Determination Of Risperidone Essay

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3.6 Interferences study The influence of various substances as compounds potentially interfering with the determination of risperidone was studied under optimum conditions with 300.0 μM risperidone at pH 7.0. The potentially interfering substances were determined from the group of substances commonly detected with risperidone in pharmaceuticals. The tolerance limit was specified as the maximum concentration of the interfering substance that caused an error of less than ±5% in the measurement of risperidone. According to the results, neither a 1000-fold excess of methanol, ethanol, NH4 +, Fe2+, Fe3+, Mg2+, Fe2+, Fe3+, SO42−, Al3+, SO42−NH4 +, Fe2+, Fe3+, CO32−, Cl− or F−, CO32−, alanine, phenylalanine did not affect the selectivity, nor a 50-fold excess of levodopa, carbidopa, methyldopa, epinephrine, norepinephrine and methylphenidate interfered with the determination of risperidone.…show more content…
The results for determination of the risperidone and methylphenidate in Risperidone tablet and Ritalin tablet are presented in Table 1. Satisfactory recoveries of the experimental results were determined for risperidone and methylphenidate. The repeatability of the method was indicated by the mean relative standard deviation
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