Diabetes Is The Most Common Form Of Diabetes

The American Diabetes Association (2004) defines diabetes as a subset of metabolic diseases associated with hyperglycemia secondary to insulin failing to release, act, or both. Complications related to chronic diabetes can be detrimental to one’s health including but not limited to: heart disease, stroke, kidney disease, amputations, blindness, and other optical diseases. Furthermore, the prevalence of diabetes is rising at an astronomical rate within the United States as well as internationally. According to the Center for Disease Control and Prevention (CDC) (2016) an estimated 29 million people suffer with diabetes and 86 million are prediabetic within the United States (US). Without major interventions from the healthcare community,

Type-2 diabetes is a major, non-communicable disease with increasing numbers around the world. Type-2 diabetes occurs when the body cannot make enough insulin or the body is unable to consume the insulin that is produced. When type 2 diabetes is not properly managed, it can cause numerous health issues, including heart disease, stroke, kidney disease, blindness, nerve damage, leg and foot amputations, and sometimes death. Minor changes in a person’s lifestyle can reduce the risk of the onset of type-2 diabetes or can decrease the risk of co-morbidities that accompany this disease (Asif, 2014).

Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while

Type 2 diabetes is a polygenic, complex disease that has become a worldwide health crisis. According to the World Health Organization over 422 million people in the world had this disease in 2014 (1), the Center for Disease Control and Prevention stated that in the United States alone 29 million people had diabetes in 2014 (2). While the genetic predisposition contributing to the diabetes phenotype is not fully understood to date it still remains an area of active research. There are also various environmental factors that contribute stress to the glucose homeostasis system that provide a different approach in understanding this disease. Comprehending the pathogenesis of the disease has been an area of constant research for decades. There is hope that pharmaceutical developments can follow along and find medical treatments that can target the key pathogenic elements of this disease.

Type-2 Diabetes mellitus (T2DM) is a common disease worldwide. According to the American Diabetes association (ADA), 1808 million people in the United States have been diagnosed with diabetes, and another 7 million are thought to have the disease but have not been diagnosed. (Hilaire, Woods, 2013). This disease has impacted everyone in some way. It is a controllable disease; however many individuals choose not to control it or are uneducated on how to control it. Many people with type 2 diabetes (T2DM) also have hypertension, high cholesterol, obesity, lack of physical activity, poorly controlled blood sugars, and smoking. “Current evidence supports the concept that hyperglycemia significantly contributes to the development of both cardiovascular and microvascular complications of T2DM” (Chittari, McTernan, 2011). Cardiovascular disease (CVD) remains the leading cause of death in patients with diabetes mellitus, accounting for 50% of all deaths (Campbell & Hillman, 2010).

Diabetes has become a widespread epidemic, primarily because of the increasing prevalence and incidence of type 2 diabetes. Diabetes is an endocrine disease in which the body has either a shortage of insulin or a decrease ability to use insulin or both. Insulin is a hormone that allows glucose to enter the cells and be converted into energy. Diabetes can be characterized as a prevailing, incapacitating, and deadly disease. There are a number of risk factors that increase a person’s tendency toward developing type II diabetes. Modifiable risk factors include obesity, physical inactivity and poor dietary habits are just a few. The

Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes in the U.S., and it is a severe disease with numerous life-threatening consequences. T2DM occurs when insulin, which is a hormone released by the pancreas for sugar metabolism, becomes low or cannot be utilized by cells. In the normal condition, insulin circulates in the bloodstream and enables to convert starch, sugar, and all polysaccharides complex into glucose, which cells use for energy; however, in T2DM, there is continuously too much glucose in the bloodstream. When cells don’t interact appropriately with insulin, blood sugar increases, and this phenomenon is called insulin resistance that leads to many health problems,

Diabetes mellitus type 2, also know as type 2 Diabetes or noninsulin dependent diabetes, is a disease that effects the body systemically. Type 2 diabetes is a disorder in which cells become resistant to insulin and can no longer bind it properly to reduce blood sugar. The result of this is elevated glucose levels in the circulating blood that leads to endothelial injury in all regions of the body. Primary damages occur in the kidneys, cardiovascular, and digestive systems. According to “Annual Number of New Cases of Diagnosed Diabetes Among Adults” (2015), the overall incidence of type 2 diabetes was approximately 1.4 million new cases. From previous years this number has decreased; however, it can be further lowered with proper education, change in the Western diet, and increase in physical activity. In 2012 approximately 27.7 million Americans were living with Type 2 diabetes. The cumulative cost of care for American diabetes patients was 245 billion dollars, which encompasses medical treatment cost and the patients’ inability to work, ultimately resulting in decreased personal production (“Statistics About Diabetes”, n.d.). As exemplified by the National Institutes for Health (2015), “Diabetes is a lifelong disease and there is no cure.” Even though no cure is present, lifestyle modifications such as diet and exercise, play a role in self-regulation of blood glucose levels.

If not corrected by the year 2050, 1 in 3 Americans will have diabetes. The cost on the medical system to prevent and treat this population by 2007 was reported to be as high as $218 billion. It is imperative to continue research to prevent current state of disease for some but also to prevent secondary medical complications, which can include other organs and disease (Fonseca et al.,

Diabetes type 2 is a well-known disorder in America. It’s becoming one of the leading causes of premature morbidity and death worldwide. At Florida Hospital Diabetes and Translational Research Institute, Pratley (2013) stated that the prevalence of diabetes will continue to grow. It’s been estimated that by 2030 approximately 552 million adults will be affected mostly due to the growing of diabetes in developing countries. In the US alone, the number of people suffering from diabetes has drastically increased in the last 20 years because of the population being overweight or obese (Pratley, 2013). Those who are older in age, obese, have a family history of diabetes and lack of exercise have a higher chance of having it. The sooner people find

“Worldwide, more than 284 million people have diabetes, and this number is expected to reach 439 million by 2030” (Liebl, Khunti, Orozco-Beltran and Yale, 2015, p. 13). There are several types of diabetes present throughout the population (type 1 diabetes, type 2 diabetes, and gestational diabetes) (Mayo Foundation for Medical Education and Research [MFMER], 2016). “Type 2 diabetes, once known as adult-onset or noninsulin-dependent diabetes, is a chronic condition that affects the way your body metabolizes sugar (glucose), your body 's important source of fuel” (MFMER, 2016). There is a debate about whether or not Type 2 diabetics would benefit from insulin sooner (Liebl, Khunti, Orozco-Beltran and Yale, 2015). When considering diabetes management there are several things to consider, for instance the cost of medication regimens, diabetes complications, and education on self-management (Liebl, Khunti, Orozco-Beltran and Yale, 2015).

Diabetes is an insidious as well as a debilitating metabolic disease with variety of causes. (Bolajoko Idiat Ogunyinka ) Diabetes comes in two forms, type one and type two. Both types are manageable with different types of treatments and lifestyle changes. Many people live for years undiagnosed. “Diabetes remains the 7th leading cause of death in the United States in 2010.” (National Diabetes Statistics) Unfortunately, a cure for diabetes remains undiscovered.

Diabetes is an endocrine disorder characterized by elevated glucose due to insulin resistance or deficiency. About 29.1 million people in America are reported to have diabetes with the highest prevalence occurring in men; about 25.9% of adults 65 years and older have diabetes.1 Type 2 diabetes (T2DM) is the most common type of diabetes, often due to insulin resistance. Metformin is the treatment of choice in patients with T2DM, a second agent such as a sulfonylurea is added to metformin in patients who are not at goal or unable to tolerate metformin therapy. According to the American Diabetes Association (ADA) guidelines, the choice of a second agent should be based on a patient-centered approach to include efficacy, safety, the effect on

Diabetes is a common chronic disease that causes problems in the way the blood uses food. The inability of the body to transform the sugar into energy is called diabetes. Glucose, a simple sugar, is the primary source of fuel for our bodies. When food is digested, some of the food will be converted into glucose which is then transferred from the blood into the cells however, insulin, which is produced by beta cells in the pancreas is needed. In individuals with diabetes, this process is impaired.

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.