Drug Delivery Via The Nasal Route

1299 Words Sep 16th, 2016 6 Pages
Introduction

In the past years, drug delivery via the nasal route has established itself as a competitor and an alternative route over other routes of administration. It provides a higher degree of patient compliance and drugs can be painlessly self-administered by the patient (Illum, 2003). Drugs administered through nasal route are absorbed rapidly and can reach therapeutically effective plasma levels quickly due to highly permeable membranes and rich vasculature of the nasal cavity (Majithiya et al., 2006). In addition, the nasal route offers further advantages over the oral route, especially for those drugs that have poor oral bioavailability due to high hepatic first-pass metabolism, pH instability and enzyme degradation in GIT (Ugwoke et al., 2001).

Nowadays, the intranasal route has gained more interest to target drugs to the brain and cerebro-spinal fluid by passing the blood-brain barrier. Intranasal formulation of drugs for the treatment of Parkinson 's disease (Khan et al., 2010), Alzheimer 's disease (Zhang et al., 2004) and psychosis (Kumar et al., 2008) have been elaborated and their therapeutic efficiency over conventional oral dosage form has been verified.

Rivastigmine tartrate (RV) is the drug of choice for the treatment of Alzheimer 's disease that is characterized by progressive memory dysfunction due to significant insufficient levels of acetylcholine in the brain (Williams et al., 2003). RV is categorized in the class of reversible cholinesterase…
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