Dna Replication And Its Effect On The Development Of Mutations

1129 Words Feb 17th, 2016 5 Pages
Introduction:
DNA replication is one of the fundamental processes involved with the central dogma and is instrumental in the development of mutations, alternations and others changes that allow the process of evolution to operate and proceed leading to the biodiversity. In the process proposed by Watson and Crick (1953), the double helix unwinds to expose the bases in each strand of the DNA , where each of the two separate strands act as the template or molecular mould for the synthesis of a new molecule of DNA . As it is well known that the process of replication allows for the complementary base formation among the template strand and the newly synthesized DNA strand .this mechanism of complementary base pairing has resulted in the semi conservative mode of replication of the DNA molecule (Pray,2008).’
Stages of replication: The molecular mechanism of the process of replication is directed towards the fidelity of the DNA molecule. Along with numerous interacting enzymes and other molecules working in split second accuracy and timing to synthesize, proof read, repair and eventually produce a newly synthesized strand of DNA with error s at the rate of one per 100 million nucleotides (Alberts et al., 2002). The fundamental process of replication can be considered in three phases-- initiation, elongation and termination.
Fundamental requirements for DNA replication
For the smooth and successful integration of the different molecule r events leading to the proper mechanism…
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