Edward Jenner: Cowpox Vaccine

The history of vaccinations begin with Edward Jenner, the country doctor from Gloucestershire who found, growing on cows, a nearly harmless virus the protected people from smallpox. Jenner’s vaccine was safer, more reliable, and more durable than variolation, and it is still the only vaccine to have eliminated its reason for being-in 1980, when the World Health Organization (WHO) declared the disease extinct. For nearly a century and a half, smallpox was the only vaccine routinely administered, and it saved millions of lives . But the controversy that marked the return of the vaccine, amid bioterrorism hysteria in 2002, was only the latest twist in the remarkable, mysterious life of vaccines.

Vaccines are one of the best inventions of our time. Vaccines’ abilities to fight infection and prevent deaths are incredible. According to the CDC, vaccination programs remain strong, with the US having the highest vaccination rate of 95 percent (CDC, 2004). However, despite the many benefits to not only the US, but also globally, these disease-fighting vaccines have caused many controversies over the years. This paper will help outline the history of vaccines and the anti-vaccine movement.

Today most children in the United States live a much healthier life and parents live with much less anxiety due to vaccinations. More than 200 years ago, Edward Jenner conducted an experiment that would be one of the most astounding breakthroughs in medical history. Jenner noticed that milkmaids didn’t catch the smallpox, a disease rampant across the English countryside. He reasoned that the blisters on the milkmaid’s hand must contain something that was protective. He tested his theory by taking fluid from a blister on the wrist of a milkmaid and inoculating it into the arm of a local laborer’s son (Offit and

Jenner. His experiments were extremely primal, however, and from that point on the vaccine production rate and quality rose exponentially. In 1809 the first United States law requiring vaccinations for smallpox was written after frequent outbreaks created great health and economic consequences.(Omer, 2011, 169-182). Before vaccines for children were created children died by the thousands from disease like in the 1920’s when diphtheria used to take on average 10,000 lives of children every year. The first vaccine as we have come to know them today emerged in 1914 with the first pertussis or whooping cough vaccine. This was followed by several Supreme Court decisions cementing a states right to create vaccination and school immunization laws regarding unvaccinated children and their ability to attend public and private schools. These decisions included the Jacobson v. Massachusetts decision of 1905 and a 1922 decision on a San Antonio, Texas case about a girl excluded from both public and private schools due to her lack of vaccination. Social call for change in the 1970’s called for the exclusion of unvaccinated children from schools to create quick improvement and controlled outbreak of a measles virus running rampant in the country. Thus after much legislative and social change on the subject of unvaccinated children’s exposure to

It was during this era that Edward Jenner invented a vaccine to prevent smallpox by inoculating a healthy eight-year old boy with cowpox;

However, Jenner’s invention became a common practice only a few years after he released it to the public, and according to The Hutchinson Unabridged Encyclopedia, “By 1890 smallpox had virtually been eradicated from Britain.” (“Jenner, Edward (1749-1823)”) From the information about the first vaccination, we can see that vaccinations have been proven to eliminate deadly diseases, whether they receive opposition or not. Without immunizations, we would be overcome with diseases, such as smallpox, polio, and measles.

Jenner’s vaccine was so successful that the World Health Organization declared the word “entirely eradicated” of human smallpox on December 9, 1979 (Spier, 2015). As a consequence of this monumental success and other successes like it, people forget how deadly diseases like this can be and fail to attribute their lack of a crippling disease to vaccinations. Other diseases that have been considered eliminated in a similar manner to smallpox are: diphtheria, tetanus, pertussis, polio, measles, mumps, rubella, hepatitis A & B, yellow fever (Spier, 2015).

Mandatory vaccination continues to be a contentious subject in the United States, even though extensive evidence proves inoculation prevents certain diseases. According to A. Plotkin & L. Plotkin (2011), the evolution of the first vaccine commenced in the 1700’s when a physician named Edwards Jenner discovered that cowpox protected individuals from one of the deadliest diseases termed smallpox. The precise virus Jenner used is unclear; however, it was espoused in the extermination of smallpox worldwide. The researchers further explained, the unearthing of the subsequent vaccine known as chicken cholera occurred approximately 80 years later by Louise Pasteur. Ever since, copious vaccines such as rabies, yellow fever, varicella, pneumococcal, mumps and recently HPV have been introduced.

Throughout history, smallpox has been one of the dreaded scourges that inflicted mankind. World Health Organization (WHO) stated that smallpox is responsible for the 300 million death cases worldwide in the twentieth century. (Fenner, Henderson, Arita, Jezek , & Ladnyi, 1988) (Plotkin, 2004) It was only after Dr Edward Jenner’s development on the principle of vaccination that provided the only accurate technique for the prevention of smallpox. The introduction of vaccinia vaccine enabled the global eradication of naturally occurring smallpox in 1970, it is recorded that the last known smallpox case recorded was in Somalia after the eradication. (Rappuoli, Miller, & Falkow, 2002) Jenner’s procedure has been a highly effective immunizing agent, however, it seemed that it isn’t a successful fighter to disease because it carries high incidence of adverse side effects and severe complications. (Madigan, Martinko, Stahl , & Clark, 2012)This

Vaccinations have been actively used for over 200 years now and have been effective for over 200 years as well. Western medicine’s introduction to the practice is said to have occurred within the eighteenth century, when a traveling British aristocrat, Lady Mary Wortley Montagu, reported her observations of Turkish children being injected with pus from smallpox victims. Although this practice seemed quite harsh, most of these children would contract only a mild version of the illness. In return, these recipients would retain a lifelong immunity to this terrible disease (World of Microbiology & Immunology). Similarly, in the United States, a Puritan minister by the name of Cotton Mather learned about inoculation from his African slave, Onesimus. Onesimus claimed that he was inoculated with smallpox pus and never caught the tragic disease (Williams). This type of medicinal treatment was initially rejected by most Western practitioners. They felt it was a dangerous and barbarous practice, but vaccination gained a tremendous amount of support at the turn of the nineteenth century when English physician Edward Jenner created a new smallpox vaccine derived from the relatively mild cowpox virus (Riedel). There’s no doubt that history has shown the positive outcomes of immunization and continued to show them as technology and medicine progressed.

Riedel, Stefan. "Edward Jenner and the History of Smallpox and Vaccination." Proceedings (Baylor University. Medical Center). Baylor Health Care System, Jan. 2005. Web. 12 Apr. 2017. . Edward Jenner developed a very strong interest in nature and science that continued throughout this entire life. Throughout this life, he worked underneath many surgeons and physicians. He introduced the vaccine for smallpox in 1796 when inoculated James Phipps, a young boy with cow pox virus.

Although most people think Edward Jenner was the first person to attempt a vaccination, this is not true. The earliest vaccinations started in the 7th century when snake venom was drank by Buddhists to try to gain immunity from snakebites. In 1796, Edward Jenner, a doctor in England, discovered he could give people immunity to smallpox by injecting them with material from cowpox lesions. Smallpox was a significant disease in most countries and killed millions of people in Europe and Mexico. Steps had already been taken to eradicate smallpox but it was Jenner who discovered using cowpox to immunize against smallpox as being the safest method. Using smallpox to create the vaccine was not safe so Jenner’s idea helped to save many people. This was the beginning of developing vaccines to keep people safe from diseases that were capable of wiping out entire populations. This

Until the development of the smallpox vaccine in 1796, inoculation using the live smallpox virus was the only way to protect people from the deadly disease. Those inoculated had a chance of contracting the full virus and potentially dying from the disease. When Edward Jenner discovered that he could use a similar disease found in cattle, he began the modern era of vaccination (The College of Physicians of Philadelphia, 2015). Over the next 200 years, smallpox was essentially driven extinct by vaccination programs. Due to vaccines, a disease that killed an estimated 300 million people in the 20th century alone now only exists in a Center for Disease Control laboratory. (Flight, 2011).

It was Edward Jenner’s challenges and work lead to what is now called the Smallpox Vaccine. However, it wasn’t until the 19th century that people started to accept the idea of vaccines and utilize them as a form of preventative treatment. Vaccines were vastly different from variolation in many ways. We were able to get all the benefits that were associated with variolation with out the side effects that were connected with them. Second hand diseases had the capability of being spread from person to person through variolation. This in turn produced a fear for second hand diseases that could arise from variolation. This problem was also found with vaccines, which, will be discussed later on. However, vaccinations didn’t mean we had lifelong immunity to the disease we still need to be revaccinated. Strands from the vaccine need to be shipped in order for other countries to use reap the positive benefits (Fenner ea. atl.,

According to my research, in 1796 Dr. Edward Jenner developed a vaccine for smallpox disease however during this time only cows were infected. This vaccine came from the cowpox virus. In 1809, the state of Massachusetts became the first to mandate the smallpox vaccinations then in 1879 a group of Anti-Vaccination of America was formed and their belief is that no one should be forced to vaccination. They believed that the vaccine was spreading the disease instead of preventing it. In 1986