Dopamine Agonist Case Study

Parkinson 's disease is a progressive neurologic degenerative disease of the Central Nervous system. The brain produces Dopamine and Norepinephrine, which are chemicals needed for smooth muscle movement and coordination, heart rate, and blood pressure. Dopamine and Norepinephrine are released by basal ganglions that are produced in a bundle of nerve cells in the brainstem called substantia nigra. In Parkinson 's patients, the substantia nigra are destroyed and neither of the chemicals can be released into the body. (3) The decrease in Norepinephrine causes heart arrhythmia and low blood pressure, causing the person to get dizzy upon standing or tire easily. The lack of Dopamine, the smooth muscle movement and coordination controller is now gone, or significantly decreased, resulting in the first signs of Parkinson’s disease, pill-rolling, a one handed tremor and a decreased appetite. (2)

Of the six most common neurotransmitters, dopamine is probably the one people know the most about. Dopamine is involved in controlling the reward and pleasure system in the brain. It allows us to recognize rewards and helps give us the ability to go after them. Learning, behavior, and cognition are also affected by dopamine levels. As with anything, if you have an imbalance, then bad things can happen. Parkinson’s disease can be caused by low dopamine amounts. People who have low dopamine levels can be addicted to substances easier.

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

This brain disease requires the need of a certain substance to make a person feel entertained or calm. “Process addictions is a brain disease expressed in the form of compulsive behavior” (Addiction is a brain disease). A person does not think of what they do at the moment until they realise how bad their motive may be . “All the person wants to feel is the neurotransmitter dopamine to feel enjoyment by rewarding their self” (Dopamine neurotransmitter).

Some dopaminergic (i.e., dopamine-releasing) neurons run from the substantia nigra to the corpus striatum; their loss gives rise to the clinical manifestations of Parkinson's Disease (Korczyn 1994); others, involved in the rewarding effects of drugs and natural stimuli, run from the mesencephalon to the nucleunucleus accumbens.

79). Overall, this is a problem, because there continues to be a lack of the public endorsement and support of those seeking treatment regardless of the addiction. Individuals suffer with addictive behaviors for many reasons that include genetic factors. These things are uncontrollable and are harder to be prevented. Inaba and Cohen (2014) stated, “One of the genes that signals a susceptibility to compulsive overreaction” (p. 7.47). The new definition of addiction non/substance and behavior is now based on the psychoactive drugs and certain behaviors that produce the surge of dopamine in the midbrain are biological substrate for addictive behavior (Smith, 2012). Overall, it is important to include all addictive behaviors and substance abuse when diagnosing individuals. It is more important to treat all conditions or addictions than it is to assume that it is not as an important or one is more problematic than one or the

Parkinson’s is a progressive neurodegenerative disease, primarily affecting voluntary, precise, and controlled movement. Parkinson’s occurs when cells in a part of the brain called the substantia nigra die off. These cells are responsible for producing dopamine. With less and less dopamine, a person has less and less ability to regulate their movements, body and emotions. The terms "familial Parkinson's disease" and "sporadic Parkinson's disease" are used to differentiate genetic from truly idiopathic forms of the disease.

Furthermore Parkinson’s disease, which is associated with a depletion of dopamine display behaviours characteristic of schizophrenia when given too much L-DOPA, a dopamine stimulant (Gershon, Angrist, and Shopsin, 1977 as cited in Kalat, 1992). In addition if schizophrenics are given drugs such as L-DOPA their symptoms are heightened. (Kalat, 1992).

Ok, let's talk about BØRNS. I'm actually a bit ashamed. I hadn't discovered him until earlier this year and I'm disappointed in myself. This guy is amazing. His album Dopamine has to be one of my current favorites. For someone who isn't "HUGE" on the scene, he's done a lot. How many artists can say they've toured with Halsey, played Coachella, and had their song in every other commercial. I first heard his song "10,000 Emerald Pools" and later I got into his music. Quickly. "Electric Love" is hard to avoid at this point but that's totally ok. It's a catchy song with a good beat and his voice is in-frickin-credible. That song and "American Money" have very easily become some of my playlist favorites because there's some soul to them. It's not

Parkinson’s Disease is a long-term progressive neurodegenerative disease consisting of motor system impairment, neuropsychiatric, and nonmotor features. The disease is characterized by the following key clinical features: bradykinesia, resting tremor, postural instability, and rigidity. These symptoms are due to the diminishing of dopamine in the nigrostriatal pathway and substantia nigra, which causes inhibition of the thalamus decreasing excitatory input to the motor cortex.1 Along with the key manifestations an individual with Parkinson’s Disease will experience problems associated with the disease or the antiparkinson medications. These co-occurring problems are hallucinations, dementia, daytime sleepiness, fatigue, depression, and pyschosis.2 Psychosis is a common problem in Parkinson’s Disease, and is characterized by paranoid delusions and hallucinations that are visual in nature.2 Risk factors for psychosis consists of advancing age, dementia, sleep disorders, and high doses of antiparkinson drugs.1

Dopamine is a brain chemical/Neurotransmitter that work as messenger signal between the Substantia Nigra to the next relay station of the brain, the corpus striatum which helps to produce smooth coordinate movement and also plays a major role to help control muscle’s movement. With Parkinson’s disease, the brain cells that produce dopamine slowly die, which lead to decrease production of Dopamine. The loss of dopamine causes abnormal nerve firing with brain and the cells that control muscle’s movement by sending the messages to the muscles; due to this it becomes really hard to control muscles movement and cause tremors and various other symptoms such as rigidity and difficulty walking and performing daily tasks. Dopamine is not the only neurotransmitter involved in Parkinson’s Disease. Norepinephrine is very relatively close to dopamine and is also involved in Parkinson’s Disease. Individuals with Parkinson’s Disease have loss of nerve ending that produce norepinephrine. Norepinephrine is a major neurotransmitter for sympathetic nervous system, which control many autonomic functions of our body; it causes increase in blood pressure and heart rate. Loss of norepinephrine can help us explain the non-motor symptoms associated with Parkinson’s Disease such as fatigue, decrease in gastric stability and disruption in cognition. Parkinson’s Disease can be hereditary

Most notable diseases include Parkinson's, Schizophrenia, depression, and ADHD. These diseases occur when the dopamine levels in the brain are imbalanced. Schizophrenia occurs when a person's brain has an exorbitant amount of dopamine. This is also the case with other mental diseases such as bipolar disorder. Treatment usually includes a medication with a dopamine inhibitor, which limits the pace of dopamine transferring from one neuron to another. On the opposite end of the spectrum, diseases such as ADHD and depression are associated with lack of dopamine production (Alban 2017). Parkinson's is caused by the degeneration of the parts of the brain that manufacturer's dopamine (2017). All of these diseases are tremendously critical and should not be taken

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,

In the article “Dopamine and Teenage Logic” by Daniel Siegel he states that “Dopamine is a neurotransmitter central in creating our drive for reward” (Source B). This indicates that dopamine is one of the key causes of risk-taking. Teens often take risks because they are focused on the reward they get after they take it, rather than what would actually happen to them during and after they take the risk. There are two significant ways that dopamine affects our brains; increased impulsiveness, and the susceptibility to addiction by the release of dopamine.