Essay Drugs: Tolerance and Withdrawal

Addiction is a chronic brain disease that often results in some sort of relapse. Addiction is characterized by inability to control drug use which results in problems with one’s behaviors and interpersonal relationships. This disease causes compulsive behaviors such as the need to use drugs despite the many harmful consequences that affect the addicted individual and those around him or her. Although for most people, the initial decision to use drugs is a one time lapse in judgement, the brain is easily affected by these drugs if the person decides to use these drugs multiple times. The changes that occur to the brain over time will cause the addicted person’s ability to resist the intense impulses of drugs to be altered causing the addict to often give into the temptation of these drugs. Like other chronic diseases, addiction often involves cycles of relapse and remission. Without treatment or engagement in recovery activities, addiction is progressive and can result in disability or premature death. Drug addiction is an issue that many people deal with whether they are the addict or the addict is their loved one; but with a good source of support anyone can over come the challenges and consequences of addiction.

Besides the obvious appeal of the "high" or elation, which occurs subsequent to drug administration, a greater influence leading to an increased dosage and necessitated use, would seem the acquisition of tolerance. There are three subtypes, pharmacokinetic/dispositional tolerance, pharmacodynamic tolerance, and behavioral tolerance which all prove relevant in the drugs of abuse, with the exception of the stimulants (cocaine, methylphenidate, etc). Pharmacokinetic tolerance refers to the changes in substance distribution due to the bodies metabolism of the drug, while pharmacodynamic tolerance addresses the adaptive changes which have taken place within the system thereby reducing the efficacy of the drug. The final, behavioral tolerance, seems perhaps at once the most confusing and most compelling. Behavioral tolerance has to do with the learned tolerance in relation to a specific situation and it's environmental cues by which the body adapts and prepares itself thus minimizing the drugs effect ( 6). Thus the physiological dependence, or the need to administer the drug in order to maintain even a state of normalcy, is a direct result of these developed tolerances. It is the re-setting of the bodies homeostatic mechanisms in order to adapt for the effect of

A common assumption that is made is that people who are addicted to drugs are suffering from a lack of willpower or moral fibre. People assume that these people could stop using if they simply tried a little harder. Unfortunately for those who are addicted, it is not that simple. When someone takes a drug regularly, heroin, for example, their brain chemistry becomes altered. The body produces less natural dopamine and begins to require more and more of the drug to feel its effects. Eventually, the body will begin to crave the drug, and going without it will lead to nasty withdrawal symptoms, including vomiting, increased heart rate, and

First of all, there is the Structural-Functional perspective way people view drug addiction as. The structural-functional perspective is the role the drugs do for the person or the weakening of the norms. It is the way they affect the person and what it does to them that makes them be addicted to drugs. For some people drugs relieves them. It takes them away from their problems from a while and they feel stress free and because of that feeling they receive from the drugs they like it and continue to take more and more. Those with this type of perspective well most likely disagree with this view of drug addiction and would want the problem to decrease.

Addiction claims the user through physiological dependence that creates a need for the drug of choice on a very basic level. Through repeated substance abuse, the user gains tolerance for the drug, needing it in larger amounts, and on a more frequent basis, until the body cannot function normally without the drug. Withdrawal symptoms now also occur upon attempting to halt use. This is how substance abuse becomes the disease of addiction.

Addicts use drugs to overcome their feelings. If an addict is feeling sad, happy, or angry, they use. This leads to their addictions. After a while, the addict can’t hold a steady job,

According to the biological perspective, drug use may start off as casual, but through continued use, it produces changes in the brain that influences the onset and maintenance of drug addiction. (Horvath et al., 2013). Drugs have their most prominent effects on the function of neurotransmitters. Almost all major drugs of abuse activate the reward system and cause a flood in the levels of dopamine which is a neurotransmitter that is involved in pleasure. As a result, not only do people learn to associate drug use with pleasure, but the brain also starts to reduce its own natural dopamine production in adjustment to the levels of dopamine produced by the drugs. This is called tolerance, and the consequences of tolerance are highly influential

Tolerance therefore turns into an addiction by where the body cannot regulate itself without the drug. Addiction is a severe form of substance use disorder (SUD). Along with the symptoms noted with substance abuse, the user now has lost the ability to limit or stop using on their own as symptoms of withdrawal are present if the user attempts to halt use altogether.

Drug addiction is something that everyone is vulnerable to, and that unfortunately is something that many people are going through in today’s society. Everyone is exposed to drug addiction, no matter what, it’s just up to the person to determine if they have a strong enough will power to not take the drugs. However, drugs are available to anyone who is willing to buy them, and many people are willing to spend everything they have in order to buy drugs that might give them temporary relief of a situation that they are currently struggling in; drugs are many people’s escape from the reality they are forced to be in. People have different reasons as to why they start using and abusing drugs; some may choose to do it simply because they like the feeling the drugs causes or occasionally because of the environment or situation the person was or is in, but I mostly think it’s because the person isn’t strong enough to stop taking the drugs or to say no to them.

People feel that way towards addiction simply because the addicts consumption of the drugs were motivated behind the idea of being intoxicated. But anyways, I digress. Similar to other chronic, relapsing diseases, such as diabetes, asthma, or heart disease, drug addiction can be managed successfully. And, as with other chronic diseases, it is not uncommon for a person to relapse and begin abusing drugs again. Relapse, however, does not signal failure; but rather indicates that treatment should be reinstated, adjusted, or that an alternate treatment is needed to help the individual regain control and

All heroin users—not just those who injected the drug—risk becoming addicted. Individuals who abuse heroin over time develop a tolerance for the drug, meaning that they must use increasingly larger doses to achieve the same intensity or effect they experienced when they first began using the drug. Heroin ceases to produce feeling of pleasure in users who develop tolerance: instead, these users must continue taking that dug simply to feel normal.

Drug addiction is a brain disease because drugs change the brain’s structure and how they work. Over a period of time drugs start to affect the brain by challenging an addicted person’s self-control and interfere with their ability to resist intense urges to take drugs. “Most drugs affect the brain's reward circuit by flooding it with the chemical messenger dopamine. This overstimulation of the reward circuit causes the intensely pleasurable "high" that leads people to take a drug again and again. Over time, the brain adjusts to the excess dopamine, which reduces the high that the person feels compared to the high they felt when first taking the drug—an effect known as tolerance. They might take more of the drug, trying to achieve the same dopamine high.”, States National Institute on Drug Abuse. After long term use of drugs it affects functions such as learning, judgment, decision-making, stress, memory, and behavior. Even though an addict knows this, they still use

When people start taking drugs, they don't plan to get addicted. They like how the drug makes them feel. They believe they can control how much and how often they take the drug. However, drugs change the brain. Those who use drugs start to need the drug just to feel normal. That is addiction, and it can quickly take over a person's life.

“The overstimulation of this reward system, which normally responds to natural behaviors linked to survival (eating, spending time with loved ones, etc.), produces euphoric effects in response to psychoactive drugs. This reaction sets in motion a reinforcing pattern that “teaches” people to repeat the rewarding behavior of abusing drugs ”(“Understanding Drug Abuse). Using addictive drugs floods the limbic brain with dopamine, taking it up to as much as five or ten times the normal level. A person with elevated dopamine levels now has a brain that begins to associate the substance with an outside neurochemical reward (“Your Brain on Drugs”). As a person continues to abuse drugs, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. The result is a lessening of dopamine’s impact on the reward circuit, which reduces the abuser’s ability to enjoy the drugs, as well as the events in life that previously brought pleasure. The decrease in normal dopamine levels encourages the addict to keep abusing drugs in an attempt to bring the dopamine function back to normal, except now larger amounts of the drug are required to achieve the same dopamine high, an effect known as tolerance (“Understanding Drug Abuse ). That is what leads to the state of addiction, which leaves the person in a cycle of craving, using, withdrawal, and relapse.

A person’s body, in almost every aspect of its being, is addicted when one is a mild to chronic user and abuser. The nervous system, brain, and muscle tissue are all living in anticipation of the next high. So, for the addict, it is crucial that the cycle of behavior, is broken. The addict needs to pull up the anchor that keeps them from moving forward. This means changing environments, patterns and even sometimes friends and social associates.