Do Oral Mechanical Bowel Solutions Cause C. Difficile Infection?

3369 Words Dec 27th, 2014 14 Pages
DO ORAL MECHANICAL BOWEL SOLUTIONS CAUSE C. DIFFICILE INFECTION?

INTRODUCTION:
Bowel preparation traditionally consists of cathartics, oral antibiotics, and intravenous antibiotics. Previous studies have shown a strong relationship between the use of antibiotic bowel preparations and a higher rate of postoperative Clostridium difficile colitis due to disruption of the normal enteral microflora. Little data exists to show the relationship between the use of oral mechanical bowel solutions and the development of Clostridium difficile colitis. The aim of this study is to see whether oral mechanical bowel solutions, by themselves, can be implicated as causative agents in the development of Clostridium difficile colitis.

HYPOTHESIS:
We hypothesize that the use of mechanical bowel solutions will result in a higher rate of post procedural Clostridium difficile colitis.

DESIGN:
This is a retrospective study of colonoscopies, and elective colon & rectal surgery patients between the years July 2002 – February 2012.

SETTING:
The study was conducted at an academic community hospital.

PATIENTS:
Records of patients who underwent colorectal surgery or colonoscopies (n = 24,522) were examined by using CPT codes. Patients with bowel obstruction or emergent operations were excluded. Patients who were on antibiotics for other reasons prior to their elective surgery and/or during their current hospital stay after their surgery were also excluded.

MAIN OUTCOME MEASURE:
Detection…
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