Do Glial Cells Make You Clever?

Millions are abusing marijuana every day. In fact, 1 out of 7 high school students smoke marijuana more than once a day. Marijuana is taken very lightly and is the most highly used illegal drug. For this reason, society should know its short and long term effects on the brain. Marijuana can effect these two areas emotionally or physically. Also in some cases physical damages causes the emotional response. Although most public information on drugs are funded by anti-drug organizations, hopefully we will still learn these true facts of marijuana in spite of that.

At the molecular level of explanation these processes are dependent on the interplay between glutamate receptors, Ca2+ channels, the increase of intracellular Ca2+ levels, Ca2+-dependent proteins like Akt, ERK, mTOR and neurotrophins such as brain derived neurotrophic factor (BDNF) (24, 25).

Increasing the extracellular potassium reduces the concentration gradient, and less potassium diffuses out of the neuron and into the cell.

Marijuana has been used in the treatment of AIDS, cancer, glaucoma, multiple sclerosis, and chronic pain ("Medical Cannabis."). Researchers have been trying to explain the negative effects that marijuana can have on the central nervous system and how it hinders memory as well. The constant reports of short-term memory loss by heavy marijuana users brings up the question, is it the most common long term effect of marijuana use? Although it is said that marijuana has many effects such as exhaustion, increased appetite, offset sense of time, and bloodshot eyes, short-term memory loss is the symptom most frequently linked with the use or ingestion of marijuana. But why? Why does using marijuana have any impact on a person’s memory at all? Countless scientists have been working tirelessly to find an answer for this question. The active ingredient in marijuana, THC, is known to attach itself to areas of the brain linked to memory. When the scientists injected lab animals with THC at Rutgers University, they found that they acted as though there was no rhythm to their thought. It affected the hippocampal circuits in the brain to produce animals that were acting normal but in a delayed or offset manor.

In reality, marijuana has the effect of slightly increasing alpha-wave activity in your brain. Alpha waves are generally associated with meditative and relaxed states, which are, in turn, often associated with human creativity

Not only are the toxic levels of alcohol much greater than those of marijuana, but the consequences of drinking long-term are far more damaging as well. Next to smoking tobacco and being overweight, drinking alcohol is the third leading cause of preventable death in the United States. Not including all the accidents and homicides that are attributed to the use of alcohol, the number of people that suffered alcohol induced deaths was 20,687 in 2003 alone (Foland). Those who choose to drink face the risk of many different health conditions, including some cancers, liver cirrhosis, liver disease, and heart disease---not to mention the risk of physical dependency (“Alcohol vs. Marijuana”). The effects on the brain are just as detrimental. In contrast to the old myth that drinking alcohol kills brain cells, recent studies have shown that instead it prevents new cells from being made. This process of making new cells, called neurogenesis, was found to be decreased by over fifty percent in abusers of alcohol. Marijuana seems to have the opposite effect. The same study showed that the use of marijuana actually increased neurogenesis, thus increasing the making of new brain cells (Wenk). Recent studies

People believe that cannabis has no harmful effects on the human brain but that is where they are wong. Teens face much higher risks due to the fact that their brains are not yet fully developed. “Cannabinoids exert their influence by regulating how cells communicate—how they send, receive, or process messages. Cannabinoids act like a type of “dimmer switch,” slowing down communication between cells” (Carah). The article further goes on to explain how marijuana can affect the brain for teens as well as for adults and how it can affect certain parts of the brain in different ways.

"That THC could be a potential therapeutic treatment option for Alzheimer's through multiple functions and pathways" (Cao, et al, 2014).

One region of the brain that contains a lot of THC receptors is the hippocampus, which processes memory. When THC attaches to receptors in the hippocampus, it weakens short-term memory. The hippocampus also communicates with other brain regions that process new information into long-term memory. In the brain, under the influence of marijuana, new information may never register, and may be lost from memory.

There are several chemical processes involved when marijuana enters the brain, and it is important to know what these processes are in order to better understand marijuana’s adverse effects on memory. Though there are many chemicals in marijuana, there are only two main ingredients linked directly to the cognitive effects of the drug. The principal psychoactive component in cannabis is delta 9-tetrahydrocannabinol (Δ9-THC), it is linked to the adverse effects of the drug on various cognitive functions, including memory (Schoeler and Bhattacharyya, 2013). The second

Astrocytes have been shown to communicate amongst themselves, as well as participate in bidirectional communication with neurons via the 'Tripartite synapse '. Ca2+-dependent glutamate release also

The article, “Marijuana and the Teen Brain”, from the Scientific American journal, Claudia Wallis, argues that marijuana negatively affects the teenage brain. Wallis begins her argument by stating her viewpoint on the drug and then proceeds to provide information to support her stance. Multiple studies by scientists/researchers are cited in this article including those based on x-rays of a marijuana user’s brain and others that tested marijuana users on their cognitive skills. Wallis additionally mentions a study on rats which tested the effects of THC. The author provides background information on marijuana to give the reader a better understanding of the concept. This source supports the argument that marijuana use has negative impacts on the human brain because the author also stands behind that argument. Wallis discusses these negative impacts and provides evidence to support her claim. This source cites various studies in which researchers tested the effects of marijuana on the brain which reinforces the argument that marijuana has abnormal effects on the human brain.

Increasing extracellular K+ reduces the net diffusion of K+ out of the neuron through the K+ leak channels because the membrane is permeable to K+ ions. Therefore, the K+ ions will diffuse down its concentration gradient from a region of higher concentration to a region of lower concentration.

Many regions of the brain contain cannabinoid receptors, of which anandamide molecules, concerned with regulating mood, appetite and emotions, naturally bind to. Cannabis contains an active ingredient known as ‘delta-9-tetrahydrocannabonic’ (THC), and when smoked or eaten, the THC imitates the activity of anandamide by binding to cannabinoid receptors on nerve cells, and therefore influences

The authors took extracellular electrophysiological recording to examine the functional change from hippocampus on parabionts. They found isochronic parabionts stayed at baseline level for long-term potentiation, but can be maintained at above baseline level in heterochronic parabionts. From these functional results, they concluded that young blood is capable to potentiate synaptic plasticity in aged mice.