Effective Gene Delivery And Its Effects On Hiv

987 Words4 Pages
There has been countless number of efforts to develop an effective gene transfer approach to treat HIV-1 infections globally. Many transgenes have been identified to inhibit in vitro HIV-1 infections. As drug resistant HIV-1 is increasingly common even with patients receiving HAART, designing drug treatment methods have been challenging. Therefore, investigation into new therapeutic approaches should continue. Gene delivery plays an important supporting role developing potential therapies directed towards HIV-1 infections. The goals of the anti-HIV-1 gene therapy are to deliver transgenes to directly susceptible cells, Immunize against HIV-1 antigens, inhibit HIV-1 proliferation in target organs, and deliver to Hematopoietic Progenitor Cells. Delivering transgenes to susceptible cells will make them resistant to HIV-1 infections and inhibit viral replication. When CCR5 a major coreceptor for HIV was disrupted in the “Berlin Patient” led to the revival of gene therapy. The naturally occurring CCR5-Δ32 mutation that results in a frameshift mutation dislocates the CCR5 expression on the cell surface. The “Berlin patient” who was HIV+ patient with lymphoma was transplanted with bone marrow from a donor with CCR5-Δ32 mutation and became ‘cured’ of HIV. But as only a small general population with CCR5-Δ32 mutation can be identified alternative methods must be identified for gene therapy. Though gene therapies for HIV-1 infections have been challenging recent work must be
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