Diffuse Intrinsic Glioma Thesis

Once a person has been diagnosed with brain cancer, treatment should begin immediately. Treatment for brain tumors involves any combination of surgery, radiation, and chemotherapy. Some tumors require several different surgical procedures; some can be treated with radiation alone. Surgery is the best process to remove a brain tumor. Surgery attempts to remove most, if not all of the tumor. Once most of the tumor is removed, the rest of the tumor can be removed through a process called radiotherapy.

Glioblastoma is the most common and aggressive form of malignant brain cancer in adults. On average, 8 of every 100,000 people in the U.S. are diagnosed with glioblastoma every year – representing approximately 2% of all cancers diagnosed [1]. Glioblastoma tumors form when astrocytes, star-shaped cells which support and protect the brain, re-enter the cell cycle and start to rapidly divide. Because the brain is supported by a large network of blood vessels, tumors grow quickly and are difficult to remove surgically. Present treatments for glioblastoma are limited to surgery, radiation therapy, and chemotherapy; however, despite these interventions tumors are likely to regrow. Consequently, typical survival time following glioblastoma diagnosis is less than 2 years.

Glioblastoma (pronounced like gleO blastoma) is an incurable brain cancer,Survival rate is usually measured in months.This became a word that was instantly defined, researched, dissected, feared, and tried to comprehend and understand by family,friends and acquaintances of Larry McKee (McKee)who was personally affected from this single word, it was quickly added to their vocabulary, because of the of the events that transpired on October 22, 2011 that forever changed lives “Glioblastomas are tumors that arise from the astrocytes- the star-shaped cells that make up the “glue-like,” or supportive tissue of the brain. These tumors are usually highly malignant (cancerous) because the cells reproduce quickly and they are supported by a large network of blood vessels.”(A.B.T A..) He was diagnosed with stage four.

Cancer is a word which evokes many different images and emotions. Nothing in this world can prepare a person for the utter devastation of finding out someone has been diagnosed with cancer, especially when this person is a child. Over the past twenty five years the amount of research and the survival rate for children suffering with cancer have increased dramatically. Despite these successes, the funding for new research necessary to keep these children alive and healthy is miniscule and too dependent on short term grants. Of the billions of dollars spent each year on cancer treatments and research less than a third is contributed to researching pediatric cancer. Given the media focus on adult cancers, research for pediatric cancer is

Specific Purpose: To convince the audience that childhood cancer is more common than believed, and that action should be taken to increase awareness and funding for research.

The American cancer society estimated that 18,500 people would be diagnosed with brain tumor and those 12,760 men and women would die of brain cancer in 2005.The National Cancer Institute (NCI) estimated that 22,070 new cases of brain and other central nervous system (CNS) cancers would be diagnosed in the United States in 2009. The American Brain Tumor Association (ABTA) clarifies this statistic further by estimating that 62,930 new cases of primary brain tumors would be diagnosed in 2010. By the year 2030, there will be 26 million new cases, and the death toll will reach to around 1.7 million people. According to World Health Organization (WHO), there are more than 120 types of brain tumors.

The main focus of this article is Richard Nares, a grieving father, who has become a hero in the eyes of many children fighting cancer. Nares has had a huge impact on two-year-old Sisi Johnson who has neuroblastoma. Sisi’s mother does not have a car and struggles to transport her daughter to and from chemotherapy as much as six times a week. Nares, who lost his son, Emilio, to cancer in 2000, has started a program called “Ride With Emilio”. This program provides transportation for low-income families with children battling cancer. The program has hundreds of patients who receive free rides to and from their cancer treatments. Nares met

Glioma is a tumor that is a type of brain cancer. Glioma tumors are made up by cells called glial cells. Glial cells normally provide nutrition, oxygen, and structural support to the brain. Three types of glial cells can produce tumors. Gliomas are named after the type of glial cell that is involved in the tumor. A tumor is formed when the glial cells grow into an abnormal mass of tissue. Gliomas are one of the most common types of brain tumors that occur in adults.

Every 3 minutes a child under the age of 15 is diagnosed with cancer worldwide. (150,000 p.a.) 1

The importance behind this health issue is that major advances in medicine haven’t significantly improved survivor rates nor have medical advances reduced the number of cancer cases per year in children under 18 years of age (Curtin, Minino, Anderson, 2016).“Congressman McCaul is a father of five and knows that every parent’s worst nightmare is their children receiving a life-threatening cancer diagnosis. Growing up, his childhood best friend lost his battle to cancer. It wasn’t fair then and it isn’t fair now. Congressman McCaul founded the Childhood Cancer

St. Jude is the only pediatric cancer research center that denies no child. It is a place where families do not have to pay for treatments and services that are not covered by insurance. It helped raise the overall survival rate of pediatric cancer from 20% to more than 70% (GuideStar, n.d.). Some of their goals are to continue to increase the cure rates for pediatric cancer in the United States; to reduce acute and long-term morbidity that are associated with pediatric cancer treatment; to lead the way in the prevention and control of pediatric cancer; and to advance research and treatment of pulmonary infectious diseases and non-malignant hematological diseases (GuideStar, n.d.). St. Jude is also the first National Cancer Institute-designated

Every year thousands of children, in the United States alone, are diagnosed with some form of cancer and more cases are occurring each year. When thinking about cancer we often associate it with adult cancers. Throughout the year there are certain days and months dedicated to supporting awareness of specific types of cancers that mainly occur in adults. Although there is some focus on childhood cancer, it does not get as much attention as with adult cancer, because of this there is also less focus on funding childhood cancer research. With a rise of pediatric cancer diagnoses, researchers should take advantage of the modern day technology available and focus some of the attention away from adult cancers and begin to put efforts into finding

Glioblastoma(GB) is the most common primary malignant solid brain tumor in adults1. Known for its aggressive characteristics and poor prognosis, the median survival rates of GB patients remain less than 18 months2,3. Tumor relapse owing to chemotherapeutic resistance is almost universal and GB is no exception, thus reflecting in high mortality and morbidity rates4. The WHO 2016 classification of brain tumors identifies GB tumors based on histology, molecular and genetic characterization into defined transcription profiles such as classical, neural, pro-neural and mesenchymal types5. Additionally, the commonly occurring genetic aberrations of primary GB are amplifications/mutations of EGFR, PDGFRA, PTEN, and of secondary GB are IDH1, MDM2

As established in the National Cancer Institute, “Cancer is the leading cause of death worldwide for children and adolescents in America, accounting for more than 91,250 children that lose their lives to this disease” (National Cancer Institute). Cancer is not considered a terminal illness, but more of a chronic illness because of the intense treatment that the individual has to endure. As a result of this treatment the chances of survival for children suffering from pediatric cancer has increased around 80 percent. The increment in the survival rate has made it possible for many parents to not have to go through the acceptance that they are about to lose their child to a terminal illness, but have coping strategies that will make them adapt to the fear of the reoccurrence of that illness. This illness has a great impact on the patient as well as the family because not only do they have to adapt to this illness physically, but also mentally. Research has shown that there are both short term and long term effects that come into effect when the child is both in treatment and also years after the treatment. The type of cancers that these adolescents have to endure range from leukemia, brain tumors and other cancerous tumors that have appeared in recent medical studies. These tumors can either be benignant, an acute case that is non-cancerous or malignant, a cancerous case that will need intense treatment over an extended period of time.While many would say there is more of a

Raising awareness is a step in the right direction to escalating advocacy and support for childhood cancer research (acco.org 1). One nationwide project that brings in the most financial aid for visitors and patients is St. Jude’s Children's Research Hospital (StJude.org 1). The mission of St. Jude is "to advance cures and the means of prevention, for pediatric catastrophic diseases through research and treatment" (StJude.org 1). That being said, the support "helps ensure that St. Jude Children’s Research Hospital will continue its lifesaving mission of finding cures and saving children” (StJudes.org 1). Few people realize the dire situation patients and families are in when they are deciding to not