Different Types Of Hemophili Blood Clotting

Hemophilia is a rare blood condition in which an individual’s blood cannot clot appropriately to stop bleeding. There are two types of Hemophilia, Hemophilia A and Hemophilia B. This paper will be focusing on Hemophilia A, also known as classic hemophilia. “Hemophilia A is a genetic disorder caused by a missing or defective factor VIII, a clotting protein” (National Hemophilia Foundation, n.d., para. 1). Clotting proteins work with cell fragments called platelets to stop bleeding. “When blood vessels are injured, clotting factors help platelets stick together to plug cuts and breaks on the vessels and stop bleeding (National Heart, Lung, and Blood Institute, 2013, para.

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

He cut his small toe when he was one year old. There was unusual bleeding. He was given a blood transfusion at a local hospital. He started bleeding frequently from different sites such as, his gums, nose and ears. At the age of four, he bled from his forehead and hip after a fall. He was tested at Christian Medical College Hospital, Vellore and he was diagnosed as having Type ‘A’ Hemophilia with severity at less than 1 %.

Hemophilia : Normally the blood clots in a few seconds, but in Hemophilia which is a rare disorder the blood does not clot normally as it is deficient in blood clotting proteins also called the clotting factors.So in any case if you are suffering from Hemophilia then the blood will take a much longer time to clot than normal .Small injuries are not much of a worry but its of greater concern if there is any internal bleeding which may cause a severe damage to internal organs.

Hemophilia B is a variation of the disease in which the genetic disorder is caused by a missing or defective factor IX, another clotting protein (Hemophilia B). Although it is passed down from parents to children, about 1/3 of the cases are caused by a spontaneous mutation (Hemophilia B). Hemophilia C is another variation of the disease in which the mutation causes a deficiency in factor XI (What Is Factor XI Deficiency?). Hemophilia C differs from Hemophilia A or B in that there is no bleeding into the joints and the muscles (What Is Factor XI Deficiency?). According to World Federation of Hemophilia, factor XI deficiency is the most common of the rare bleeding disorders and the second most common bleeding disorder affecting women (What Is Factor XI

Hemophilia is a medical condition in which the ability of the blood to clot is severely reduced, causing the sufferer to bleed severely form even a slight injury. This causes people to bleed for long periods of time, since

Hemophilia A is the most common clotting disorder which “…accounts for approximately 85% of… [Hemophilia cases].” (Copstead-Kirkhorn, 2012, pp. 304) The cause for this clotting disorder is the deficiency of clotting factor VIII. With this factor lacking, a patient can experience abnormal bleeding accompanied by a prolonged clotting time. This disorder is also classified as X-Linked recessive. Thus, if the father has Hemophilia A and the mother does not, there is a 50% chance that the sons will have the disorder and 50% chance that the daughters will be a carrier of the disorder. It only takes one infected X chromosome to spread

Hemophilia is a group of hereditary genetic disorders that affects the body’s ability to cause blood clotting which stops bleeding after a blood vessel is broken. According to Zerwekh, Miller, & Cliburn (2012) hemophilia is a rare condition with only about one instance in every 1000 births for hemophilia type A and one in every 50000 births for hemophilia type B. In total only around 18000 people are hemophilic in the United States of America. Every year in the U.S, around 400 babies are born with the disorder ("Home | Hemophilia | NCBDDD

There are symptoms of Hemophilia A and Hemophilia B. They are: Big Bruises, Bleeding into muscles and joints, Spontaneous bleeding (sudden bleeding inside the body for no clear reason), prolonged bleeding after getting a cut, removing a tooth (or having surgery), and also bleeding for a long time after an accident (especially after an injury to the head).

Hemophilia A, an X-linked genetic disease, is the most common coagulation disorder with an incidence of about 1-2 in 10,000 males and is caused by mutations in the factor VIII (FVIII) coagulation gene [PubMed1]. It causes infected individuals to not be able to coagulate their blood efficiently or at all when getting a cut or some injury in which blood is exposed. This disease can be very deadly because of major blood loss.

Normal mechanisms for blood clotting involve interactions between injured blood vessels, platelets, and over 20 different proteins that circulate the blood.

Bleeds can occur internally, into joints and muscles, or externally, from minor cuts or trauma. How frequently a person bleeds and the severity of those bleeds depends on how much FVIII is in the plasma, the straw-coloured fluid portion of blood. While living with haemophilia A is not life threatening it can greatly effect quality of life depending on the severity of the disease in the sufferer. The severity of the disease is determined by the levels of FVIII in the plasma, the straw-coloured fluid portion of blood. FVIII is a protein produced in liver sinusoidal and endothelial cells outside of the liver throughout the body, while the protein is not needed it circulates in the bloodstream in an inactive from until an injury that damages blood vessels occurs, at which point it flows to the point of injury and clots to stop the blood flow. Normal plasma levels of FVIII range from 50% to 150% [1]. Levels below 50%, or half of what is needed to form a clot, these plasma levels are the determining factor in discovering the severity and symptoms of haemophilia. Haemophilia A has three levels of severity, these are mild haemophilia (6% up to 49% of FVIII in the blood), bleeding will only occur after surgery or serious injury, moderate haemophilia (1% up to 5% of FVIII in the blood) [2], which will cause spontaneous bleeding episodes and continuous bleeding after

Human beings contain tens of thousands of genes that decide what characteristic will each person have from the color of their eyes to their risk of contracting various disease. Amazingly, one misplaced gene can change a person life forever. For instance,is a rare bleeding disorder in which the blood doesn't clot normally. Hemophilia is a genetic disease where there is a defect in the series of protein that forms blood clots. The series of proteins is called the coagulation cascade in which each factor activate each other in chain reaction. The last to to activate is factor 10a which in turn activates thrombin. Thrombin is an enzyme that converts fibrinogen to fibrin. The large amounts of fibrin then forms long strands and merges with platelets

A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.