Diabetic Neuropathy

Explain, that diabetes is the most common cause of neuropathy. Peripheral neuropathy is the most common form of diabetic neuropathy. Your feet and legs are often affected first, followed by your hands and arms.

Most patients who have diabetes for an extended amount of time may end up with diabetic neuropathy, which is damage caused to the nerves; it affects the peripheral nerves, autonomic nerves, and focal nerves. From the high blood sugar, it can destroy parts of the patient’s blood vessels, heart, and kidneys. If diabetes is not treated, it will almost always cause heart disease or kidney disease.

7. Examine your feet. Diabetes-related nerve damage can mean that you might have minor injuries to your feet that you can’t feel. This can lead to infections and other complications. Check the soles of your feet daily. Put lotion on them at night to keep the skin in good condition. Wear comfortable shoes that fit correctly. Ask your doctor to examine your feet whenever you have an office visit.

Importantly, in any patients with neuropathy and specifically patients with a severe form,it is essential to rule out any other causes apart from diabetes such as ,drug induced neuropathy (e.g. isoniazid) , alcohol abuse, nutritional deficiency like vitamin B12 deficiency(Wile DJ,et al 2010),vasculitis , inherited neuropathies, and renal disease (Freeman R.2009)

Other factors include high rates of impaired vision, including poor low-contrast visual acuity and poor depth perception, lower limb amputations, vitamin D deficiency, and impaired renal function. Other factors include dementia, urinary incontinence, depressive symptoms, and mild cognitive impairment. As well a high consumption of medications, poorer walking performance, and reduced cognitive function, are mediators of falls in diabetics. Since peripheral neuropathy is seen in most diabetic client this may exhibit greater postural sway in standing or a slower than average

Nerve damage from diabetes is called diabetic neuropathy. About half of all people with diabetes have some form of nerve damage. It is more common in those who have had the disease for a number of years and can lead to many kinds of problems.If you keep your blood glucose levels on target, you may help prevent or delay nerve damage. If you already have nerve damage, this will help prevent or delay further damage (ADA,2016). I've encountered patients that describe the feeling as pins and needles, and that their feet are constantly cold. There isn't medication to cure the nerve damage that causes neuropathy, however certain mediction can be precribed by your physician that will help with the symptoms. Increased blood glucose levels damages blood

Peripheral neuropathy involves damage to the peripheral nervous system which serves as a major communication network for the brain, the spinal cord other parts of the body. Peripheral nerves are responsible for sending sensory information such as “cold feet” back to the brain. It is also responsible for sending signals from the brain and spinal cord to the muscles to elicit movement. There are more than 100 types of peripheral neuropathy and each is classified based on the type of damage on the nerve. Some peripheral neuropathies are due to damage to the myelin sheath which is the fatty protein that coats and insulate the axon. This myelin sheath is important for increasing the speed at which impulses propagate down a myelinated nerve fiber.

Diabetic neuropathy is nerve damage that occurs with diabetes. Approximately half of all people with diabetes have some form of neuropathy. It is more common in people who have had the disease for many years. Tight control of blood sugar can prevent neuropathy from occurring. Those who already have diabetic neuropathy can stop it and prevent it from becoming worse with healthier eating habits, medications and exercise.

While there are a variety of medical conditions which go hand in hand with peripheral neuropathy, diabetes is the most common. When nerves which transmit pain and other signals to the brain are damaged due to regularly high blood sugar levels, diabetic neuropathy can occur.

The pain Giovanni feels when ambulating and the tingling in his peripheries are an important sign of diabetic neuropathy (Carlson & Castro 2016). Over time, diabetes can cause damage to the nerves in the body. This is more common in patients who

Hyperglycemia is known to adversely affect peripheral nerve structure and function in younger (3–6 months) but not in older rats. Physical and functional damage to peripheral nerves associated with diabetes is related to increased activity of the polyol pathway . The polyol pathway is a minor pathway of glucose metabolism that increases the intracellular content of the polyol sorbitol in response to increased extracellular glucose concentrations.

I have heard many people complaining about feeling pain in some part of the body. This makes me ask the question, what are the causes of neuropathy? Nobody loves being tormented with numbness, intense stabbing pains among others.

A peripheral neuropathy is an injury to the peripheral nerves which can result in pains and weakness of the hands and feet. A peripheral neuropathy can be caused by a traumatic injury or an infection. Symptoms and sings for a peripheral neuropathy depend on the types of nerves that are affected including: sensory, motor and autonomic nerves. The signs and symptoms of these three types of nerves are: pains as burning in the hands, arms, feet or legs, weak muscles, falling down, dizziness and digestion problems etc… There are a lot of reasons why a person will have a peripheral neuropathy including alcohol, infection, diabetes, medications, inherited and taking poisons. Moreover, it’s safer to see a specialist in

Nerve: In the control group, sections of the nerve showed myelin sheaths wrapping around the axons which were centrally placed. The nuclei of the Schwan cells are elongated and oriented longitudinally. The transverse sections of the nerve showed the bundles of the axons covered by the perineurium. In the diabetic group, there was splitting of the axon bundles and wide interruptions in the nerve fibers. Increased connective tissue proliferation was seen with a loss of perineurium. Edema was seen in the endoneurium leading to a disruption of nerve fibers. There was an infiltration with macrophages. Marked axonal degeneration was seen along with demyelination. Following treatment with 400 mg/kg of fenugreek + 250 mg/kg of metformin, Section of the nerve showed normal structure similar to that of the control group.

“Diabetic neuropathy begins as a generalized asymptomatic dysfunction of sensorimotor or autonomic peripheral nerve fibers and is by far the