Domperidone Maleate Case Study

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4. DRUG AND EXCIPIENT PROFILES
4.1 Drug profile: Domperidone maleate. (73, 74, 75)
Synonym
Apo Domperidone, Domidon
Description
Domperidone Maleate is a white or almost white powder. It shows polymorphism. It is specific blockers of dopamine receptors. It is administered orally, rectally or intravenously. It is given to relieve from nausea and vomiting, as prokinetic agent through increase in gastrointestinal peristalsis and to increase lactation
Structure

Figure 4.1: Structure of Domperidone Maleate
Molecular Formula C22H24Cl N502.C4H4O4
Molecular weight- 541.98
IUPAC Name 5-chloro-1-(1-[3-(2-oxo-2, 3-dihydro-1H-benzo[d]imidazol-1-yl) propyl] piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one maleate
Brand Name: Avistal , Casdom , Diprodom, Domact
Half life: 7 hours
Use
It is in treatment of gastroesophagial reflux disease, Nausea and vomiting, Parkinson’s disease,
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4.2.7. Magnesium stearate (76)
Synonyms
Metallic stearic; magnesium salt
Non-proprietary name NF- Magnesium stearate BP/EP- Magnesium stearate
Empirical formula- C36H70MgO4
Chemical names Octadecanoic acid; magnesium salt; magnesium stearate
Molecular weight- 591.3
Density (He): 1.03-1.08 g/cm3
Bulk volume: 3.0-8.4 ml/g
Tapped volume: 2.5-6.2 ml/g
Functional category Tablet and capsule lubricant
Description
It is a fine, white, precipitated or milled, impalpable powder of low bulk density, having a faint characteristic odour and taste. The powder is greasy to touch and readily adheres to the skin.
Solubility
Practically insoluble in ethanol, ethanol (95%), ether and water, slightly soluble in benzene and warm ethanol (95%)
Stability and storage conditions:
Stable,non-self polymerizable. Store in a cool, dry place in a well closed container.
Incompatibilities
Incompatible with strong acids, alkalis, iron salts and with strong oxidising materials.

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