Discussion Regarding Alli

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Obesity is a worldwide epidemic and serious chronic disease state that plagues all ages and races. Globally 1.7% of people are classified as obese, with body mass indexes (BMI) of 30 or higher (Sonnenberg, Matfin, & Reinhardt, 2007). According to Flegal, Carroll, Ogden, and Curtin (2010) 35% of men and 35.5% of women in the United States (U.S.) are obese. The prevalence of childhood obesity is steadily climbing each year with the ensuing repercussions of adult disease states now being diagnosed in children and teens (Ben-Sefer, Ben-Natan, & Ehrenfeld, 2010). Hence, the race for finding an answer to weight control has become a priority. The pharmaceutical giant GlaxoSmithKline (GSK) has supposedly offered one answer in the…show more content…
Although, upon further reflection generalizabiltiy cannot be exclusively established because GSK did not state the maximum age of their study sample, race, or gender, thus potentially making the inference of generalizability invalid. The only additional information that GSK provided regarding the sample was in reference to baseline BMIs, visceral fat percentages, and waist circumferences. The following questions should have been asked and answered. Were there any screening restrictions for participants? Within the context of the studies what is considered a low fat, reduced calorie diet? Did the participants exercise, if so was it aerobic or anaerobic, and how many minutes per week was each type of exercise performed? What were the ages of the sample, race, and gender? GSK’s description of the research findings does not mention what types of controls were used to minimize bias and maximize validity. The news release also did not allude to any limitations of the studies in regards to the small number of participants or that the studies were conducted over a very short period of time, with no long term findings on the efficacy of Alli. Unfortunately, GSK referenced only the poster presentations regarding the studies and not the original research articles. After a lengthy literature investigation the original research studies were located, revealing that the Visceral Fat Imaging
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