Discovering Cancer Cells In Peripheral Blood Focusing On

1702 WordsMay 3, 20177 Pages
Discovering Cancer Cells in Peripheral Blood Focusing on Breast Cancer Taylor Mitchell Thomas University Abstract The discovery and use of tumor cells in pertinent to the development, diagnosis and treatment of cancer. This paper will show specific research not only about tumor cells but also about circulating tumor cells (CTC). It is important to understand how these cells are discovered and the recent development in finding them in peripheral blood in a minimal amount of time. The Chemistry, Pathology and Laboratory departments conduct a study on 90 specimens from 24 patients, all who have been diagnosed with breast cancer. Using flow cytometry, this article will go into detail about the usage and findings of CTCs.…show more content…
This also correlates to the response white blood cells have in peripheral blood (Jia et al., 2015). Tumor markers and cancers cells are both produced by cancer that is the tale tell sign for the appropriate diagnosis. Tumor markers can help detect, diagnose and treat certain kinds of cancer. Doctors will biopsy, measure and test tumors to discover whether or not it is malignant or benign (“Tumor Markers). Tumor markers can reveal the stage along with the prognosis of the patient. Tumor markers not the only sign that can be used to discover cancer in a patient. Circulating tumor cells is also a useful tool. It is defined by the CellSearch assay, that CTC is a cell that is “EpCAM positive, cytokeratin positive, CD45 negative, and nuclear stain positive (Zhao et al., 2013).” The Department of Chemistry, Laboratory and Pathology at the University of Washington in Seattle, WA conducted a study to increase the automated number of the counting method for CTCs in whole blood using their own recently developed ensemble-decision aliquot ranking or eDAR. While these cells were reported about 150 years ago, they have continued to be a useful tool in diagnosis cancer and its treatment (Zhao et al., 2013). These particular cells has been discovered in patients with different kinds of cancer (Zhao et al., 2013). Unfortunately, however, observation of these cells comes at a timely cost. Up until recently it took
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