Difference Between A Pharmaceutical And A Biologic

2463 Words Apr 8th, 2015 10 Pages
UNIVERSITY OF QUEENSLAND
SCHOOL OF CHEMISTRY AND MOLECULAR BIOSCIENCES
BIOT7018 BIOLOGICS
Assignment 1 – (Weeks 1, 2, 3 & 4)

SECTION A Subjective Questions associated with Lecture Material

1. What is the difference between a pharmaceutical and a biologic? 2.5 marks
Pharmaceuticals are small molecules manufactured in machines, while biologics are big molecules made in living cells.
Pharmaceutical copies are called generics while for biologics the term is a biosimilar. Why is the naming different for biologics? 2.5 marks
The biosimilar can not be called generic because are not clinically interchangeable. The biosimilar do not have the same chemical active ingredient of the novel product as the generic drug. In comparison with a generic, the biosimilar to be approved needs to be have clinical and preclinical studies while the generic do not require this studies but pharmacokinetics tests.

2. What are the broad strategies for therapy using biologic medicines? 5 marks
Some of the strategies used in biologic medicines are:
• Inhibit the over expression of mediators of disease.
• Supplement growth factor, hormone or cytokine deficiencies, which can enhance immune response through receptors and the signal transduction cascades subsequently.
• Enzyme replacement therapy for the treatment of lysosomal storage diseases
• Target tumour binding for drug delivery and tumor cell death.
• Decreasing the activity of the immune system using immune-modulators to reduce inflammation.

3.…
Open Document