In its 2014 Global Tuberculosis Report, the WHO stresses DR-TB poses a major threat to the control of TB worldwide.
Currently, an estimated 3.5% of new cases of TB and 20.5% of previously treated cases have MDR-TB. In 2013 there were an estimated 480 000 new cases of MDR-TB and 210 000 deaths. On average 9% of people with MDR-TB have XDR-TB.
Although there has been progress in the detection of DR-TB through the use of new rapid diagnostics, gaps between diagnosis and treatment have widened in several countries recently.
In terms of treatment, only five of 27 high MDR-TB burden countries achieved a treatment success rate of ≥70%. Health system weaknesses, lack of effective regimens and other treatment challenges are responsible for the
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I will include recommendations to address the aforementioned priorities.
Definition, Transmission and Treatment
The two forms of DR-TB are defined as follows: “Multidrug-resistant tuberculosis (MDR TB) is a form of tuberculosis that is resistant to two or more of the primary drugs (isoniazid and rifampin) used for the treatment of tuberculosis; and Extensively drug-resistant tuberculosis (XDR TB) is tuberculosis that is resistant to at least isoniazid and rifampin among the first-line anti-TB drugs and is resistant to any fluoroquinolone and at least one of the three second-line injectable drugs.” XDR is thus an evolution of MDR-TB. The two main causes of DR-TB in an individual are, first, through the interruption of antibiotic treatment during regular tuberculosis therapy whereby the amount of drug in the body is reduced to levels insufficient to kill the bacteria. The interruption is most commonly caused by: “the patient choosing not to complete the full course of treatment; a rupture in the patient’s drug supply, poor drug prescription – wrong drug, dose or length of treatment; and/or poor quality of drugs.” Resistance to one or several forms of treatment then occurs when the bacteria develops the ability to withstand the antibiotic attack. The second cause of DR-TB infection occurs when this resistance, subsequently passed on to the bacteria’s offspring, creates of a whole strain of resistant bacteria that can then be spread from one person
The CDC website provides ample educational information regarding tuberculosis. It gives a detail description of what Tuberculosis is, the testing used and how it works. The website also addresses the risk factors of tuberculosis and warns that traveling to countries such as Africa, Asia and Central America puts them in a higher risk of contracting TB. In addition, it provides people with preventive measures to avoid being infected. They advise against close proximity with infected, and to be cautious around people working in health care facilities, prisons, shelter or an over populate area and advise to refrain from consuming unpasteurized milk products. In addition, the Website provides Data and Statistics, which can help support previous
TB is still proven to be a top killer around the world, and with more cases of drug resistant TB being reported daily, the cost of treating and preventing this disease will continue to be on the rise.
Tuberculosis is a disease cause by a bacterium that spreads when a person infected with the virus, sneezes, coughs, or even talks and the germs make it into the air for another person to breathe. This bacterium primarily affects the lungs and prevents the proper functioning of the respiratory system. Tuberculosis continues to be a problem in the United States and the problem is even bigger in developing countries such as India where they have seen the growth of MDR-TB cases. The following annotated bibliographies include a variety of peer review journals, a CDC website and the RX for survival video, which addresses the burden of tuberculosis in different parts of the world. The bibliographies also look at the risk factors, prevalence, mortality,
Once believed to be easily treated and prevented, Tuberculosis (TB) has recently been making a steady comeback. Previous to modern medicine, TB claimed millions of victims, spreading from person to person like wildfire. Around the 17th-18th centuries, the “White Plague” took the lives of 1 in 5 adults (20%) in Europe and North America (Iseman, 1994). However, as technological advances progressed, this seemingly ferocious viral disease became a primal, insignificant thing of the past. But, in the nature of all bacteria, TB has, in the recent years, mutated to become progressively drug resistant. Why is Tuberculosis coming back with a vengeance? Well, the answer’s quite simple. TB has done an amazing job of standing in the corner and
In 2014, 100,000 people out of a two hundred million population died from tuberculosis disease and the incidence of TB was estimated to be 1,000,000 TB cases (Kanabus, 2016). “Prevalence of all tuberculosis (TB) cases (include pulmonary, musculoskeletal, etc.) in Indonesia on 2014 was 234 per 100.000 cases” (Albana, Purba, Manihuruk, & Ariff, 2016, para. 2).
Tuberculosis is a disease of an infectious nature caused by a bacterium known as mycobacterium tuberculosis. The disease spreads through the air. People with the disease can spread it to susceptible people through coughing, sneezing, talking or spitting. It mainly affects the lungs and other parts such as the lymph nodes and kidneys can also be affected. The symptoms for TB are fatigue, coughing, night sweats, weight loss and fever. One third of the population of the world is affected with mycobacterium tuberculosis. The rate of infection is estimated to be one person per second. About 14 million people in the world are infected with active tuberculosis. Drug resistant TB has been recorded to be a serious public health hazard in many countries. Resistant strains have developed making it difficult to treat the disease. TB has caused millions of death mainly in people living with HIV/AIDS ADDIN EN.CITE Ginsberg19981447(Ginsberg, 1998)1447144717Ginsberg, Ann M.The Tuberculosis Epidemic: Scientific Challenges and OpportunitiesPublic Health Reports (1974-)Public Health Reports (1974-)128-13611321998Association of Schools of Public Health00333549http://www.jstor.org/stable/4598234( HYPERLINK l "_ENREF_3" o "Ginsberg, 1998 #1447" Ginsberg, 1998). The World Health Organization came up with the DOTS (Directly Observed, Therapy, Short course) strategy. The approach involves diagnosing cases and treating patients with drugs for about 6-8
TB is an unevenly spread disease due to structural violence and cultural arrangements present in today’s society. These unnatural causes create a social and medical barrier that makes TB more
Tuberculosis is a global problem that has affect the lives of many people. Though the rates very decreased immensely many third world countries still have very high rates of people infected with TB. Per the CDC: Rhode Island Health Profile, Rhode Island is 16th among the 50 states in the rates of TB (2015). Rhode Island has the 3rd high rate within the New England. Also, per the Health Department of Rhode Island, the highest rates reported in Rhode Island were in the states capital, Providence. The state of Rhode Island has a case rate of 2.8 per 100,00 people (Centers for Disease Control and Prevention [CDC], Leveling of Tuberculosis Incidences, 2016). There were 30 cases reported in RI in 2015. According to the World Bank, the incidence rate
Nowadays, wе arе witnеssing a rеsurgеncе of thе rolе of surgеry in managing TB duе to thе ovеrall incrеasе in global incidеncе, and thе еmеrgеncе of multidrug-rеsistant TB (MDR-TB, rеsistancе to both Isoniazid and thе Rifampicin) or еxtеnsivе drug rеsistant TB (XDR TB, rеsistancе to Rifampin and Isoniazid, to fluoroquinolonеs and at lеast onе of thе following injеctablе anti-TB drugs: Caprеomycin, Kanamycin, or Amikacin) (Sihoе, 2009; Hеaton, 2014).
Tuberculosis (TB) is the second most common ancient infectious disease (Tiwari et al., 2005). It is caused by mycobacterium tuberculosis (M. Tb) which is an aerobic, intracellular pathogen inhabits in oxygen rich regions of the lungs. According to World Health Organization 9 million people affected with TB infection in 2013 and about 1.5 million patients died from this disease. Worldwide predictions for tuberculosis control are challenged by the development of drug-resistant strains, especially those that are multidrug resistant (MDR) and extensively drug resistant (XDR). In 2013, approximately 5% (480000 people) of TB patients were found to be multidrug resistant (MDR-TB).
Years and years of research by doctors and scientists only added up to a little progress against TB. At
In 1990s, a policy was engineered in New York and the high prevalence of TB (similar to London) was managed and controlled. In 2004, the Department of Health launched a report adopting those action plans, aiming to bring TB under control, based on the following ten points, (Davies, P. (2005))
The Primary goal of the study was to examine the distribution of DM among TB patients and explore the risk of Drug resistant TB in Diabetics who are also infected with TB in Florida, USA. The Florida department of health TB control program aims to eliminate TB in the state through TB care initiative, A Florida system of Tuberculosis care formed by partnership between the Florida Department pf Health (FDOH) and the public health system statewide to ensure availability of effective TB management program, an aim in line with the global plan to stop TB 2016-2020 adopted by WHO has a post 2015 strategy to eliminate TB as a global epidemic by 2035.
While Western religions are male-centered, the largest pilgrimage site is in North India i.e., Vaishno Devi. Across the country can be seen places of pilgrimage centered on the shrines of the various forms of Goddess like Durga, Parvati, Kali, Lakshmi, Saraswati, etc. The Shakta Hindus consider the Mother Goddess to be the Supreme Creator and even Vaishnavites and Saivites, who worship Lord Vishnu or Lord Siva as the Supreme Deity, affirm that God cannot be approached except through His Shakti. Child marriage was not known in the Vedic period.
India, the second most populous country with over 1.31 billion people, has the highest burden of tuberculosis (TB) in the world, accounting for 20% of the global incidence of TB, and an even higher share of global incidence of multi–drug resistant (MDR) TB. With an estimated 2 million new cases of TB and 5, 00,000 TB-related deaths in India annually, those who got diagnosed with different forms of DR-TB were 35,385 cases but only 20,753 people started on multidrug-resistant TB (MDR-TB) treatment in 2013. The National Tuberculosis Program was launched in 1962, but suffered heavily continuing TB led mortality. Acknowledging this reality, a Revised National Tuberculosis Control Programme (RNTCP) was launched by the Government of India in 1997, however even today it does not comply with World Health Organization (WHO) recommendations.