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Doxorubicin (DOX)

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other rapidly growing cells in the body. Chemotherapeutic drugs used to treat cancer are given to most of the people, which help to sustain the completion of cancer treatment (El-Sayyad et al., 2009; Sundaram & Sangavai, 2009). Besides this, the noxious side effects of chemotherapeutic agents include the devastating production of reactive oxygen species (ROS). Therefore, an escalating amount of facts suggest that a simultaneous treatment of chemotherapy and chemo-preventive agents with antioxidant action may augment the efficacy of chemotherapeutics (Lee et al., 2008;Aydin et al., 2011). Although the mechanism underlying the severe cytotoxicities of doxorubicin (DOX) is not fully clear, ROS are assumed to be a key factor in the toxicity of DOX and events controlling this oxidative injury are extensively appreciated (Reddy …show more content…

(Kambas et al., 2013)

Although DOX is an effective chemotherapeutic, dosage in patients is limited clinically due to severe cardiac toxicity (weinstein et al .,2000 ; singal et al ., 2000) The clinical efficacy of DOX, particularly for long term treatment, is limited by the induction of hepatic and cardiac toxicities that are frequently lethal (saad et al .,2001).

Moreover, side effects of DOX due to oxidative stress. Increased lipid peroxidation, reduced antioxidant, free radical trapping capacity in plasma and a marked reduction of tissue Glutathione (GSH) levels are frequently reported during doxorubicin (Concalves et al., 2009).

The enhanced production of reactive oxygen species (ROS) damages normal tissues and therefore results in toxic side effects of chemotherapeutic agents. However increase use The chemotherapy(DOX) is accompanied by various side effects such as vomiting, diarrhoea, anorexia, lethargy, fever, alopecia, anaemia, neutropenia etc. (Sorenmo,2003)

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