Discovery Of Nonsteroidal Anti Inflammatory Drugs ( Nsaid )

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Salicylates are one of the oldest medications that are still used as analgesics and antipyretics, in addition to their anti-inflammatory and antiplatelet properties. Thus, salicylates are found in many oral and topical preparations, which increases the possibility of toxicity. Salicylate toxicity, also known as salicylism, occurs due to accidental or intentional acute ingestion of a salicylate-containing medication, or due to chronic medication use (Herres, Ryan, and Salzman, 2009). Around 100 years ago, salicylate-containing medications were used extensively as analgesics even among children, and they were also used topically for scabies and impetigo before antibiotic development. Salicylism incidences have declined recently due to the restriction of aspirin use among children in order to prevent Reye syndrome, the discovery of nonsteroidal anti-inflammatory drugs (NSAID), and development of antibiotics (Chyka et al., 2007). In 2014, over 24,700 cases with salicylate toxicity were reported, including 7411 single exposures to methyl salicylate (Mowry et al., 2015). Salicylism can be further defined according to the sources of exposure, toxic effects, symptoms, diagnosis, and treatment. Salicylism has several causes and sources of exposure. The most common cause is acute toxicity, which occurs as a result of accidental ingestion of salicylate-containing medications, or intentional suicidal attempts. Although single dose toxicity is rare, incorrect or high dosing of

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