Diabetes Is A Syndrome Of Impaired Metabolism Of Fat And Protein

Diabetes Mellitus is the metabolic disorder characterized by high levels of blood glucose that is caused by deficiency of production of insulin, action of insulin, or may be both of them. The uncontrollable output of hepatic glucose and reduced uptake of glucose by the skeletal muscle with reduced synthesis of glycogen lead to hyperglycaemia. Diabetes is a complicated disease; it can affect mostly every organ of our body and causes devastating consequences.

He said, diabetes mellitus is a chronic disease that occurs when the body doesn 't make enough of insulin, or the body doesn 't use insulin properly. Insulin is a key to regulation of blood glucose in our body. In types II diabetes a condition of when insulin insensitivity as a result of insulin resistance that decreases insulin production and eventual pancreatic beta-cell failure enough insulin to meet body needs. Impairment of beta- cell also can lead to problems with insulin production and resistance that can interfere with the process of glucose uptake in by cells and muscle. This condition leads to a decrease in glucose transport into the liver, muscle cells, and fat cells which can lead to a condition called hyperglycemia. Hyperglycemia occurs when there is a high level of blood glucose levels in our blood (Concepts Advisory Panel (2015) p.742).

This disease does not favor one gender over the other, it effects males and females equally. Currently, the origin of diabetes is a conundrum. Although, it is understood that the immune system attacks the beta cells but it is not clear how or why it occurs. It is hypothesized that T1D maybe hereditary and environmental factors contribute to the onset (5). Symptoms prevail in individuals whom have the majority of their beta cells destroyed via a cellular mediated autoimmune response (1).

Type 1 diabetes is a chronic autoimmune disorder, in which beta cells in the Islets of Langerhans are destroyed resulting in insulin deficiency and hyperglycemia. “The exact cause of why these normal cells are attacked by the immune system is a combination of genetic predisposition and certain viral infections such as the mumps and coxosackievirus which appear to trigger the destruction of pancreatic beta cells.” (Ignatavicius & Workman, 2013, p 1416) When these cells do not work properly, the body can no longer produce insulin. Insulin is a hormone that allows the body to use glucose that is found in foods for

Type 1 diabetes is usually a progressive autoimmune disease, in which the beta cells that produce insulin are slowly destroyed by the body's own immune system. It is unknown what first starts this cascade of immune events, but evidence suggests that both a genetic predisposition and environmental factors, such as a viral infection, are involved.

The organs involved include the liver, muscle, fat cells, liver, alpha and beta cells of the pancreas, GI tract, kidney, and brain. While the liver and muscle ideally increase glucose uptake in the fed state when insulin levels are high, with type 2 diabetes this is impaired. To further exacerbate the hyperglycemic condition, the liver not only fails to properly exhibit glucose uptake, but it actually over produces more glucose and thereby creates a cycle of glucose accumulation and further production. While this is occurring in the muscle and liver, fat cells have accelerated lipolysis. The lipolysis results in an increase in plasma free fatty acids (FFAs), which then in-turn impairs both first and second phase insulin secretion and can lead to excess fat deposition in the liver and muscle, contributing further to impaired insulin production. At the GI tract, gastric inhibitory polypeptide becomes resistant and loss of GLP-1 occurs. With impaired GLP-1, insulin resistance is again further enabled and hyperglycemia can become more profound. This occurs because glucagon suppression from the pancreatic alpha cells post meal does not occur as it would under normal circumstances, thereby enabling even more hepatic glucose production. While theories are not completely conclusive, insulin resistance in the hypothalamus may contribute to excess intake thereby contributing to additional glucose in the circulation. Finally, the kidney also plays a role in glucose dysregulation as it increases glucose reabsorption. All of these discussed mechanisms ultimately contribute to hyperglycemia and chronic hyperglycemia itself contributes to impaired beta cell function (DeFronzo,

The cause for type 1 diabetes is not well known but genes may play a role in this type of diabetes. Another suspicion for type 1 diabetes is the environment, for example a virus. A virus may cause the immune system to attack the cells on the pancreas because it detects a foreign organism. According to WebMD.com autoantibodies are present in almost all patients with type 1 diabetes.

Diabetes mellitus is a disorder characterized by abnormalities in carbohydrate, protein, and fat metabolism. The most common feature seen in diabetes is increased blood glucose levels. The main reason for this is either a decreased/ absent insulin production or resistance of the body to the action of insulin or both.

Diabetes mellitus is most commonly known as diabetes. Diabetes is formally a Greek word that translates to, “the making of lots of urine with sugar in it or making sweet urine” Brawley. This disease is due to a metabolic dysfunction. Diabetes is caused due to the fact that insufficient insulin is being produced in the pancreas. Sometimes this disease can even be caused because the cells are not being responsive to the insulin being produced. Unfortunately diabetes is not just one single strand but it comes in Type 1, Type 2 and gestational diabetes. To begin with, diabetes is not specified to just one group age or gender it can strike anyone from any age in life. According to the distinguished, What is Diabetes?, article, in the past years the amount of diabetes cases has increased dramatically by 50 percent making it be 29 million people suffering from this disease.

Diabetes mellitus is a metabolic disorder characterized by increased blood glucose concentration and disordered insulin metabolism. People who have diabetes are unable to produce sufficient insulin or use insulin effectively. In someone without diabetes, insulin secretions rise after food is ingested. This insulin allows muscle and adipose cells to take up newly absorbed glucose from the blood. Insulin is

In a person with Type 2 Diabetes the body may not produce enough insulin or the insulin produced may not work as effectively as it should. This is referred to as insulin resistance. Being overweight increases insulin resistance.

Patients with type 1 diabetes are believed to have acquired it through genetic disposition or an autoimmune abnormality caused by an environmental trigger. Essentially, the body’s pancreatic beta cells are destroyed, which in turn, inhibits the pancreas from either producing or secreting insulin. This caused a disarraying effect to all body systems. The cause of type 2 diabetes is said to be from an “imbalance between insulin sensitivity and insulin secretion” (Ralph A. DeFronzo). The pancreas is not producing adequate levels of insulin, seizing production of insulin or the insulin that is produced isn’t being used well (Kullman, 2006, p.146). This is an issue because sugar stays sedentary in the

An organ called the pancreas makes insulin. The role of insulin is to move glucose from the bloodstream into muscle, fat, and liver cells, where it can be used as fuel.

Type 1 Diabetes Mellitus (T1DM) is a disease caused by the inability of the body to produce insulin. As a result of the human defenses against autoimmune disorders, insulin-producing cells in the body are identified as foreign and therefore targeted by immune cells for destruction. Insulin is a hormone produced by the pancreas, which is responsible for regulating blood glucose levels through the regulation of glucose uptake from blood into storage cells. High levels of blood

Type I Diabetes Mellitus formerly known as insulin-dependent diabetes, is a metabolic disorder characterized by hyperglycemia resulting from lack of insulin. Type I diabetes mellitus results when pancreatic beta cells are destroyed because the beta cells of the pancreas have been damaged or destroyed by an autoimmune process. Type I diabetes mellitus is an absolute deficiency of insulin. If insulin is not given, fats are metabolized for energy, causing ketonemia acidosis. Research shows that it may be genetic. (Lippincott, Williams & Wilkins, p. 286)