Diabetes Mellitus, Burden And Trends

You will be given oral medications to reduce the glucose level in the body. Insulin will be needed for type 1 diabetes and this will be taken for life. Insulin is also used in type 2 diabetes along with oral medicines.

Why do we treat diabetes? There are a number of downstream events associated with abnormal blood glucose levels. If glucose levels are managed properly, the complications associated diabetes can be controlled, and sometimes completely prevented. The main problem with having more than the normal amount of glucose circulating in the blood stream is the effect that excess glucose can have on both large and small blood vessels (DTC, 2004). Micro-vascular and macro-vascular problems associated with diabetes can be seen in the heart, eyes, kidney, legs and feet. Diabetic patients are twice as likely to suffer from a mycocardial infaraction, twenty-five times more likely to suffer blindness, and seventeen times more likely to suffer kidney failure compared to a non-diabetic (DTC, 2004). Because of great number of risks associated with abnormal blood glucose levels, diabetes is aggressively treated to improve the quality of life and prevent complications in patients.

The prevalence of diabetes mellitus, type 2 (DM II) is grossly affecting people worldwide. 24 million individuals in the United States were diagnosed with DM II in 2011 (Hunt, C. W., Grant, J. S., & Appel, S. J., 2011). 109.6 million DM II cases were reported in China in 2015, with an expected 36% increase by 2040 (Browning, C., Chapman, A., Yang, H., Liu, S., Zhang, T., Enticott, J. C., & Thomas, S. A., 2016). The incidence of DM II is also expected to increase by 190% in Omani people over the next 20 years (D’Souza, M. S., Karkada, S. N., Venkatesaperumal R., & Natarajan J., 2015).

Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.

Answer: The combination of Insulin as well as oral hyperglycaemic drugs may be prescribed for Diabetes because they help in lowering the blood glucose levels. However the primary treatment doesn’t consist of these drugs. The primary treatment comprises of Diet control, Physical activity and Weight control. If after following the primary treatment strictly, no improvement in the blood glucose level is achieved then medication is suggested for the same. Insulin helps in maintaining the blood sugar levels. Note that insulin is not to be taken orally because the acids and digestive juices in the stomach destroy it. It has to be injected under the skin only. Taking insulin leads patient to experience Hyperglycaemic condition. The Hyperglycaemic drugs helps our body to react appropriately with the insulin so that the insulin hormone is able to help transfer glucose from blood to the cells successfully.

Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while

Type 2 diabetes can be controlled through healthy diet and regular exercise. However some people with type 2 diabetes are prescribed tablets to control their blood glucose levels. These tablets are intended to be used in conjunction with healthy eating and regular exercise. Eventually it may be necessary for diabetic patients to start taking insulin to control blood glucose levels, when your body is no longer producing enough insulin of its own.

Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group, Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med. 2008 Oct 2;359(14):1464-76. Epub 2008 Sep 8.

Diabetes is associated with an increased risk of developing primarily vascular complications that contribute to morbidity and mortality of diabetic patients. Poor glycaemic control leads to vascular complications that affect large (macrovascular), small (microvascular) vessels or both. Macrovascular complications include coronary heart disease, peripheral vascular disease and stroke. Microvascular complications contribute to diabetic neuropathy (nerve damage), nephropathy (kidney disease) and retinopathy (eye disease).

Strict glycemic control in T2DM can prevent the onset and progression of complications [4]. Despite of numerous interventions to improve adherence to the recommended standards

Overweight people are at a higher risk to develop type 2 diabetes. Due to this, it is important for you to maintain a normal weight and make sure that you do not go overboard your body mass index. If you are having difficulty in managing your weight, it is best for you to consult your doctor and ask for some safe recommendations to lose weight. • Taking of prescribed medications. Medications are needed to help control and treat the disease.

T2DM is often managed with strict glycaemic control. Glycaemic control is a way of maintaining euglycemic blood glucose levels through a balance of both biological and psychosocial factors, including diet, exercise, supplements and medication.7 Once a patient has been diagnosed with T2DM their doctor will put them on a strict diet and exercise regime, this alone can sometimes be an effective method of glycaemic control for patients.

Lo C, Toyama T, Hirakawa Y, Jun M, Cass A, Hawley C, Pilemore H, Badev SV, Percovic V, Zoungas S. Insuline & Glucose lowering agents for treating people with diabetics and chronic Kidney disease. Cochrane Database of systematic reviews 2015, Issue 8. Art. No. CD011798. DOI:10.1002/14651858.CD011798.

     Present treatments for type one diabetes require lifelong care in order to keep blood sugar levels within a safe range. Some treatments include monitoring blood levels several times a day using a home blood sugar meter, taking several insulin injections everyday or using an insulin pump, eating a balanced diet that spreads carbohydrates (sugars) throughout the day to prevent high sugar levels after meals, regular medical checkups to monitor and adjust treatments as needed.

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.