Diagnosis Of Hepatitis B Virus

1267 WordsMay 2, 20176 Pages
Diagnosis of hepatitis B virus: Patients with CHB should have full history and physical examination with special consideration on risk factors for coinfection, alcohol use and family history of HBV infection and liver cancer (AASLD, 2016). (i) Hepatitis B core antigen There are different types of antibodies which reflect several stages of immune response. HBc Ag can stimulate production of antibodies from two classes, known as immunoglobulin "M" (IgM) and immunoglobulin "G" (IgG): • IgM antibodies directed against HBcAg, which indicating HBV infection within the last six months. • IgG antibodies directed against HBcAg, which indicating HBV infection more than six months. • Patients with CHB tend to be positive for HBsAg…show more content…
Increases in alanine aminotransferase levels are particularly marked during acute infection, although even in chronic hepatitis, alanine aminotransferase levels are commonly two or three times higher than the upper limit of normal (Ryder and Beckingham, 2001). Patients infected with the HBeAg-negative mutant strain of HBV are particularly prone to flares in alanine aminotransferase levels (Bonino and Brunetto, 2003). The levels of other liver enzymes can also increase as the immune system damages hepatocytes. As a result, clinicians measure levels of several enzymes in a series of ‘liver function tests’. In many cases, patients do not develop symptoms of hepatitis despite showing markedly elevated liver enzymes. There can be a number of causes of elevated liver enzymes, such as herbal remedies, alcohol or other drugs, but they are usually a good surrogate for active liver disease (Ryder and Beckingham, 2001). (v) HBV DNA levels The most accurate and sensitive way to assess the number of viral particles (the viral load) within the body is to directly measure levels of HBV DNA within the blood (Ganem

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