Dysregulation Of Β-Cat Is The-naptic Morphogenesis Of ASD?

Associated with autism, there are a number of conditions comorbid to ASC. There is a high prevalence of epilepsy in individuals with autism, with a 1 in 4 prevalence, with seizures often starting in early childhood or adolescence. Tourette’s syndrome also has a higher prevalence within ASC then the neuro-typical population, with a prevalence of 6.5% compared to 2-3%. This may be due to abnormalities in dopamine, glutamate and serotonin abnormalities in autism. There is also a high proportion of individuals with learning difficulties, whether mild, moderate or severe, with a reporting from as low as 20% up to 70% prevalence.

Autism Spectrum Disorder is a growing problem throughout the entire globe. Autism Spectrum Disorder is defined as deficits in social reciprocity and communication, as well as unusual, restricted and repetitive behaviors (Lord). Such behaviors may include running back and forth, excessive cleaning, noises, and clapping. These also vary greatly with age and ability, and the notion of ASD has been introduced to recognize these diversities (Firth). Autism was first discovered in 1943 when Leo Kanner observed 11 children with several common traits such as, impairments in social interaction, anguish for changes, good memory, belated echolalia, over sensitivity to certain stimuli (especially sound), food problems, limitations in spontaneous activity,

Autism spectrum disorder (ASD) may be a disorder in the brain, caused by genetic, environmental or neural levels. Autism effects data processing in the brain by alerting how nerve cells and their synapses connect and organize; how this occurs not understand. (Johnson.2004)

For a number of children with autism having a companion dog is the difference between life and death. Methodically trained guide dogs help create an environment where autistic children are comfortable enough to live a more ordinary lifestyle. Autism spectrum disorder is a major public health problem that is the most common neurological disorder affecting 1 out of every 110 births in the US (Autism Society, 2009). ASDs can range in severity from Asperger Syndrome, a high-functioning form of autism where the child can function relatively well in society, to autistic disorder or classical ASD, which severely inhibits the child’s ability to socialize or communicate (NINDS). Autism manifests itself most strikingly as impairments in formation of

Autism is characterized as a neurodevelopmental disorder that affects social interactions, nonverbal and verbal communication, and restricted and repetitive behavior. On a global scale, autism was estimated to affect 21.7 million people in 2013, and the number continues to rise as time persists. Children are often diagnosed while they are infants, usually in the first two years of life, when parents notice odd behaviors such as assembling toys or stacking of objects. It is not yet well understood how autism occurs, but we do know that autism affects information processing in the brain by changing the way nerve cells and their synapses connect and organize. Autism is one of the three disorders that make up the Autism Spectrum, the second is

Park, H. R., Lee, J. M., Moon, H. E., Lee, D. S., Kim, B.-N., Kim, J., … Paek, S. H. (2016). A Short Review on the Current Understanding of Autism Spectrum Disorders. Experimental Neurobiology, 25(1), 1–13. http://doi.org/10.5607/en.2016.25.1.1

Chapter 1 focuses on autism, Pervasive Developmental Disorders (PDDs) and other Autistic Spectrum Disorders (ASDs). Described in 1943 by Dr. Leo Kanner, autism (also known as autistic disorder, childhood autism, or infantile disorder) is one of the PDDs along with Rett's disorder, Childhood Disintegrative Disorder (CDD) referred to as Heller's syndrome, Asperger disorder, and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). Rett's is a rare genetic abnormality affecting brain development in girls. There are treatments available, but there is no known cure. Asperger disorder affects an individual's ability to socialize and communicate effectively. Individuals with Asperger disorder may be socially awkward and have a compulsive

Szatmari P, Bartolucci G, Bremner R, Bond S, Rich S. A follow-up study of high-functioning autistic children. J Autism Dev Disord. 1989;19:213–25

Reduction in brain and neuronal sizes with an increase in cell density is consistently observed in several brain regions of patients with RTT (Calfa et al, 2015). These areas include the cerebral cortex, hypothalamus and the hippocampal formation (Belichenko et al, 2009). According to Belichenko (2009) dendritic morphology of neurons has been observed in a number of neurodevelopmental disorders, including RTT. An autoradiography done in the frontal cortex and basal ganglia of individuals affected by RTT have shown complex abnormalities in the density of glutamate receptors such as NMDA-(N-methyl-d-aspartate), AMPA-(α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainate- and metabotropic receptors (Blue et al, 1999).The prefrontal cortex of girls who were 2-8-year-old had increased NMDA receptors as compared to 10 year old girls who had reduced NMDA receptors. Receptor density was dependent on age of the patient (Blue et al, 1999). Changes in the neurons, such as decreased dendrites and decreased dendritic spine numbers are observed; particularly, changes in the hippocampal CA1 pyramidal neurons are shown (Chapeau et al, 2012). When compared to an age-matched control, researchers noticed that RTT affected patients had lower dendritic spine density in their

Neurological disorders are complex in nature and often the least understood. Given the recent boom in imaging technology and other diagnostic methods, it is now possible to see more clearly into the scope of neurological development and accurately determine the etiology of these diseases. One of such disorders is Autism; a multifactorial condition impairing normal brain development. It affects many aspects of development, including social behavior, cognitive ability and communication skills1 and is commonly diagnosed in children before the age of three1. The symptoms of this condition can vary greatly between individuals; hence its classification as a spectrum disorder. Asperger syndrome, Rett syndrome and pervasive

As research into autism spectrum disorders has increased over recent years and this has resulted in changes to the way that American psychiatry diagnoses autism spectrum disorders. The Diagnostic and Statistical Manual (DSM) is used by clinicians as a guide to diagnoses of mental health illnesses and since its first publication in 1930’s it has been updated every 20 years, and these updates reflect on new research and discoveries.

There are a lot of aspects to my personality that are worth noting. I am musically and dramatically inclined, and I consider myself to be a good writer. However, there is one that usurps them all. I have Asperger’s Syndrome. In one way, my diagnosis encapsulates my personality and my worldview.

and Mattson, 2011), and impairments of axonal transport and mitochondrial functions (Decker et al., 2010; Querfurth and LaFerla, 2010; Sheng and Cai, 2012). In addition, several lines of evidence suggest that Aβ regulates neuronal and synaptic activities and that its accumulation in the brain causes aberrant network activity and synaptic depression (Palop and Mucke, 2010). Impairments of inhibitory interneurons and aberrant stimulation of glutamate receptors result in excitotoxicity, and play important upstream roles in this pathogenic cascade. These impairments also lead to a positive feedback loop, where aberrant neuronal activity augments Aβ production, which in turn leads to further neuronal damage (Palop and Mucke, 2010; Bero et al., 2011; Verret et al.,

It has been known that PD is a disorder affecting the basal ganglia. The term basal ganglia is generally applied to a collection of nuclei situated deep within the cerebral hemispheres, lying laterally to the thalamus (Gazzeniga, George, and Mangun, 2008). The basal ganglia are important subcortical structures. They are composed of five nuclei: caudate, putamen, globus pallidus, subthalamic nucleus, and substantia nigra. These nuclei are not thought of a single anatomical entity; rather, they form a functional unity whose contribution is greatly to motor control. Interestingly, this system does not influence movement through spinal cord pathways, but rather acts as part of a feedback loop to all areas of the cerebral cortex, with primary input into motor areas (Aird, 2000). A number of excitatory and inhibitory neurotransmitters are what control this whole process, and a balance of both is required to ensure that smooth, purposeful movement takes place. In order to understand the pathways of which the basal ganglia take part in, it is essential to know the input and output connections of the basal ganglia. The input

The neurodevelopmental disorders, according to the DSM 5, are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning. Autism spectrum disorder (ASD) is newly classified as such; it was once classified as “Asperger’s Syndrome.” ASD is a severe neurodevelopmental impairment. The disorder limits the functioning capabilities of children and their capacity to communicate as well as interact with others. ASD effects how children perceive the world around them; socializing with others happens to be the most vital piece of development. Onset for ASD can occur as early as infancy, some children, however, may develop normal and then begin to suddenly withdraw and become unusually aggressive with those around them, they also begin to lose vocabulary and language skills they’ve once had. Other medical conditions may be comorbid with ASD; for example, epilepsy, intellectual and structural language disorders, mental disorders, sleep disorders, and avoidant-restrictive food intake disorders, (DSM 5, pg. 59).