INTRODUCTION Dyslipidemia is a medical condition of disordered lipid metabolism in the body. Three characteristics of this disorder are elevated serum levels of triglycerides, low-density lipoprotein cholesterol (LDL-C), and low levels of High-density lipoprotein cholesterol (HDL-C). This disorder is seen at all ages, and its etiology is either genetic or of lifestyle choices (1). Therapy has included statins, niacin treatment, and/or a combination of both. Extended-release and immediate-release niacin are used as significant therapy treatments to improve all key lipid subclass conditions in dyslipidemia. However, side effects often occur with high doses of niacin, which may lead to discontinued use (1). This paper will review the effects of …show more content…
Statins have been used to improve serum lipid levels, but are not effective on every lipid subclass alone. Literature supports extended-release niacin’s effectiveness on improving lipid subclass levels, additionally with statins, or alone. The studies in this review support such evidence. Evidence supports combined niacin/statin treatment therapy significantly lowered LDL cholesterol, triglycerides, alipoprotein a, and lipoprotein B, while raising HDL, and Lipoprotein A-1. Evidence also showed that statins are, specifically, more effective in lowering LDL, VLDL, lipoprotein B, and total cholesterol (10). Niacin, however, is more effective at increasing HDL cholesterol, and alipoprotein a, when used alone (10). Another benefit of niacin was the effect it had on lipoprotein particle size. Evidence from the studies showed that niacin and statin treatment effectively increased both LDL-C and HDL-C particle size, while decreasing LDL-C concentration, and increasing HDL-C concentration (3). Most of the participants in these studies ages ranged from early adulthood through late adulthood, but dyslipidemia, and the effect of ER-niacin treatment can be effective for use at any age. Such niacin benefits induce cardio-protective measures, and help decrease coronary artery disease risk, and ultimately congestive heart failure. ER-Niacin has been shown to also to slow the progression of, and may promote the regression of atherosclerosis in dyslipidemia patients on statin therapy (6). The safety of niacin was also considered throughout each study. Overall, treatment therapy of niacin is considered safe, but the flushing side effect contributed to participants withdrawing from study participation, especially when administered high doses (1-2g). Overall, niacin and statins, can aid as dyslipidemia treatments, but only as secondary measures to exercise and healthy lifestyle
He has never been on any statin therapy. His most recent lipids were done in January showing total cholesterol 213, triglycerides 172, HDL 61, LDL is 118.
Cholesterol is a compound chemical that contributes to coronary artery disease, which have a various risk factors which includes poor dieting, smoking, and a family medical history. This disease is very high risks, its one which runs in my family, and family history.
High cholesterol level is a condition in which the concentration of high density lipids (HDL) specifically cholesterol, has significantly increased in the blood. The build up of these lipids in arteries reduce the supply of blood and hence, oxygen to the heart. Consequently, high cholesterol can lead to stroke or heart attack. Apo – Atorvastatin (Atorvastatin Calcium Tablets) is a medication that helps lower the concentration of cholesterol and other HDL in the blood (Apo-Atorvastatin, 2011) and is manufactured by Apotex Inc.
Hyperlipidemia is the abnormal elevation of any lipoproteins present in the blood. HMG-CoA reductase inhibitors (statins) are commonly used for the treatment of hyperlipidemia, specifically lowering the levels of low-density lipoproteins (LDL) levels. As with most classes of medications, there are many potential side effects. A less common but serious side effect of statins is myopathy. Myopathy is a dose-related side effect that causes skeletal muscle weakness, aching, cramping, pain, stiffness and tightness. The mechanism of this occurrence is unknown, but as will be shown, there is a possible correlation between low vitamin D levels and increased occurrence of statin induced myopathy. The vast numbers of patients on statins results in a high number of patients with statin-induced myopathy throughout the world. This consultation will determine whether vitamin D prophylaxis is safe and effective in the prevention of statin-induced myopathy.
The patient was put on a low fat and low cholesterol diet to see if the symptoms would improve and the cholesterol levels would decrease along with some statin medication of Atorvastatin, to help lower the cholesterol within the blood and help to prevent the patient from gaining any associated symptoms that are related with cardiovascular disease. The medication was given as it inhibits HMG-CoA reductase of the enzyme found within the liver that has a huge role in the production of cholesterol. This should show a dramatic reduction in the levels of LDL-C.
Annual testing for abnormalities in fasting serum cholesterol, triglyceride, HDL cholesterol, and calculated LDL cholesterol levels (ADA, 2008)
(b) With treatment…Statin drugs work by blocking the action of the liver enzyme that is responsible for producing cholesterol. Statins lower LDL cholesterol and total cholesterol levels…at the same time, they lower triglycerides and raise HDL cholesterol levels. Statins may also help to stabilize plaques in the arteries. That makes heart attacks less
He tells me that his lipids have been elevated, but he is not going to take statin therapy. He has never been prescribed statins. He has not had his levels checked in the last six
It would be recommended for ML to start a lipid lowering medication like a statin. The National Heart, Blood and Lung Institute recommends moderate to high intensity statins to people who fall into groups such as diabetic patients with a LDL from 70-189 (Ng, P., Toderika, & Cheng-Lai, 2016). ML would fall into this category and would most likely benefit from starting a medication such as a statin.
Treatment with fibrate drugs acting to decrease free fatty acid production on the peroxisome proliferator-activated receptors (PPARs), specifically PPARα is for both the conditions. The synthetic statin drugs, namely, rosuvastatin and atorvastatin can increase hepatic reuptake of LDL due to increased LDL-receptor expression, resulting in the decrease of LDL
A higher level of fats in the body puts the patient at higher risk for Cardiovascular diseases(CAD). The patient's' family has a history of CAD. Her mom and one of her sister have CAD (Lewis et al., 2014, pp. 733-734). The patient states that she has been taking her meds for cholesterol atorvastatin regularly. Her lipase level was 8272 on 11/11/16 and 2829 on 11/12/16 U/L 1069 on 11/13/16 (Ref range 73-393 U/L). Her HDL cholesterol level was 21 ( ref range>49 mg/dl), LDL Cholesterol level 148 ( ref range: <130 mg/dL). Patient statin drug was on hold because it is contradicted on the patient with an elevated level of ALT 80, 61(Ref range 0-50 U/L) and AST 61 on 11/12/16 and 64 on 11/13/16 (ref range 0-45 U/L). The uncontrolled level of could be the cause of concern for stroke or acute myocardial
Dietary Factors in Preventing Heart Disease As coronary heart disease is the leading cause of death in the UK, more attention should be paid to preventing the disease. Many patients suffering from heart disease realise that it was mainly caused by their diet. Research has shown that elevated levels of LDL cholesterol are associated with increased risk of heart disease. “ Studies indicate that for every 1% elevation in the bad cholesterol there is a 2% increase in risk of heart disease”
Some folks don’t tolerate cholesterol medicine. Others just don’t want to take it. When we address cholesterol levels naturally, medications become less necessary. If you refuse cholesterol medication it is advisable to take natural, scientifically based steps, to protect your health. Lifestyle changes, clinical nutrition, botanical medicine and other modalities are used to impact this
Heart disease is the number 1 killer in the United States of America. It’s important to have a heart protection strategy, especially as you get older. It should include exercise and a healthy diet, plus supplements for heart health as needed. Know your cholesterol, blood pressure and ideal weight. Lower risk factors and prevent early disability, illness or even death from heart disease. And although you can't help heredity, you can certainly be aware of any risk factors that may have been passed down through your family tree. After following the steps in this assignments all of the supplements I would recommend along with the information I have given you here are proven to help in preventing heart health. Most can be safely taken in combination.
Since hyperlipidemia is a common risk factor for cardiovascular disease, adults with a new diagnoses of hyperlipidemia must have their levels kept under control to avoid the devastating outcomes that can arise from having uncontrolled hyperlipidemia. Nonpharmcologic lifestyle changes have been proven to be an effective first-line treatment for hyperlipidemia because of the changes that can be seen in one's total cholesterol, low density proteins, and high density proteins, but the problem arises on how much education is really being given to patients by their providers (Kelly, 2010). Providers in the outpatient setting are well aware of the recommendations in place on the amount of physical exercise that their patients should to be engaging in on a weekly basis, but the issue is how the information is being relayed to the patients.