Diabetes

There is a device called the bionic pancreas that is being developed by Ed Damiano, whose son, David was diagnosed with diabetes in 2000, gave him the inspiration to find a cure. For nearly fifteen years he has been researching and working on this project. There have been hundreds of successful trials of people with diabetes using the bionic pancreas and the feedback has been mostly positive. Some say the device as life changing. “At the end of one recent trial, an 11-year-old boy liked the bionic pancreas so much that he ran away from the investigators conducting the test, and it took them over an hour to get the device back" (Sifferlin 42+). There has been progress in all types of people. Sifferlin says "The bionic pancreas has successfully worked in people ages 6-76 and weighing 47 lb. to 283 lb." (42+). The bionic pancreas does also have a pain free, easy method of glucose testing since the device checks it continuously. The only requirement for the device to work properly is simply punching in the person's weight (Russell et al. 2148). Unlike the bionic pancreas, islet cell transplantation is limited in becoming a global treatment because of the lack of supply of islet cells. This is due to the fact that there are more people with type 1 diabetes than there are donor pancreases (Islet Transplantation). The bionic pancreas does not have limitations on the device itself that would prevent it from being produced all over the world. In other words, with proper funding the bionic pancreas can be produced for all diabetics. Damiano hopes to have the bionic pancreas affordable and on the market by

Type 1 diabetes is a disease that is most commonly diagnosed in children, is rarely diagnosed in adulthood, and “Diabetes at a glance” (2016) reveals that nearly two million people were newly diagnosed with the disease in 2016 in the U.S. alone, and one of the people included in that two million is myself. Throughout the

The cells used for this experiment were beta cells; diabetes is a beta cell disease, the body’s immune system turns against these cells in Type 1 diabetes and destroys nearly all of them. Without this source of insulin, the body can’t control blood sugar levels.

cells which can help treat people suffering from diabetes. Even tissues can be grown again by

Heart disease, cancer, and diabetes have drastically hindered, or even taken the lives of people you may know and love. While these three diseases consistently rank in the top ten leading causes of death in the United States, we as a country are steered toward pharmaceutical drugs in order to alleviate pain and ultimately mask their life altering effects on us. Adult stem cells is the future for diseases such as these. Up until now, the research from biologists combined with real life medical procedures in the adult stem cell field has put mankind within sight of remarkable success. Everything from reversing disease to lowering the cost and failures of pharmaceutical testing, is entirely possible with adult stem cells. The United States

Initially the results of islet cell transplantation were dismal but after the induction of glucocorticoid free immunosuppressive therapy and the use of adequate number of islet cells from multiple donors, showed a significant improvement in β – cell function with insulin independence 9. However, islet cell transplantation has its own limitations viz-insufficient supply, technically demanding and use of life -long immunosuppressive therapy in the recipients and progressive insulin dependence. These shortcomings can be overcome by the use of stem cells, which is an inexhaustible source of β –cells.

Stem cells can allow scientist to grow to replace tissue damage from heart disease, treat spinal cord and brain injury and could possibly treat serious diseases like diabetes, Parkinson's and Alzheimer's (source 5,7,9,10). While treatment, diagnosis and prevention of diseases have consistently been changing and finding new alternatives, stem cell research could be able to come up with a new approach in medicine that will be more comprehensive, integrated and highly individualized (source 10). Stem cell research can advance medicine dramatically and help much more people with critical

Approximately 445 million dollars are spent on acute hospital stays for chronic obstructive pulmonary disease in Canada, not including ongoing care and prescription drugs (Leading Hospitalization Costs in Acute Inpatient Facilities in 2012–2013). A majority of this money is spent on treating patient’s symptoms, not their condition. A use for stem cells and regenerative medicine is to treat asthma, “Since it has been described that asthma is a disease of T cell hyperactivity and scarring, hMSCs may provide a viable multiaction therapeutic either directly through cell contact or through the production of bioactive factors,” (Bonfield). Despite asthma being a common condition, it follows people their entire life, and results in less productivity during a flare up. The use of stem cells to treat asthma may limit the prescriptions required to prevent a flare up, as well as allow easy breathing for asthma patients. Diabetes is a growing problem in society; however, stem cells may be able to correct the absence of insulin: “with in vivo virus-mediated expression of specific transcription factors in differentiated pancreatic exocrine cells resulting in the reprogramming of these cells into pancreatic β-like cells.” (Atala). While this new innovation could save the government money on insulin, it could also improve the quality of life for millions, and eradicate diabetes. Another application of stem cell research is to treat leukemia: “Another promising approach is the isolation and genetic modification of patients’ cells to target or enhance the efficacy of a cellular therapy. One example of this approach is the development of targeted immunotherapy for B-cell malignancies.” (Atala). This approach can counteract the irregularity of the blood cells, and provide a cure to this cancer. With the current knowledge of stem cells their curative potential seems

There are over three million Americans that have already been diagnosed with type 1 diabetes, and another 15,000 children and 15,000 adults being diagnosed each year. Although frequently overshadowed by the better known type 2 diabetes, type 1 diabetes is an autoimmune disease that is not caused by “being fat” or “eating unhealthy” as many would ignorantly infer. Type 1 diabetes, however, is caused by the attacking of the immune system on the pancreas, denying it the ability to carry out its most important function, producing insulin to help control one’s blood glucose levels. For over a decade now, biomedical engineers, scientists, and doctors have been working diligently and effectively on creating a closed-loop

The Diabetes Treatment written by Sheriff Sheik Abdulazeez discusses the major health concern of diabetes. This is a deadly disease; it accounts for 5% of deaths around the world annually. They are two types of diabetes. Type 1 diabetes is characterized by the immune complex mediated attack on insulin produced by B cells in the pancreas, and type 2 diabetes arises due to inability of insulin to regulate glucose in the blood. The treatment previously used for diabetes was inadequate because it did not treat the causes of the disease. With the stem cells, scientists have greater chances of finding a better solution to treat the disease. This can be accomplished by using adult, Pancreatic, and embryonic stem cells to produce insulin secreting cells.

Stem cells, which have the ability to differentiate into insulin-producing cells (IPCs) either in vivo or in vitro, would provide a potentially unlimited source of islet cells for transplantation and alleviate the major limitations of availability and allogeneic rejection. Therefore, the utilization of stem cells is becoming the most promising therapy for

The focus of this paper is to critique research that uses cell therapy to manage diabetes or to possibly reverse the main cause of the disease. The discussed research, proposes that there are studies that strongly support cell therapy as the cure for diabetes is achievable. Although some of the research might not give precise definition for a possible cure, I plan to critique the given articles and give an opinion regarding the possibilities of the existence of a cure for diabetes.

The unique regenerative abilities of stem cells provide potential for treating diseases and many injuries, blood disorder, certain cancers such as Leukemia, and diseases such as diabetes and also heart diseases.

First are anti-apoptotic procedures, where all gene therapy research on diabetes will hopefully someday reach. These aim to prevent Type I Diabetes before it sets in and stop the

Stem cells has outgrown its medico-therapies in the field of bioengineering and also in the treatment of various conditions of the blood and immune system, or to cure specific cancers Since it’s a known fact that stem cells can different to specialized cells in an undifferentiated manner. As the paper states the use of insulin producing cells from human or rat adipose tissue –derived stem cells transduced with pancreatic duodenal homeobox can could cure type 1 diabetes. An alternative is, use of embryonic stem cells. Embryonic stem cells display the ability to differentiate in vitro into variety of cell lineages. Insulin-secreting cells are derived from the mouse embryonic stem cells which can normalize blood glucose when transplanted