Duchenne Muscular Dystrophy ( Dmd )

856 Words Nov 26th, 2014 4 Pages
Duchenne Muscular Dystrophy Genetic Disorder
Introduction to Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is one of many types of muscular dystrophy disorders, which affect the muscle fibers. It is the most aggressive form of muscular dystrophy. The muscle fibers gradually become weaker and incapacitate the affected individual. “DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males (NCBI, 2014).” Males are more susceptible to inherit this disorder because DMD is passed on through the X chromosome. Women can be carriers of the disorder without any adverse affects. The female carrier has a 50% chance of passing on this trait to an offspring. It is extremely rare that a female will have DMD. Symptoms of this disorder include muscle weakness that starts at the legs and progresses at a fast rate though out the body. The rapid progression of muscular dystrophy means that the inflicted individual will eventually be confined to a wheelchair in their life time. “Wheelchair dependency had a median age of 10 years (OMIM, 2013).” Other symptoms include degraded motor skills as well as learning disabilities. As muscle mass diminishes the individual suffers from heart and lung complications eventually leading to the persons’ death. “Death occurred at a median age of 17 years (OMIM, 2013).” The X-linked inherited disease is cased by a mutation in the DNA segment of the X chromosome in the DMD (P11532) gene. This…
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