E. Coli St131 Case Study

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E. coli ST131 is primarily an extraintestinal pathogenic E. coli (ExPEC) harbouring viru-lence genes required for successful pathogenic invasion of a human or animal host. These virulence genes allow the clone to do the following: to attach; to avoid and/or subvert host defense mechanisms within extraintestinal sites; to scavenge limiting nutri-ents, such as iron, from the host; and to incite a noxious host inflammatory response, cumulatively leading to extraintestinal diseases12. 2.1.2 Anti-O25b Antibodies At Arsanis humanized monoclonal antibodies (MAbs) were generated to target the lipo-polysaccharide O25b antigen conserved within this lineage. These MAbs bound to the surface of live bacterial cells irrespective of the capsular type expressed.
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