other rapidly growing cells in the body. Chemotherapeutic drugs used to treat cancer are given to most of the people, which help to sustain the completion of cancer treatment (El-Sayyad et al., 2009; Sundaram & Sangavai, 2009). Besides this, the noxious side effects of chemotherapeutic agents include the devastating production of reactive oxygen species (ROS). Therefore, an escalating amount of facts suggest that a simultaneous treatment of chemotherapy and chemo-preventive agents with antioxidant action may augment the efficacy of chemotherapeutics (Lee et al., 2008;Aydin et al., 2011). Although the mechanism underlying the severe cytotoxicities of doxorubicin (DOX) is not fully clear, ROS are assumed to be a key factor in the toxicity of DOX and events controlling this oxidative injury are extensively appreciated (Reddy …show more content…
(Kambas et al., 2013)
Although DOX is an effective chemotherapeutic, dosage in patients is limited clinically due to severe cardiac toxicity (weinstein et al .,2000 ; singal et al ., 2000) The clinical efficacy of DOX, particularly for long term treatment, is limited by the induction of hepatic and cardiac toxicities that are frequently lethal (saad et al .,2001).
Moreover, side effects of DOX due to oxidative stress. Increased lipid peroxidation, reduced antioxidant, free radical trapping capacity in plasma and a marked reduction of tissue Glutathione (GSH) levels are frequently reported during doxorubicin (Concalves et al., 2009).
The enhanced production of reactive oxygen species (ROS) damages normal tissues and therefore results in toxic side effects of chemotherapeutic agents. However increase use The chemotherapy(DOX) is accompanied by various side effects such as vomiting, diarrhoea, anorexia, lethargy, fever, alopecia, anaemia, neutropenia etc. (Sorenmo,2003)
Some of the immediate physical complaints include constantly feeling cold, bloodshot eyes with dark circles, finger calluses, dizziness, weakness, lackluster hair, moodiness, insomnia, no menstruation, swollen glands, weight loss, sore throat, or dry skin. Some of the long-term effects include extreme weight loss, gastrointestinal pain, diarrhea and/or constipation, malnutrition, loss of tooth enamel,
Exposure to Agent Orange or dioxin is also associated with disorders of the endocrine system (e.g., decreased sexual desire, gynecomastia), cardiovascular system (e.g., increased blood pressure, blood deficiency), gastrointestinal system (e.g., nausea, vomiting,
Relevant interactions: Diuretics - hypokalemia, predisposing patient to digitalis toxicity. Antacids - decreased absorption of oral digoxin.
Chemo have a lot of side effects. Like loss of appetite, being nausea, vomiting, weakness , mouth sores , hair loss, weight loss, diarrhea or many more effects. (Ty)
Chemotherapy is the administration of chemicals into the body in an attempt to cure/lessen the severity of cancer in living organisms. Chemotherapy is always given with a curative intent, but that cannot always be promised to the patient, so sometimes it is given to relieve symptoms that the patients are experiencing or to improve their overall quality of life.1 While chemotherapy is used as an agent to try to rid individuals of their cancer, it is essentially slowly killing them. The chemicals used for the treatment are toxic to the human body and while they are giving them in small amounts, those small amounts accumulate over time to large amounts in the body. The body is affected by the treatment in various different ways and every body
nausea. Her decision to quit the treatment was easily supported by her parents, however when
Niosomes can alter the metabolism; prolong circulation and half life of the drug, thus decrease the side effects of antineoplastic drugs. Niosomally entrapped methotrexate and doxorubicin showed beneficial effects over the free drug, such as decreased rate of proliferation of the tumor and higher plasma levels accompanied by slower elimination (9).
CHRONIC MILD TO MODERATE TOXICITY (MDX): Toxicity can range from asymptomatic ALT elevation to malaise, nausea, vomiting, abdominal pain, and hepatotoxicity.
I experienced a drug reaction to Doxycycline Hyclate a little over a year ago. I had visited my dermatologist with concerns about acne. I had never had acne before, then all of a sudden, it seemed to be popping up everywhere. She decided that I should be put on Doxycycline, and said that it usually helped clear up acne. I was told to take one tablet daily, and that I should also take it on an empty stomach. I remember being at school when I had some unpleasant side effects to taking the drug. I took the tablet on an empty stomach, as I was advised. It was early in the morning, and the pill did not sit well with me. I became dizzy, had a fever, chills, and my vision started to become blurry. I was very concerned, and worried that something wasn't
Pain, burning, or itching of the treated skin may occur. Skin and mucous membranes (such as the gums) may become blue/gray in color. Apart from this some serious side effects as mentioned below may also occur: signs of infection (such as fever, chills, persistent sore throat), easy bleeding, signs of anemia (such as unusual tiredness/weakness, rapid breathing, fast heartbeat), change in the amount of urine, pink/bloody urine, signs of liver problems (such as stomach/abdominal pain, persistent nausea, vomiting, dark urine, yellowing eyes/skin), mental/mood changes. Several cases of transient leukopenia have been reported in patients receiving AgSd therapy.
There are so many risks associated with the use of chemotherapy drugs to treat cancer. The major reason for this is that, chemotherapy drugs works on both normal cells and cancer cells. Therefore, while killing cancer cells, it kills normal cells as well. Additional risk can arise from overdose, extravasation (when an injected drug finds its way from the intended vessel to surrounding tissues) from cancer injections and serious damage to important organs of the body. Thankfully, drugs like Totect (Dexrazoxane Hydrochloride) have been developed to combat the effects of any risk that manifest in patients while undergoing chemotherapy.
Systemic treatment is regularly utilized as a part of conjunction with different modalities that constitute "nearby treatment" (i.e. medications whose adequacy is limited to the anatomic territory where they are connected) for growth, for example, radiation treatment, surgery, and/or hyperthermia treatment. The adequacy of chemotherapy relies on upon the sort of tumor and the stage. The general viability ranges from being corrective for a few growths, for example, some leukemias, to being inadequate, for example, in some mind tumors,to being unnecessary in others, as most non-melanoma skin cancers. Clinical information has indicated docetaxel to have cytotoxic movement against bosom, colorectal, lung, ovarian, prostate, liver, renal, gastric, head and neck tumors, and melanoma. In hormone unmanageable prostate growth docetaxel enhances future and general life quality. Docetaxel has a place with a class of chemotherapy medications called plant alkaloids. Plant alkaloids are 5produced using plants. The vinca alkaloids are produced using the periwinkle plant. The taxanes are produced using the bark of the Pacific Yew tree. Vinca alkaloids and taxanes are otherwise called antimicrotubule operators. Treatment with docetaxel has the particular result of expanding survival time in patients with certain sorts of tumor. Some clinical trials show median survival times to be expanded by just three months,
In most controlled clinical studies, the incidence of adverse reactions in individuals that were treated with famotidine was identical to those on placebo. Yet some adverse reactions seen at a rate above 1% and that may have been caused by the drug are: headache 4.7%, dizziness 1.3%, constipation 1.2% and diarrhea 1.7% (PD-Rx Pharmaceuticals, 2015). PD-RX Pharmaceuticals, Inc. have also reported mood swings, agitation, confusion, depression, irritability, hallucinations and insomnia in some rare cases. These reactions of this type on the central nervous system occur more often in elderly patients and those with renal failure. Seldom dermatologic reactions have occurred, although there have been reports of urticaria, pruritus, and alopecia. Other adverse reactions whose causality is not well established include myalgia, tinnitus, dysgeusia, paraesthesia, flushing, fever, fatigue, and palpitations (PD-Rx Pharmaceuticals,
According to Gould’s Pathophysiology for the Health Professions book, one of the common drug-nutrient an interaction with methotrexate is that happens with the prostaglandins (any of a group of cyclic fatty acid compounds includes the omega-3). There is a raise in incidence of heart attacks and strokes that associated with using these drugs together.
Most cancer medicine has several adverse effects and busulfan is not an exception. Besides its positive effects, bulsufan has several side effects which include “anemia, seizures, heart failure, cerebral hemorrhage, pulmonary fibrosis, confusion, headache, depression, nausea, vomiting, unusual tiredness, muscle and joint pain”. (Drugs.com, busulfan, 2016). The physical therapy implications must be put into consideration when treating patients on busulfan. Some patients experience seizures, particularly at the beginning of the drug treatment. Therapist must be watchful for new or recurrent seizure episodes and notify the physicians at once. Busulfan is associated with increased risks of heartache and the therapist should be alert for signs such as peripheral edema,