Development And Isolation Of Bioactive Component From Endophytic Fungi On Musa Paradisiaca As Anti Diabetic Agent

Natural products used to treat many diseases for a long time. Natural products derived from many sources such as fungus like Piptoporus betulinus, which is used as an antiseptic and disinfectant and plants like Alhagi maurorum, which is used to treat anorexia, constipation, dermatosis, epistaxis, fever, leprosy, and obesity. (1) In this research, we will focus on one natural product derived from a plant called Serenoa repens. Serenoa repens also called Saw palmetto, is a plant grows up to 1m in width and 3m in height. Each part of it has different uses, for example, its leaves are used to make thatching, baskets, fans, brushes, brooms, rope, fire kindling, fish traps and dolls and its berries are used as food and as medicine. There are many

The use of natural products as medicine has initiated the isolation of active compounds. The first commercial pure natural product introduced for therapeutic use is generally considered to be

Also, with increasing incidence of diabetes mellitus in rural population throughout the world and due to adverse side effects of synthetic medicine, there is a real need for development of indigenous, inexpensive botanical sources for anti-diabetic crude or purified drugs for treatment of disease [5].The toxic level of the drug is assessed for fixing efficient drug dosage which is nontoxic without any mortality. The effective drug dosage (LD50) is considered for further Biochemical parameter studies using Wistar rats [Ref - HINDAWI].

Traditionally, the root of A. racemosus has been widely used to increase fertility and libido, cures inflammation of sexual organs, enhances ovulation, prepares the womb for conception and prevents miscarriages (Kalia et al., 2003; Naik, 1988; Dwivedi & Tewari, 1991). Although, A. racemosus roots also known to possess estrogenic property (Tewari et al., 1968), but it has also been documented that at higher doses of A. racemosus, it maintains the balance between the endogenous female sex hormones (Sharma and Bhatnagar, 2011). Moreover, the ethno medical use of A. racemosus root as an anticonvulsant has been experimentally validated in our laboratory (unpublished data) as well as by other researchers too (references). The available literature reveals that the plant has not been explored with respect to its therapeutic potential as an anticonvulsant in catamenial epilepsy. But nowadays the virtual screening of the phytochemicals is believed to be a major tool for drug discovery beyond their ethnic use. Hence, an effort has been made to explore the pharmacological activities of Asparagus racemosus root using Prediction of Activity Spectra for Substances (PASS) and Pharmaexpert. In line with in our current study, a PASS based analysis (Table 1 & 2) revealed the presence of different bioactive phytoconstituents which might be responsible as an anticonvulsant with the most significant possibility of getting effective in the management of catamenial

Type 2 diabetes is a serious metabolic disorder, which prevents the body from producing enough insulin to breakdown sugars from food to be used as energy. diabetes can have terrible effects on the body and is the sixth leading cause of death in the United States (Dey, 2011, pg. 231). Being that it is also the most common metabolic disorder in the world today many researchers have begun looking into possible solutions to this disease. One team includes that of Mohammadreza Vafa, Farhad Mohammadi, Farzad Shidfar, Mohammadhossein Salehi Sormaghi, Iraj Heidari, Banafshe Golestan, and Fatemehsadat Amiri, who researched how cinnamon effected diabetic patients. The

The study of cancer has impact millions of lives and scientist have continued to research new treatments for this disease. Scientists are coming close to developing a cure for this disease. New compounds are being tested to develop this cure. Compounds used in this research are Onosma echioides L., German Chamomile (Chamomilla recutita), and Rosemary (Rosmarinus officinalis L). Onosma L. is a medicinal plant traditionally used as laxative, anthelmintic and for alexipharmic effect. Chamomile have many medicinal attributes, used for hay fever, inflammation, muscle spasms, menstrual disorder, insomnia, ulcers, wounds, gastrointestinal disorder, rheumatic pain and hemorrhoids. Rosemary is a medicinal plant, a good source of iron, calcium,

Since the plant has many uses, the researchers come up with the idea to test the diuretic activity of the extract of the balloonvine leaves as a substitute to synthetic diuretic drugs. As what have the group discussed that this study

The African slave cultures in Suriname practiced the art of drinking bitter tonics, an African medicinal mixture used to enhance male sexual power and prevent disease by making the blood bitter. “The treatment of CBS often includes the use of medicinal plants...treating conditions with known plant species, which may be brought from the homeland or are also present in the new environment, and…adapting plant use and resorting to novel species in the new environment that may be similar to known species from the homeland” . In this article, a study was conducted comparing associated plant use to help cure ailments for the different African slave populations in Suriname.

According to world health organization, medicinal plants would be the best source to develop a variety of medications. Lots of medicinal plants with antidiarrheal properties have been widely used by the traditional healers; however, the effectiveness of many of these anti-diarrheal traditional medicines has not been scientifically evaluate. About 80% of individuals from developed countries receive traditional medicines including compounds derived from medicinal plants (11, 12).

Several botanicals, including Crataegus oxycantha, Terminalia arjuna, Inula racemosa, and Astragalus membranaceus, have been found to have therapeutic benefit for the treatment of cardiovascular disease. Crataegus oxycantha has been used traditionally as a cardiac tonic and current uses include treatment for angina, hypertension, arrhythmias, and congestive heart failure. Animal studies have also indicated that Crataegus extracts may also have potential use as anti-ischemic and lipid-lowering agents. The bark of the Terminalia arjuna tree has a long history of use as a cardiac tonic as well, and has been indicated in the treatment of coronary artery disease, heart failure, hypercholesterolemia and for relief of anginal pain. Additionally, it

Although, classical oral antihyperglycaemic agents are the mainstay treatment of type 2 diabetes, they fail to prevent diabetic complications (Bergenstal, Bailey, & Kendall, 2010). This, therefore, justifies the search for more efficacious drugs. Although modern medicine has provided drugs belonging to classes including thiazolidinediones, GLP-1 mimetics and DPP-IV inhibitors (Krentz, Patel, & Bailey, 2008), there is still a need for new agents with better potential and physiological antidiabetic actions for the treatment of diabetes. Therapeutic potential of phytochemicals in the management of many human diseases, including diabetes, have been widely acknowledged. However, scientific studies assessing the potentially

Now, there are still a lot of misconception for some people 's understanding diabetes, they think the blood sugar back to normal cure and blood sugar drops too quickly as possible is will be done, but these incorrect understanding easily bring negative impact to the prevention and treatment of diabetes. In the medical field, it is a group of diabetic hyperglycemia characterized by metabolic diseases. Hyperglycemia is due to defects in insulin secretion or action of biological damage caused, or both. Longstanding diabetes high blood sugar, leading to a variety of organizations, particularly chronic damage to eyes, kidneys, heart, blood vessels, nerves, and dysfunction. That

Herbal medicines are great alternative for commercially manufactured medicines available in the market. The major reason why herbal medicine differ from modern medicine is because they are produced with 100% natural content. Therefore the plant extract has all the medicinal values that are as effective as modern medicine. Commercially prepared drugs show results quickly but have numerous side effects. However herbal medicines don’t show any side

The plant Saraca asoca has been used in various traditional medicine systems and has been reported to be pharmacologically active against various pathological states. Bark, Flower and Seeds are used traditionally for the treatment of various diseases and aliments. S.asoca is used in many pharmacological activities like anti-cancer, antimenorrhagic, anti oxytoxic, antimicrobial activity and have extend uses in ayurveda, unani and homeopathy system of medicine. S.asoca is available as various marketed formulations such as Ashokarishta, Ashokkwath, Seed powder, Flower powder, Ashokghrita, decoction, pill, paste, herbal wine, syrup, capsules etc containing bark extract (Hegdea et al., 2007).

Plants have been the basis for the medical treatment of the most complicated health issues through much of human history ,and the traditional practices have become a need and a boon to the society .