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Drug And Secondary Prevention Of Stroke And Transient Ischaemic Attack

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Greg Kalita trainee pharmacist independent prescriber 2016

A review of ACE inhibitors use in the secondary prevention of stroke and transient ischaemic attack

Summary

An angiotensin-converting-enzyme (ACE) inhibitors use in the management of hypertension and secondary prevention of stroke is supported by NICE guidelines, and is effective with a favourable side effect profile.

Combination therapy with ACE inhibitor plus diuretic (indapamide) reduces blood pressure and stroke risk by 43% (PROGRESS Group Lancet 2001 September)

Results from HOPE (Yusuf et al Engl J Med. 2000 Jan 20) and PROGRESS trials established that long-term management of BP (blood pressure) after stroke with ACE inhibitors (perindopril or ramipril) and diuretics (indapamide) reduces the risk of recurrent stroke (and cognitive impairment).

After a stroke or TIA (transient ischaemic attack), 'normotensive ' patients benefit as much as hypertensive patients from BP reduction.(South&Devon Formulary Secondary prevention of stroke / TIA 2015)

Key Recommendations

Patients who have had a previous stroke or TIA who are clinically stable and have no contraindication to antihypertensive therapy should aim to gradually lower

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