedicated as the 'Ruler of Spices' (Srinivasan, 2007; Mathew et al., 2001). The fiery taste is fundamentally because of the nearness of a compound Piperine. Piperine is an impactful alkaloid (Tripathi et al., 1996) that improves the bioavailability of different basically and remedially assorted medications. (Khajuria et al., 2002). It likewise contains little measures of safrol, pinene, sabinene, limonene, caryophyllene and linaonol compound.
Symptomatic epilepsy is when there is a known reason as to why seizures are occurring. This may include, stroke, brain injury, an illness, improper development of the brain, or even a tumor. When the cause of epilepsy is believed to be due to genetics, it is called idiopathic. Cryptogenic epilepsy is when there is no apparent cause (Epilepsy Society 2016). Fortunately, there are over twenty anticonvulsive medications available today to help individuals with epilepsy manage their everyday lives. Unfortunately, one-third of those diagnosed with epileptic seizure disorder do not respond to the medication. Pharmaceutical intervention and the invention of antiepileptic drug was a breakthrough for individuals diagnosed with epileptic seizure disorder. Anticonvulsive pharmaceutical therapy has many different forms. It can come in the form of an oral supplement, suppository, or injection. Once the medication makes its way into the body, it has to make its way to the brain in order to be effective. In order for the medication to reach the brain, it has to be absorbed in to the blood steam. Once in the blood stream the brain can utilize the chemical compounds the medications release. Different anticonvulsant drugs targeted different four agents in the brain, sodium ion, calcium ion, GABA system and receptor agonists, and glutamate receptor antagonists. Sodium ion channels are
Hello Colleague! I hope you are having an amazing day! I am very excited that you are leading the clinical trial investigating the co-administration of Levothyroxine. I am happy to help in your understanding of why Levothyroxine is less effective when take in combination with calcium carbonate as opposed to calcium carbonate, which causes minimal interference with Levothyroxine in the body. In order to truly understand what allows Levothyroxine to be effective in treating hypothyroidism we must understand its chemical properties.
1.Levothyroxine is a thyroid hormone replacement used to treat hypothyroidism. It is a synthetic form of T4 and has the molecular formula: C15H11I4NO4. Levothyroxine is used when the thyroid does not produce enough thyroxine on its own. It can also be used to prevent an enlarged thyroid gland (goiter).
Anticonvulsants have an edge with rapid-cycling and mixed mood states (e.g. depression with racing thoughts). Except for gabapentin (Neurontin) and lamotrigine (Lamictal), they require blood tests. Carbamazepine (Tegretol) is monitored with blood levels; also CBC, platelets and liver function tests. Valproate (Depakote) requires CBC, platelet count and liver function tests; blood levels may be helpful. Lamotrigine (Lamictal) requires caution because of its association with a rare but dangerous skin rash (exfoliative dermatitis); risk can be minimized by starting with low doses and increasing gradually. Use lower doses with medications that slow lamotrigine metabolism (e.g. valproate). Gabapentin is generally safe and does not require blood tests.
One man is left dead and three other people are facing brain damage after they volunteered taking part in a drug test in Paris. 90 volunteer were given the drug in varying doses, and six of the volunteers have been hospitalized. All of the other volunteers are being contacted and tested for the same conditions.
The species is a source of popular sweet peppers and hot chilis with numerous varieties cultivated all around the world. Hot peppers are used in medicine in Africa and other countries. It is employed in medicine, in combination with Cinchona in intermittent and lethargic affections, and also in atonic gout, dyspepsia accompanied
Transient receptor potential cation better known as the capsaicin receptor and vanilloid receptor.It is a protein that is in humans which is encoded by the gene.This type of protein is a member of TRPV.It was the first member of the transient receptor potential and vailliod receptor.Aslo they are compounds which process through a vanillyl group.This drug is responable for the pungency of capsicums.Also for the burning sensation experienced after eatting spicy peppers.What is the history? Perspectives opened from cloning capsaicin receptor.They are outlines ,long lasting functional ,ultrastructural and nerve terminal effects.It affects the transient receptor potential vanilloid.Which invloves in sensing heart, warmth and most
The objective of the study was to compare the synergistic antibacterial activity of Ciprofloxacin (CF) in presence of selected ethanolic herbal extracts and cow urine distillate. In this study antibacterial activity of ethanolic extracts of pepper (P), turmeric (T), zinger (Z), drumstick (D) and Cow urine distillate (CUD) were tested against ATCC strains of Staphylococcus aureus, Klebsiella pneumonia and clinical isolates of Pseudomonas aeruginosa and E-coli by cup plate diffusion method. Results showed that the test samples did not show any antimicrobial activity alone. However in combination with drug showed significant activity. Amongst the test samples combination of CF and P, CF and CUD, CF and Z and CF and T showed 5 to 50% increase activity when compared to the control. Further, tablets produced in combination with drug and test samples showed increased antimicrobial efficiency than the CF drug alone. Further, no drug excipient interaction was recorded. It can be concluded that ethanolic extracts of P, T, Z and CUD acts as bio-enhancers and use of such bioenhancers along with drug could improve the efficiency and can minimize the dose related adverse effects. Bioenhancer activity order found in Pepper > CUD > Turmeric > Zinger. All bioenhancer are more active in Klebsilla pneumonae than Escherichia coli, staphylococcus areus, and Pseudomonas aeruginosa.