Diabetes Mellitus

Diabetes is a disease where the body is unable to produce or use insulin effectively. Insulin is needed for proper storage and use of carbohydrates. Without it, blood sugar levels can become too high or too low, resulting in a diabetic emergency. It affects about 7.8% of the population. The incidence of diabetes is known to increase with age. It’s the leading cause of end-stage renal disease in the US, and is the primary cause of blindness and foot and leg amputation. It is known to cause neuropathy in up to 70% of diabetic patients. Individuals with diabetes are twice as likely to develop cardiovascular disease. There are two types of diabetes: Type 1 and Type 2.

Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas

Diabetes is a growing concern and health challenge for the American people (b). Diabetes is a condition in which the body cannot react to insulin appropriately or either cannot produce insulin efficiently (w). “Without a properly functioning insulin signaling system, blood glucose levels become elevated and other metabolic abnormalities occur, leading to the development of serious, disabling complications” (w). There are numerous forms of diabetes amongst the nation, however, there are three main forms of diabetes. Most people have heard of type one diabetes, type two diabetes, and gestational diabetes because they are common. Type two diabetes deals with a resistance to insulin, while

Diabetes is a disease that affects the body’s ability to produce or use insulin. It is a precursor to numerous other diseases, which can quickly deteriorate patient’s health if

Insulin resistance is the first physiological change occurring in type two diabetes. In these type two diabetic patients, insulin is unable to move glucose into liver, kidney and muscle cells although insulin is able to attach properly to the cell surface receptors. In order to rectify this, most patients with type two diabetes start secreting normal to very high levels of insulin, which can initially overcome this resistance. After a while, the pancreas cannot keep up with this high insulin production and the cells become resistant to glucose intake. Persistent hyperglycemia or high blood glucose levels are not desirable since this causes damage to the beta cells of the pancreas that produces the insulin hormone. This damage to beta cells further hampers insulin synthesis and patients at this stage are categorized as full-blown diabetic. Such patients consistently show a hyperglycemia state even after hours of fasting ( Hinkle & Cheever,

Diabetes Mellitus (DM) or Type 2 Diabetes is seen as a metabolic disease that is categorized by abnormally high blood glucose or hyperglycemia. Diabetes Mellitus is also formerly known as noninsulin-dependent diabetes mellitus and is the most common form of diabetes that is seen. Insulin is a hormone that is supplied to the body that allows us to efficiently use glucose as fuel. When carbohydrates are broken down into sugars in the stomach glucose enters the blood circulation simulating the pancreas to release insulin in an appropriate amount to become used for energy. With diabetes mellitus the body does not properly make use of the insulin supplied for the body. This causes the pancreas to produced an extra amount if insulin which the body cannot keep up with, causing an imbalance to the blood glucose levels (American Diabetes Association, 2015). In the united states diabetes affects almost 29.1 million people, while the another 86 million people have pre-diabetes but do not know. It is also known as the 7th leading cause of death in the country in the recent years (MedicineNet.com, 2016). For a patient suffering from a chronic form of diabetes mellitus understanding how these mechanisms lead to the condition can be used as preventative measures. Potential consequences as well as the causes and clinical manifestations will ensure a better knowledge on the issue to monitor the condition.

Diabetes remains the 7th leading cause of death in the United States. The cost of care for diabetics and new cases of diagnosed diabetes patient’s rise more and more each year. In 2010 234’051 death certificates were issued with the mention of diabetes as a contributing factor to the death. About 60% of lower limb amputations were performed. The cost of care for diabetics is now at an astronomical high of $176 billion dollars. A change a most be made to prevent all of this loss. (American Diabetes Association, 2014)

Type 1 diabetes is a serious chronic condition that tends to arise prior to adulthood. The disease requires substantial lifestyle changes in order to cope, and can lead to several debilitating outcomes if left unchecked. According to the American Diabetes Association ([ADA], 2017), Type 1 diabetes is defined as a chronic condition where the body no longer produces the insulin hormone, and is therefore unable to utilize and store glucose. As a result, individuals with Type 1 diabetes may experience excessively high or low blood glucose levels: hyperglycemia and hypoglycemia respectively (ADA, 2017). Both sides of the spectrum can have devastating effects on the body’s cardiovascular and renal activities, in addition to deteriorating the peripheral

Diabetes continues to be a growing problem for the United States population especially type 2 diabetes, which “accounts for about 90% to 95% of all diagnosed cases of diabetes”(Center for Disease Control and Prevention (CDC), 2014). Type 2 diabetes, formally known as adult onset diabetes, is defined as a “disorder of insulin resistance in which the cells primarily within the muscle, liver, and fat tissue do not use insulin properly. As the need for insulin rises the cells in the pancreas gradually lose the ability to produce enough hormone”(CDC, 2014). Diabetes as a whole affects about “9.3% of the US population or 29.1 million people” (American Diabetes Association (ADA), 2014; CDC, 2014). Despite the high prevalence of the disease, it is only going to continue to grow if nothing is done to correct the problem. The “United States spent an estimated $245 billion on diabetes in 2012” (ADA, 2014; CDC, 2014). This outrageous number and the drastic impact diabetes has on health should emphasis the need to reduce the diabetic population in the future.

Diabetes (Diabetes Mellitus) is an unremitting disease where in the glucose in the blood is too high. Blood glucose level, or commonly known as the ‘blood sugar level’, are normally regulated by the hormone insulin that is made by the pancreas. Diabetes takes place when a problem in the hormone happens and how the body works. There are different types of diabetes – Type 1, Type 2, Impaired Glucose Metabolism, Gestational Diabetes and the Secondary Diabetes, but the two main

It is not news to anyone that one of the most known disease in the world is diabetes mellitus, people with type two diabetes produces some insulin, but not enough to keep their blood sugar at a normal level, however the one that are affected by the type 1 diabetes or childhood-onset type 1 DM do not produce insulin at all. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. (ADA, 2015) . That circumstance puts them at greater risk for heart disease, renal disease and blindness to name a few. Sadly Worldwide, the occurrence of type 1 DM has been steadily rising, representing a significant burden on the people and to the health-care systems. Although momentous improvements in the care of T1DM patients, a subsection remain in major difficulty due to stubborn hypoglycemia. The possibility of IT offers the chance of better glycemic mechanism. Currently we are observing considerable advancement in the number and results of IT phenomenal. In type 1 DM is an autoimmune disease that causes the body the destruct the b cells in the pancreas, which are responsible for the production of insulin. As a result, supplementation of insulin is a must in the management of the disease through meticulous care of multiple daily injections to control blood glucose. Even accommodating to the treatment many do not maintain a stable blood glucose level and are at risk for metabolic problems. Ultimately replacing of β cells are the only

Diabetes Mellitus is a disease of the endocrine system primarily differentiated between type 1 and type 2. Type 1 diabetes occurs when the pancreas is unable to produce insulin and was previously seen in the younger generation which is no longer the case.1 Type 2 diabetes is the more prevalent of the two types and involves elevated blood sugar levels due to the insufficient production of insulin. Risk factors that make an individual higher risk for type 2 diabetes include increasing age, obesity, family history, a sedentary lifestyle.1,2 Innovative drug therapies for type 2 diabetes remain important for the treatment and reduction of the disease.

Diabetes is a metabolic disorder in which energy cannot be obtained from the body through normal mechanisms of action. Insulin is required to assist in moving glucose across cell membranes. There are two types of diabetes. Type one, which is characterized by the pancreas no longer having the ability to make insulin, and Type two, which is characterized by the resistance of the tissue receptors of the body to insulin. Diabetes is sometimes called “The Silent Killer,” as it has significant rates of illness and mortality. There is a large correlation between diabetes and cardiovascular disease, end-stage renal disease, amputations, and blindness (Gulanick, Myers 2014).

Type 2 diabetes is one of the most common chronic metabolic disorders with higher rate of fatal chronic condition, morbidity and mortality. It is characterized by poor glycemic control due to decreased insulin sensitivity(1,2).According to the report of International diabetes federation (IDF) in 2015,415 million people have suffering from the disease worldwide and the rate will be increase to 642million in 2040(3).

Diabetes is a systemic disease caused by a decrease in the secretion of insulin or reduced sensitivity or responsiveness to insulin by target tissue. (Beale, et al., 2011) The incidence of diabetes is growing rapidly in the United States and worldwide. An estimated 347 million people around the world are afflicted with diabetes. (Whalen, et al., 2012) According to World Health Organization (WHO), Diabetes prevalence among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014. It is the major cause of blindness, kidney failure, heart attack, stroke and limbic amputation. World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030. It is a complex and costly disease that can affect nearly every organ in the body and result in devastating consequences. The leading cause of non-traumatic lower extremity amputations, renal failure, and blindness in working-age adults, diabetes is also a major cause of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations, perinatal mortality, and disability. (Cefalu, 2000) Insulin therapy and oral hypoglycemic agents have demonstrated improvement in glycaemic control. However, Insulin therapy has some disadvantages such as ineffectiveness following oral administration, short shelf life, of the need for constant refrigeration, and fatal hypoglycaemia, in the event of excess dosage.